U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Neonatal Neutropenia

MedGen UID:
810611
•Concept ID:
C0543693
•
Disease or Syndrome

Definition

A condition characterized by a decrease in the number of neutrophils in the blood below established reference ranges in a newborn. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal Neutropenia

Professional guidelines

PubMed

Neonatal neutropenia: what diagnostic evaluation is needed and when is treatment recommended?
Del Vecchio A, Christensen RD
Early Hum Dev 2012 May;88 Suppl 2:S19-24. doi: 10.1016/S0378-3782(12)70007-5. PMID: 22633505
Current treatment options to prevent perinatal transmission of herpes simplex virus.
Leung DT, Sacks SL
Expert Opin Pharmacother 2003 Oct;4(10):1809-19. doi: 10.1517/14656566.4.10.1809. PMID: 14521490
Recent advances in the pathogenesis and treatment of nonimmune neutropenias in the neonate.
Calhoun DA, Christensen RD
Curr Opin Hematol 1998 Jan;5(1):37-41. doi: 10.1097/00062752-199801000-00007. PMID: 9515201

Recent clinical studies

Etiology

Maternal Hypertension and Early-Onset Neonatal Neutropenia.
Joslyn P, Oral E, Martin A, Surcouf J, Barkemeyer B
Fetal Pediatr Pathol 2023 Oct;42(5):735-745. Epub 2023 Jun 5 doi: 10.1080/15513815.2023.2220406. PMID: 37272337
Incidence of Neonatal Neutropenia and Leukopenia After In Utero Exposure to Chemotherapy for Maternal Cancer.
La Nasa M, Gaughan J, Cardonick E
Am J Clin Oncol 2019 Apr;42(4):351-354. doi: 10.1097/COC.0000000000000527. PMID: 30789413
How I manage children with neutropenia.
Dale DC
Br J Haematol 2017 Aug;178(3):351-363. Epub 2017 Apr 17 doi: 10.1111/bjh.14677. PMID: 28419427
Immune neutropenias of infancy and childhood.
Farruggia P
World J Pediatr 2016 May;12(2):142-8. Epub 2015 Nov 19 doi: 10.1007/s12519-015-0056-9. PMID: 26582295
Immune-mediated neutropenia in the neonate.
Maheshwari A, Christensen RD, Calhoun DA
Acta Paediatr Suppl 2002;91(438):98-103. doi: 10.1111/j.1651-2227.2002.tb02912.x. PMID: 12477271

Diagnosis

How I manage children with neutropenia.
Dale DC
Br J Haematol 2017 Aug;178(3):351-363. Epub 2017 Apr 17 doi: 10.1111/bjh.14677. PMID: 28419427
Neutropenia in the newborn.
Maheshwari A
Curr Opin Hematol 2014 Jan;21(1):43-9. doi: 10.1097/MOH.0000000000000010. PMID: 24322487Free PMC Article
Neonatal neutropenia: what diagnostic evaluation is needed and when is treatment recommended?
Del Vecchio A, Christensen RD
Early Hum Dev 2012 May;88 Suppl 2:S19-24. doi: 10.1016/S0378-3782(12)70007-5. PMID: 22633505
Immune neutropenia in the neonate.
Maheshwari A, Christensen RD, Calhoun DA
Adv Pediatr 2002;49:317-39. PMID: 12214777
Isoimmune neonatal neutropenia.
Levine DH, Madyastha PR
Am J Perinatol 1986 Jul;3(3):231-3. doi: 10.1055/s-2007-999873. PMID: 3718645

Therapy

Incidence of Neonatal Neutropenia and Leukopenia After In Utero Exposure to Chemotherapy for Maternal Cancer.
La Nasa M, Gaughan J, Cardonick E
Am J Clin Oncol 2019 Apr;42(4):351-354. doi: 10.1097/COC.0000000000000527. PMID: 30789413
How I manage children with neutropenia.
Dale DC
Br J Haematol 2017 Aug;178(3):351-363. Epub 2017 Apr 17 doi: 10.1111/bjh.14677. PMID: 28419427
Neutropenia in the newborn.
Maheshwari A
Curr Opin Hematol 2014 Jan;21(1):43-9. doi: 10.1097/MOH.0000000000000010. PMID: 24322487Free PMC Article
Neonatal neutropenia: what diagnostic evaluation is needed and when is treatment recommended?
Del Vecchio A, Christensen RD
Early Hum Dev 2012 May;88 Suppl 2:S19-24. doi: 10.1016/S0378-3782(12)70007-5. PMID: 22633505
Immune-mediated neutropenia in the neonate.
Maheshwari A, Christensen RD, Calhoun DA
Acta Paediatr Suppl 2002;91(438):98-103. doi: 10.1111/j.1651-2227.2002.tb02912.x. PMID: 12477271

Prognosis

Severe Transitory Neonatal Neutropenia Associated with Maternal Autoimmune or Idiopathic Neutropenia.
Seguier J, Barlogis V, Croisille L, Audrain M, Ebbo M, Beaupain B, Meunier B, Vallentin B, Jean R, Harle JR, Donadieu J, Schleinitz N
J Clin Immunol 2019 Feb;39(2):200-206. Epub 2019 Mar 21 doi: 10.1007/s10875-019-00608-5. PMID: 30900095
Incidence of Neonatal Neutropenia and Leukopenia After In Utero Exposure to Chemotherapy for Maternal Cancer.
La Nasa M, Gaughan J, Cardonick E
Am J Clin Oncol 2019 Apr;42(4):351-354. doi: 10.1097/COC.0000000000000527. PMID: 30789413
Immune neutropenias of infancy and childhood.
Farruggia P
World J Pediatr 2016 May;12(2):142-8. Epub 2015 Nov 19 doi: 10.1007/s12519-015-0056-9. PMID: 26582295
Neutropenia in the newborn.
Maheshwari A
Curr Opin Hematol 2014 Jan;21(1):43-9. doi: 10.1097/MOH.0000000000000010. PMID: 24322487Free PMC Article
Immune-mediated neutropenia in the neonate.
Maheshwari A, Christensen RD, Calhoun DA
Acta Paediatr Suppl 2002;91(438):98-103. doi: 10.1111/j.1651-2227.2002.tb02912.x. PMID: 12477271

Clinical prediction guides

Severe Transitory Neonatal Neutropenia Associated with Maternal Autoimmune or Idiopathic Neutropenia.
Seguier J, Barlogis V, Croisille L, Audrain M, Ebbo M, Beaupain B, Meunier B, Vallentin B, Jean R, Harle JR, Donadieu J, Schleinitz N
J Clin Immunol 2019 Feb;39(2):200-206. Epub 2019 Mar 21 doi: 10.1007/s10875-019-00608-5. PMID: 30900095
How I manage children with neutropenia.
Dale DC
Br J Haematol 2017 Aug;178(3):351-363. Epub 2017 Apr 17 doi: 10.1111/bjh.14677. PMID: 28419427
Number of sites of perinatal Candida colonization and neutropenia are associated with nosocomial candidemia in the neonatal intensive care unit patient.
Mahieu LM, Van Gasse N, Wildemeersch D, Jansens H, Ieven M
Pediatr Crit Care Med 2010 Mar;11(2):240-5. doi: 10.1097/PCC.0b013e3181b808fb. PMID: 19794324
Granulocyte antigen systems and antibodies and their clinical significance.
McCullough J
Hum Pathol 1983 Mar;14(3):228-34. doi: 10.1016/s0046-8177(83)80022-7. PMID: 6832770
Neutrophil antigens: immunology and clinical implications.
Lalezari P
Prog Clin Biol Res 1977;13:209-25. PMID: 400755

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...