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Salivary gland large cell carcinoma

MedGen UID:
810975
•Concept ID:
C2111671
•
Neoplastic Process
Synonyms: Large Cell Salivary Gland Carcinoma; large cell salivary gland carcinoma; Large Cell Undifferentiated Salivary Gland Carcinoma; large cell undifferentiated salivary gland carcinoma; saliva-secreting gland large cell carcinoma; Salivary Gland Large Cell Carcinoma; salivary gland large cell carcinoma
 
Monarch Initiative: MONDO:0006404

Definition

A rare, highly aggressive carcinoma that arises from the salivary gland, predominantly the parotid gland. It is characterized by the presence of large pleomorphic malignant cells with or without neuroendocrine differentiation. Patients usually present with a rapidly growing mass. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary gland large cell carcinoma

Professional guidelines

PubMed

Current diagnosis and treatment of salivary gland-type tumors of the lung.
Horio Y, Kuroda H, Masago K, Matsushita H, Sasaki E, Fujiwara Y
Jpn J Clin Oncol 2024 Mar 9;54(3):229-247. doi: 10.1093/jjco/hyad160. PMID: 38018262
Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article
Long-term treatment outcome of minor salivary gland carcinoma of the hard palate.
Li Q, Zhang XR, Liu XK, Liu ZM, Liu WW, Li H, Guo ZM
Oral Oncol 2012 May;48(5):456-62. Epub 2012 Jan 16 doi: 10.1016/j.oraloncology.2011.12.005. PMID: 22248739

Recent clinical studies

Etiology

Salivary Gland Secretory Carcinoma: Clinicopathologic and Genetic Characteristics of 215 Cases and Proposal for a Grading System.
Baněčková M, Thompson LDR, Hyrcza MD, Vaněček T, Agaimy A, Laco J, Simpson RHW, Di Palma S, Stevens TM, Brcic L, Etebarian A, Dimnik K, Majewska H, Stárek I, O'Regan E, Salviato T, Helliwell T, Horáková M, Biernat W, Onyuma T, Michal M, Leivo I, Skalova A
Am J Surg Pathol 2023 Jun 1;47(6):661-677. Epub 2023 Apr 18 doi: 10.1097/PAS.0000000000002043. PMID: 37070739
Sinonasal Acinic Cell Carcinoma: A Review of the National Cancer Database.
Kshirsagar RS, Eide JG, Brant JA, Palmer JN, Adappa ND
Am J Rhinol Allergy 2022 Nov;36(6):741-746. Epub 2022 Jun 14 doi: 10.1177/19458924221107206. PMID: 35702005
Large cell neuroendocrine carcinoma of the submandibular gland: a case report and literature review.
Mascitti M, Luconi E, Togni L, Rubini C
Pathologica 2019 Jun;111(2):70-75. doi: 10.32074/1591-951X-13-19. PMID: 31388199
Newly Described Entities in Salivary Gland Pathology.
Skálová A, Gnepp DR, Lewis JS Jr, Hunt JL, Bishop JA, Hellquist H, Rinaldo A, Vander Poorten V, Ferlito A
Am J Surg Pathol 2017 Aug;41(8):e33-e47. doi: 10.1097/PAS.0000000000000883. PMID: 28614209
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

Diagnosis

Current diagnosis and treatment of salivary gland-type tumors of the lung.
Horio Y, Kuroda H, Masago K, Matsushita H, Sasaki E, Fujiwara Y
Jpn J Clin Oncol 2024 Mar 9;54(3):229-247. doi: 10.1093/jjco/hyad160. PMID: 38018262
Salivary Gland Secretory Carcinoma: Clinicopathologic and Genetic Characteristics of 215 Cases and Proposal for a Grading System.
Baněčková M, Thompson LDR, Hyrcza MD, Vaněček T, Agaimy A, Laco J, Simpson RHW, Di Palma S, Stevens TM, Brcic L, Etebarian A, Dimnik K, Majewska H, Stárek I, O'Regan E, Salviato T, Helliwell T, Horáková M, Biernat W, Onyuma T, Michal M, Leivo I, Skalova A
Am J Surg Pathol 2023 Jun 1;47(6):661-677. Epub 2023 Apr 18 doi: 10.1097/PAS.0000000000002043. PMID: 37070739
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Overview of the 2022 WHO Classification of Head and Neck Neuroendocrine Neoplasms.
Mete O, Wenig BM
Head Neck Pathol 2022 Mar;16(1):123-142. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01435-8. PMID: 35312985Free PMC Article
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Large cell neuroendocrine carcinoma of the head and neck.
Kusafuka K, Ferlito A, Lewis JS Jr, Woolgar JA, Rinaldo A, Slootweg PJ, Gnepp DR, Devaney KO, Travis WD, Barnes L
Oral Oncol 2012 Mar;48(3):211-5. Epub 2011 Oct 22 doi: 10.1016/j.oraloncology.2011.09.016. PMID: 22024350

Therapy

Disease and toxicity outcomes for a modern cohort of patients with squamous cell carcinoma of cutaneous origin involving the parotid gland: Comparison of volumetric modulated arc therapy and pencil beam scanning proton therapy.
Zarinshenas R, Campbell P, Sun K, Molitoris JK, Patel AN, Witek ME, Cullen KJ, Mehra R, Hatten KM, Moyer KF, Taylor RJ, Vakharia KT, Wolf JS, Ferris MJ
Radiother Oncol 2024 Apr;193:110112. Epub 2024 Feb 1 doi: 10.1016/j.radonc.2024.110112. PMID: 38309587
Primary ductal adenocarcinoma of the lacrimal sac: the first reported case.
Ishida M, Iwai M, Yoshida K, Kagotani A, Kohzaki H, Arikata M, Shimizu T, Okabe H
Int J Clin Exp Pathol 2013;6(9):1929-34. Epub 2013 Aug 15 PMID: 24040460Free PMC Article
Salivary gland cancers: biology and molecular targets for therapy.
Bell D, Hanna EY
Curr Oncol Rep 2012 Apr;14(2):166-74. doi: 10.1007/s11912-012-0220-5. PMID: 22246609
Salivary gland cancers: current treatments, molecular characteristics and new therapies.
Chandana SR, Conley BA
Expert Rev Anticancer Ther 2008 Apr;8(4):645-52. doi: 10.1586/14737140.8.4.645. PMID: 18402531
Experience with CHART.
Saunders MI, Dische S, Grosch EJ, Fermont DC, Ashford RF, Maher EJ, Makepeace AR
Int J Radiat Oncol Biol Phys 1991 Aug;21(3):871-8. doi: 10.1016/0360-3016(91)90722-g. PMID: 1651312

Prognosis

Salivary Gland Secretory Carcinoma: Clinicopathologic and Genetic Characteristics of 215 Cases and Proposal for a Grading System.
Baněčková M, Thompson LDR, Hyrcza MD, Vaněček T, Agaimy A, Laco J, Simpson RHW, Di Palma S, Stevens TM, Brcic L, Etebarian A, Dimnik K, Majewska H, Stárek I, O'Regan E, Salviato T, Helliwell T, Horáková M, Biernat W, Onyuma T, Michal M, Leivo I, Skalova A
Am J Surg Pathol 2023 Jun 1;47(6):661-677. Epub 2023 Apr 18 doi: 10.1097/PAS.0000000000002043. PMID: 37070739
EBV Association with Lymphomas and Carcinomas in the Oral Compartment.
Ward BJH, Schaal DL, Nkadi EH, Scott RS
Viruses 2022 Dec 1;14(12) doi: 10.3390/v14122700. PMID: 36560704Free PMC Article
Newly Described Entities in Salivary Gland Pathology.
Skálová A, Gnepp DR, Lewis JS Jr, Hunt JL, Bishop JA, Hellquist H, Rinaldo A, Vander Poorten V, Ferlito A
Am J Surg Pathol 2017 Aug;41(8):e33-e47. doi: 10.1097/PAS.0000000000000883. PMID: 28614209
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Large cell neuroendocrine carcinoma of the head and neck.
Kusafuka K, Ferlito A, Lewis JS Jr, Woolgar JA, Rinaldo A, Slootweg PJ, Gnepp DR, Devaney KO, Travis WD, Barnes L
Oral Oncol 2012 Mar;48(3):211-5. Epub 2011 Oct 22 doi: 10.1016/j.oraloncology.2011.09.016. PMID: 22024350

Clinical prediction guides

Salivary Gland Secretory Carcinoma: Clinicopathologic and Genetic Characteristics of 215 Cases and Proposal for a Grading System.
Baněčková M, Thompson LDR, Hyrcza MD, Vaněček T, Agaimy A, Laco J, Simpson RHW, Di Palma S, Stevens TM, Brcic L, Etebarian A, Dimnik K, Majewska H, Stárek I, O'Regan E, Salviato T, Helliwell T, Horáková M, Biernat W, Onyuma T, Michal M, Leivo I, Skalova A
Am J Surg Pathol 2023 Jun 1;47(6):661-677. Epub 2023 Apr 18 doi: 10.1097/PAS.0000000000002043. PMID: 37070739
EBV Association with Lymphomas and Carcinomas in the Oral Compartment.
Ward BJH, Schaal DL, Nkadi EH, Scott RS
Viruses 2022 Dec 1;14(12) doi: 10.3390/v14122700. PMID: 36560704Free PMC Article
An organoid library of salivary gland tumors reveals subtype-specific characteristics and biomarkers.
Wang B, Gan J, Liu Z, Hui Z, Wei J, Gu X, Mu Y, Zang G
J Exp Clin Cancer Res 2022 Dec 17;41(1):350. doi: 10.1186/s13046-022-02561-5. PMID: 36527158Free PMC Article
Predictors of outcomes in large cell undifferentiated carcinoma of the major salivary glands.
Schrank TP, Zhan KY, Lentsch EJ
Laryngoscope 2017 Feb;127(2):372-376. Epub 2016 Aug 22 doi: 10.1002/lary.26136. PMID: 27545825
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

Recent systematic reviews

Prognostic role of PD-L1 expression in patients with salivary gland carcinoma: A systematic review and meta-analysis.
Wu L, Jiang C, Zhu Z, Sun Y, Zhang T
PLoS One 2022;17(7):e0272080. Epub 2022 Jul 26 doi: 10.1371/journal.pone.0272080. PMID: 35881656Free PMC Article

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