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Breast Ductal Hyperplasia

MedGen UID:
152858
•Concept ID:
C0741698
•
Finding
Synonyms: Breast Epithelial Hyperplasia; Ductal Breast Hyperplasia; Ductal Hyperplasia of Breast; Ductal Hyperplasia of the Breast; Epithelial Hyperplasia of Breast; Epithelial Hyperplasia of the Breast

Definition

Hyperplasia of the epithelial cells in the breast ducts. It includes the atypical ductal hyperplasia, papillary intraductal hyperplasia, intraductal myoepitheliosis, and ductal hyperplasia of the usual type. [from NCI]

Professional guidelines

PubMed

European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.
Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Ductal carcinoma in situ: treatment or active surveillance?
Kuerer HM
Expert Rev Anticancer Ther 2015;15(7):777-85. Epub 2015 May 4 doi: 10.1586/14737140.2015.1043897. PMID: 25938920

Recent clinical studies

Etiology

Expression and significance of SATB1 in the development of breast cancer.
Zhang S, Gao X, Ma Y, Jiang J, Dai Z, Yin X, Min W, Hui W, Wang B
Genet Mol Res 2015 Apr 13;14(2):3309-17. doi: 10.4238/2015.April.13.10. PMID: 25966097
p53 nuclear accumulation and ERalpha expression in ductal hyperplasia of breast in a cohort of 215 Chinese women.
Mao XY, Fan CF, Zheng HC, Wei J, Yao F, Jin F
J Exp Clin Cancer Res 2010 Aug 16;29(1):112. doi: 10.1186/1756-9966-29-112. PMID: 20712900Free PMC Article

Prognosis

Expression and significance of SATB1 in the development of breast cancer.
Zhang S, Gao X, Ma Y, Jiang J, Dai Z, Yin X, Min W, Hui W, Wang B
Genet Mol Res 2015 Apr 13;14(2):3309-17. doi: 10.4238/2015.April.13.10. PMID: 25966097
Low-grade salivary duct carcinoma: description of 16 cases.
Brandwein-Gensler M, Hille J, Wang BY, Urken M, Gordon R, Wang LJ, Simpson JR, Simpson RH, Gnepp DR
Am J Surg Pathol 2004 Aug;28(8):1040-4. doi: 10.1097/01.pas.0000128662.66321.be. PMID: 15252310

Clinical prediction guides

p53 nuclear accumulation and ERalpha expression in ductal hyperplasia of breast in a cohort of 215 Chinese women.
Mao XY, Fan CF, Zheng HC, Wei J, Yao F, Jin F
J Exp Clin Cancer Res 2010 Aug 16;29(1):112. doi: 10.1186/1756-9966-29-112. PMID: 20712900Free PMC Article
CD34+ fibrocytes in invasive ductal carcinoma, ductal carcinoma in situ, and benign breast lesions.
Barth PJ, Ebrahimsade S, Ramaswamy A, Moll R
Virchows Arch 2002 Mar;440(3):298-303. Epub 2001 Nov 22 doi: 10.1007/s004280100530. PMID: 11889601

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