U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Recurrent Adult Brain Neoplasm

MedGen UID:
75870
•Concept ID:
C0278786
•
Neoplastic Process
Synonyms: Recurrent Adult Brain Tumor; Recurrent Neoplasm of Adult Brain; Recurrent Neoplasm of the Adult Brain; Recurrent Tumor of Adult Brain; Recurrent Tumor of the Adult Brain; Relapsed Adult Brain Neoplasm; Relapsed Adult Brain Tumor; Relapsed Neoplasm of Adult Brain; Relapsed Neoplasm of the Adult Brain; Relapsed Tumor of Adult Brain; Relapsed Tumor of the Adult Brain

Definition

The reemergence of brain neoplasm in adulthood after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Adult Brain Neoplasm

Professional guidelines

PubMed

The Diagnosis and Treatment of Craniopharyngioma.
Müller HL
Neuroendocrinology 2020;110(9-10):753-766. Epub 2019 Nov 4 doi: 10.1159/000504512. PMID: 31678973
Glioblastoma: Overview of Disease and Treatment.
Davis ME
Clin J Oncol Nurs 2016 Oct 1;20(5 Suppl):S2-8. doi: 10.1188/16.CJON.S1.2-8. PMID: 27668386Free PMC Article
Treatment of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline.
Nieman LK, Biller BM, Findling JW, Murad MH, Newell-Price J, Savage MO, Tabarin A; Endocrine Society
J Clin Endocrinol Metab 2015 Aug;100(8):2807-31. Epub 2015 Jul 29 doi: 10.1210/jc.2015-1818. PMID: 26222757Free PMC Article

Recent clinical studies

Etiology

Benign Glioma.
Wu PB, Filley AC, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2. PMID: 37452934
Stereotactic Radiosurgery for Intracranial Primary Melanocytomas.
Dar N, Mantziaris G, Pikis S, Young L, Sheehan J
World Neurosurg 2022 Aug;164:160-166. Epub 2022 May 10 doi: 10.1016/j.wneu.2022.04.136. PMID: 35552031
Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial.
Mahajan A, Ahmed S, McAleer MF, Weinberg JS, Li J, Brown P, Settle S, Prabhu SS, Lang FF, Levine N, McGovern S, Sulman E, McCutcheon IE, Azeem S, Cahill D, Tatsui C, Heimberger AB, Ferguson S, Ghia A, Demonte F, Raza S, Guha-Thakurta N, Yang J, Sawaya R, Hess KR, Rao G
Lancet Oncol 2017 Aug;18(8):1040-1048. Epub 2017 Jul 4 doi: 10.1016/S1470-2045(17)30414-X. PMID: 28687375Free PMC Article
Glioblastoma: Overview of Disease and Treatment.
Davis ME
Clin J Oncol Nurs 2016 Oct 1;20(5 Suppl):S2-8. doi: 10.1188/16.CJON.S1.2-8. PMID: 27668386Free PMC Article
Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05.
Shaw E, Scott C, Souhami L, Dinapoli R, Kline R, Loeffler J, Farnan N
Int J Radiat Oncol Biol Phys 2000 May 1;47(2):291-8. doi: 10.1016/s0360-3016(99)00507-6. PMID: 10802351

Diagnosis

Benign Glioma.
Wu PB, Filley AC, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2. PMID: 37452934
Structure and evolution of double minutes in diagnosis and relapse brain tumors.
Xu K, Ding L, Chang TC, Shao Y, Chiang J, Mulder H, Wang S, Shaw TI, Wen J, Hover L, McLeod C, Wang YD, Easton J, Rusch M, Dalton J, Downing JR, Ellison DW, Zhang J, Baker SJ, Wu G
Acta Neuropathol 2019 Jan;137(1):123-137. Epub 2018 Sep 28 doi: 10.1007/s00401-018-1912-1. PMID: 30267146Free PMC Article
Stereotactic Radiosurgery and Hypofractionated Radiotherapy for Glioblastoma.
Shah JL, Li G, Shaffer JL, Azoulay MI, Gibbs IC, Nagpal S, Soltys SG
Neurosurgery 2018 Jan 1;82(1):24-34. doi: 10.1093/neuros/nyx115. PMID: 28605463
Glioblastoma: Overview of Disease and Treatment.
Davis ME
Clin J Oncol Nurs 2016 Oct 1;20(5 Suppl):S2-8. doi: 10.1188/16.CJON.S1.2-8. PMID: 27668386Free PMC Article
Cerebellar aspergilloma.
Björkholm B, Elgefors B
Scand J Infect Dis 1986;18(4):375-8. doi: 10.3109/00365548609032350. PMID: 3764353

Therapy

Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma: The CheckMate 143 Phase 3 Randomized Clinical Trial.
Reardon DA, Brandes AA, Omuro A, Mulholland P, Lim M, Wick A, Baehring J, Ahluwalia MS, Roth P, Bähr O, Phuphanich S, Sepulveda JM, De Souza P, Sahebjam S, Carleton M, Tatsuoka K, Taitt C, Zwirtes R, Sampson J, Weller M
JAMA Oncol 2020 Jul 1;6(7):1003-1010. doi: 10.1001/jamaoncol.2020.1024. PMID: 32437507Free PMC Article
Stereotactic Radiosurgery and Hypofractionated Radiotherapy for Glioblastoma.
Shah JL, Li G, Shaffer JL, Azoulay MI, Gibbs IC, Nagpal S, Soltys SG
Neurosurgery 2018 Jan 1;82(1):24-34. doi: 10.1093/neuros/nyx115. PMID: 28605463
Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC·3): a multicentre, randomised, controlled, phase 3 trial.
Brown PD, Ballman KV, Cerhan JH, Anderson SK, Carrero XW, Whitton AC, Greenspoon J, Parney IF, Laack NNI, Ashman JB, Bahary JP, Hadjipanayis CG, Urbanic JJ, Barker FG 2nd, Farace E, Khuntia D, Giannini C, Buckner JC, Galanis E, Roberge D
Lancet Oncol 2017 Aug;18(8):1049-1060. Epub 2017 Jul 4 doi: 10.1016/S1470-2045(17)30441-2. PMID: 28687377Free PMC Article
Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial.
Mahajan A, Ahmed S, McAleer MF, Weinberg JS, Li J, Brown P, Settle S, Prabhu SS, Lang FF, Levine N, McGovern S, Sulman E, McCutcheon IE, Azeem S, Cahill D, Tatsui C, Heimberger AB, Ferguson S, Ghia A, Demonte F, Raza S, Guha-Thakurta N, Yang J, Sawaya R, Hess KR, Rao G
Lancet Oncol 2017 Aug;18(8):1040-1048. Epub 2017 Jul 4 doi: 10.1016/S1470-2045(17)30414-X. PMID: 28687375Free PMC Article
Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05.
Shaw E, Scott C, Souhami L, Dinapoli R, Kline R, Loeffler J, Farnan N
Int J Radiat Oncol Biol Phys 2000 May 1;47(2):291-8. doi: 10.1016/s0360-3016(99)00507-6. PMID: 10802351

Prognosis

Stereotactic Radiosurgery for Intracranial Primary Melanocytomas.
Dar N, Mantziaris G, Pikis S, Young L, Sheehan J
World Neurosurg 2022 Aug;164:160-166. Epub 2022 May 10 doi: 10.1016/j.wneu.2022.04.136. PMID: 35552031
Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC·3): a multicentre, randomised, controlled, phase 3 trial.
Brown PD, Ballman KV, Cerhan JH, Anderson SK, Carrero XW, Whitton AC, Greenspoon J, Parney IF, Laack NNI, Ashman JB, Bahary JP, Hadjipanayis CG, Urbanic JJ, Barker FG 2nd, Farace E, Khuntia D, Giannini C, Buckner JC, Galanis E, Roberge D
Lancet Oncol 2017 Aug;18(8):1049-1060. Epub 2017 Jul 4 doi: 10.1016/S1470-2045(17)30441-2. PMID: 28687377Free PMC Article
Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial.
Mahajan A, Ahmed S, McAleer MF, Weinberg JS, Li J, Brown P, Settle S, Prabhu SS, Lang FF, Levine N, McGovern S, Sulman E, McCutcheon IE, Azeem S, Cahill D, Tatsui C, Heimberger AB, Ferguson S, Ghia A, Demonte F, Raza S, Guha-Thakurta N, Yang J, Sawaya R, Hess KR, Rao G
Lancet Oncol 2017 Aug;18(8):1040-1048. Epub 2017 Jul 4 doi: 10.1016/S1470-2045(17)30414-X. PMID: 28687375Free PMC Article
Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05.
Shaw E, Scott C, Souhami L, Dinapoli R, Kline R, Loeffler J, Farnan N
Int J Radiat Oncol Biol Phys 2000 May 1;47(2):291-8. doi: 10.1016/s0360-3016(99)00507-6. PMID: 10802351
Pineal tumors.
Bruce JN, Stein BM
Neurosurg Clin N Am 1990 Jan;1(1):123-38. PMID: 2135964

Clinical prediction guides

RADIOSURGICAL TREATMENT OF RECURRENT GLIOBLASTOMA AND PROGNOSTIC FACTORS AFFECTING TREATMENT OUTCOMES.
Glavatskyi OY, Griazov AB, Chuvashova OY, Kruchok IV, Griazov AA, Khmelnytskyi HV, Shuba IM, Stuley VA, Zemskova OV
Exp Oncol 2022 Dec;44(4):307-313. doi: 10.32471/exp-oncology.2312-8852.vol-44-no-4.18920. PMID: 36811543
Clinical characteristics and prognostic factors of adult patients with pilocytic astrocytoma.
Mair MJ, Wöhrer A, Furtner J, Simonovska A, Kiesel B, Oberndorfer S, Ungersböck K, Marosi C, Sahm F, Hainfellner JA, Rössler K, Preusser M, Widhalm G, Berghoff AS
J Neurooncol 2020 May;148(1):187-198. Epub 2020 Apr 27 doi: 10.1007/s11060-020-03513-9. PMID: 32342331Free PMC Article
Cerebral Radiation Necrosis: An Analysis of Clinical and Quantitative Imaging and Volumetric Features.
Feng R, Loewenstern J, Aggarwal A, Pawha P, Gilani A, Iloreta AM, Bakst R, Miles B, Bederson J, Costa A, Gupta V, Shrivastava RK
World Neurosurg 2018 Mar;111:e485-e494. Epub 2017 Dec 26 doi: 10.1016/j.wneu.2017.12.104. PMID: 29288110
Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial.
Mahajan A, Ahmed S, McAleer MF, Weinberg JS, Li J, Brown P, Settle S, Prabhu SS, Lang FF, Levine N, McGovern S, Sulman E, McCutcheon IE, Azeem S, Cahill D, Tatsui C, Heimberger AB, Ferguson S, Ghia A, Demonte F, Raza S, Guha-Thakurta N, Yang J, Sawaya R, Hess KR, Rao G
Lancet Oncol 2017 Aug;18(8):1040-1048. Epub 2017 Jul 4 doi: 10.1016/S1470-2045(17)30414-X. PMID: 28687375Free PMC Article
Comprehensive portrait of recurrent glioblastoma multiforme in molecular and clinical characteristics.
Li R, Chen X, You Y, Wang X, Liu Y, Hu Q, Yan W
Oncotarget 2015 Oct 13;6(31):30968-74. doi: 10.18632/oncotarget.5038. PMID: 26427041Free PMC Article

Recent systematic reviews

Characteristics and Outcomes in Pediatric Versus Adult Craniopharyngiomas: A Systematic Review and Meta-Analysis.
Pang JC, Chung DD, Wang J, Abiri A, Lien BV, Himstead AS, Ovakimyan A, Kim MG, Hsu FPK, Kuan EC
Neurosurgery 2023 Jun 1;92(6):1112-1129. Epub 2023 Jan 13 doi: 10.1227/neu.0000000000002346. PMID: 36639856
Brain magnetic resonance spectroscopy to differentiate recurrent neoplasm from radiation necrosis: A systematic review and meta-analysis.
Aseel A, McCarthy P, Mohammed A
J Neuroimaging 2023 Mar;33(2):189-201. Epub 2023 Jan 11 doi: 10.1111/jon.13080. PMID: 36631883
Stereotactic Radiosurgery for Intracranial Primary Melanocytomas.
Dar N, Mantziaris G, Pikis S, Young L, Sheehan J
World Neurosurg 2022 Aug;164:160-166. Epub 2022 May 10 doi: 10.1016/j.wneu.2022.04.136. PMID: 35552031
Deep vein thrombosis and brain metastases. Case report and systematic review.
Lopez-Ruz S, Barca-Hernando M, Jara-Palomares L
Thromb Res 2021 Jan;197:195-201. Epub 2020 Nov 10 doi: 10.1016/j.thromres.2020.11.005. PMID: 33232836
Management of recurrent medulloblastoma in adult patients: a systematic review and recommendations.
Kostaras X, Easaw JC
J Neurooncol 2013 Oct;115(1):1-8. Epub 2013 Jul 23 doi: 10.1007/s11060-013-1206-3. PMID: 23877361

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...