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Usual ductal breast hyperplasia

MedGen UID:
759542
•Concept ID:
C3532429
•
Neoplastic Process
Synonyms: Breast Hyperplasia without Atypia; Breast Usual Ductal Hyperplasia; Ductal Breast Hyperplasia of Usual Type; ductal breast hyperplasia of usual type; Ordinary Intraductal Breast Hyperplasia; ordinary intraductal breast hyperplasia; UDH; Usual Ductal Breast Hyperplasia; usual ductal breast hyperplasia; Usual ductal hyperplasia of breast; Usual hyperplasia of lactiferous duct
SNOMED CT: Usual hyperplasia of lactiferous duct (472905007); Usual ductal hyperplasia of breast (472905007)
 
Monarch Initiative: MONDO:0006484

Definition

A neoplastic ductal proliferative lesion of the breast characterized by the formation of secondary lumens and prominent intraductal proliferation of a heterogeneous cellular population that may include epithelial cells, myoepithelial cells, or metaplastic apocrine cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUsual ductal breast hyperplasia

Professional guidelines

PubMed

The role of immunohistochemistry in the differential diagnosis of papillary lesions of the breast.
Tse GM, Tan PH, Moriya T
J Clin Pathol 2009 May;62(5):407-13. Epub 2009 Jan 6 doi: 10.1136/jcp.2008.063016. PMID: 19126567
New trends of immunohistochemistry for making differential diagnosis of breast lesions.
Moriya T, Kasajima A, Ishida K, Kariya Y, Akahira J, Endoh M, Watanabe M, Sasano H
Med Mol Morphol 2006 Mar;39(1):8-13. doi: 10.1007/s00795-006-0309-8. PMID: 16575508
The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions.
Reis-Filho JS, Lakhani SR
Breast Cancer Res 2003;5(6):313-9. Epub 2003 Oct 9 doi: 10.1186/bcr650. PMID: 14580249Free PMC Article

Recent clinical studies

Etiology

Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
14-3-3ζ promoted invasion and lymph node metastasis of breast invasive ductal carcinoma with HER2 overexpression.
Wan D, Zhang Y, Yu Q, Li F, Zhuo J
Pathol Res Pract 2021 Nov;227:153619. Epub 2021 Sep 22 doi: 10.1016/j.prp.2021.153619. PMID: 34560418
Association between mammographic breast density and histologic features of benign breast disease.
Ghosh K, Vierkant RA, Frank RD, Winham S, Visscher DW, Pankratz VS, Scott CG, Brandt K, Sherman ME, Radisky DC, Frost MH, Hartmann LC, Degnim AC, Vachon CM
Breast Cancer Res 2017 Dec 19;19(1):134. doi: 10.1186/s13058-017-0922-6. PMID: 29258587Free PMC Article
Molecular evolution of breast cancer.
Simpson PT, Reis-Filho JS, Gale T, Lakhani SR
J Pathol 2005 Jan;205(2):248-54. doi: 10.1002/path.1691. PMID: 15641021
Pathology of high-risk breast lesions and ductal carcinoma in situ.
Sewell CW
Radiol Clin North Am 2004 Sep;42(5):821-30, v. doi: 10.1016/j.rcl.2004.03.013. PMID: 15337418

Diagnosis

Usual breast lump with unusual features.
Gupta S, Kumar P, Kumari N, Srivastava NK
Cytopathology 2024 Mar;35(2):310-312. Epub 2023 Oct 24 doi: 10.1111/cyt.13316. PMID: 37874012
The Utility of SOX10 Immunohistochemical Staining in Breast Pathology.
Rammal R, Goel K, Elishaev E, Rinda Soong T, Jones MW, Zhao C, Clark BZ, Carter GJ, Yu J, Fine JL, Villatoro TM, Harinath L, Bhargava R
Am J Clin Pathol 2022 Nov 3;158(5):616-625. doi: 10.1093/ajcp/aqac092. PMID: 36000970
Atypia in breast pathology: what pathologists need to know.
Katayama A, Toss MS, Parkin M, Ellis IO, Quinn C, Rakha EA
Pathology 2022 Feb;54(1):20-31. Epub 2021 Dec 3 doi: 10.1016/j.pathol.2021.09.008. PMID: 34872753
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Use of immunohistochemistry in the diagnosis of problematic breast lesions.
Lee AH
J Clin Pathol 2013 Jun;66(6):471-7. Epub 2013 Mar 13 doi: 10.1136/jclinpath-2012-201109. PMID: 23486609

Therapy

Reduced RKIP Expression is Associated With Breast Neoplastic Progression and is Correlated With Poor Outcomes and Aberrant Methylation in Breast Carcinoma.
Kim GE, Kim NI, Lee JS, Park MH, Yoon JH
Appl Immunohistochem Mol Morphol 2017 Aug;25(7):467-474. doi: 10.1097/PAI.0000000000000323. PMID: 26894644
S-(-)equol producing status not associated with breast cancer risk among low isoflavone-consuming US postmenopausal women undergoing a physician-recommended breast biopsy.
Virk-Baker MK, Barnes S, Krontiras H, Nagy TR
Nutr Res 2014 Feb;34(2):116-25. Epub 2013 Dec 18 doi: 10.1016/j.nutres.2013.12.002. PMID: 24461312Free PMC Article
Comparison of immunohistochemical staining in breast papillary neoplasms of cytokeratin 5/6 and p63 in core needle biopsies and surgical excisions.
Koo JS, Kim MJ, Kim EK, Park BW
Appl Immunohistochem Mol Morphol 2012 Mar;20(2):108-15. doi: 10.1097/pai.0b013e318235a917. PMID: 22553810
Epstein-Barr virus and breast cancer: lack of evidence for an association in Iranian women.
Kadivar M, Monabati A, Joulaee A, Hosseini N
Pathol Oncol Res 2011 Sep;17(3):489-92. Epub 2011 Jan 6 doi: 10.1007/s12253-010-9325-z. PMID: 21207256
Monoclonality in normal epithelium and in hyperplastic and neoplastic lesions of the breast.
Diallo R, Schaefer KL, Poremba C, Shivazi N, Willmann V, Buerger H, Dockhorn-Dworniczak B, Boecker W
J Pathol 2001 Jan;193(1):27-32. doi: 10.1002/1096-9896(2000)9999:9999<::AID-PATH747>3.0.CO;2-H. PMID: 11169512

Prognosis

Adenomyoepithelioma of the Breast: A Report of 3 Cases.
AlQurashi M, Abdel Hadi M, Binammar AA, Al Muhanna A, Kussaibi H, Al Shammary E
Am J Case Rep 2022 Apr 11;23:e936070. doi: 10.12659/AJCR.936070. PMID: 35400730Free PMC Article
14-3-3ζ promoted invasion and lymph node metastasis of breast invasive ductal carcinoma with HER2 overexpression.
Wan D, Zhang Y, Yu Q, Li F, Zhuo J
Pathol Res Pract 2021 Nov;227:153619. Epub 2021 Sep 22 doi: 10.1016/j.prp.2021.153619. PMID: 34560418
CD133 expressionand clinicopathologic significance in benign and malignant breast lesions.
Liu TT, Li XF, Wang L, Yang JL
Cancer Biomark 2020;28(3):293-299. doi: 10.3233/CBM-190196. PMID: 32390595
Decreased Nek9 expression correlates with aggressive behaviour and predicts unfavourable prognosis in breast cancer.
Xu Z, Shen W, Pan A, Sun F, Zhang J, Gao P, Li L
Pathology 2020 Apr;52(3):329-335. Epub 2020 Feb 22 doi: 10.1016/j.pathol.2019.11.008. PMID: 32098687
Anatomic indicators (histologic and cytologic) of increased breast cancer risk.
Page DL, Dupont WD
Breast Cancer Res Treat 1993 Nov;28(2):157-66. doi: 10.1007/BF00666428. PMID: 8173068

Clinical prediction guides

Adenomyoepithelioma of the Breast: A Report of 3 Cases.
AlQurashi M, Abdel Hadi M, Binammar AA, Al Muhanna A, Kussaibi H, Al Shammary E
Am J Case Rep 2022 Apr 11;23:e936070. doi: 10.12659/AJCR.936070. PMID: 35400730Free PMC Article
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Nuclear morphology in breast lesions: refining its assessment to improve diagnostic concordance.
Katayama A, Toss MS, Parkin M, Sano T, Oyama T, Quinn CM, Ellis IO, Rakha EA
Histopathology 2022 Feb;80(3):515-528. Epub 2021 Dec 2 doi: 10.1111/his.14577. PMID: 34605058
14-3-3ζ promoted invasion and lymph node metastasis of breast invasive ductal carcinoma with HER2 overexpression.
Wan D, Zhang Y, Yu Q, Li F, Zhuo J
Pathol Res Pract 2021 Nov;227:153619. Epub 2021 Sep 22 doi: 10.1016/j.prp.2021.153619. PMID: 34560418
Atypical ductal hyperplasia: interobserver and intraobserver variability.
Jain RK, Mehta R, Dimitrov R, Larsson LG, Musto PM, Hodges KB, Ulbright TM, Hattab EM, Agaram N, Idrees MT, Badve S
Mod Pathol 2011 Jul;24(7):917-23. Epub 2011 Apr 29 doi: 10.1038/modpathol.2011.66. PMID: 21532546

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