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Spindle cell lipoma

MedGen UID:
83153
•Concept ID:
C0334474
•
Neoplastic Process
Synonyms: Spindle Cell Lipoma; spindle cell lipoma; spindle cell lipoma (morphologic abnormality)
SNOMED CT: Spindle cell lipoma (404058008); Spindle cell lipoma (27313007)
 
Monarch Initiative: MONDO:0000962

Definition

A benign circumscribed tumor composed of spindled cells, adipocytes, and collagen bundles. There is no evidence of nuclear hyperchromasia or mitotic activity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpindle cell lipoma

Professional guidelines

PubMed

The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
From head and neck lipoma to liposarcoma: a wide spectrum of differential diagnoses and their therapeutic implications.
Barisella M, Giannini L, Piazza C
Curr Opin Otolaryngol Head Neck Surg 2020 Apr;28(2):136-143. doi: 10.1097/MOO.0000000000000608. PMID: 32011399
Differential Diagnosis of Benign Spindle Cell Lesions.
Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661

Recent clinical studies

Etiology

Hypopharyngeal spindle cell lipoma: A case report and review of literature.
Liang Z, Zang Y, Jing Z, Zhang Y, Cao H, Zhou H
Medicine (Baltimore) 2021 May 7;100(18):e25782. doi: 10.1097/MD.0000000000025782. PMID: 33950973Free PMC Article
Spindle cell lipoma.
Pardhe N, Singh N, Bharadwaj G, Nayak PA
BMJ Case Rep 2013 Aug 13;2013 doi: 10.1136/bcr-2013-010438. PMID: 23946512Free PMC Article
Spindle cell lipoma.
Comunoglu N, Comunoglu C, Ekici AI, Ozkan F, Dervişoglu S
Pol J Pathol 2007;58(1):7-11. PMID: 17585537
Spindle cell lipoma.
Angervall L, Dahl I, Kindblom LG, Säve-Söderbergh
Acta Pathol Microbiol Scand A 1976 Nov;84(6):477-87. doi: 10.1111/j.1699-0463.1976.tb00145.x. PMID: 998247
Spindle cell lipoma.
Enzinger FM, Harvey DA
Cancer 1975 Nov;36(5):1852-9. doi: 10.1002/1097-0142(197511)36:5<1852::aid-cncr2820360542>3.0.co;2-u. PMID: 1192370

Diagnosis

Esophageal spindle cell lipoma.
Val-Bernal JF, Mayorga MM, Fontanil N, Terán Á
Rom J Morphol Embryol 2021 Oct-Dec;62(4):1051-1055. doi: 10.47162/RJME.62.4.18. PMID: 35673825Free PMC Article
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Imaging of spindle cell lipoma.
Jelinek JS, Wu A, Wallace M, Kumar D, Henshaw RM, Murphey MJ, Van Horn A, Aboulafia AJ
Clin Radiol 2020 May;75(5):396.e15-396.e21. Epub 2020 Jan 10 doi: 10.1016/j.crad.2019.11.020. PMID: 31932047
Updates in spindle cell/pleomorphic lipomas.
Van Treeck BJ, Fritchie KJ
Semin Diagn Pathol 2019 Mar;36(2):105-111. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.005. PMID: 30850230
Differential Diagnosis of Benign Spindle Cell Lesions.
Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661

Therapy

Cutaneous side effects in a cohort of patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: General description and further characterization, correlation with photoexposition and study of hypopigmentation as treatment's prognostic factor.
Llamas-Velasco M, Ovejero-Merino E, García-Diez A, Requena L, Daudén E, Steegmann JL
Dermatol Ther 2020 Nov;33(6):e14428. Epub 2020 Nov 3 doi: 10.1111/dth.14428. PMID: 33073453
Loss of retinoblastoma in pleomorphic fibroma: An immunohistochemical and genomic analysis.
Hinds B, Agulló Pérez AD, LeBoit PE, McCalmont TH, North JP
J Cutan Pathol 2017 Aug;44(8):665-671. Epub 2017 Jun 13 doi: 10.1111/cup.12965. PMID: 28543636
Selected case from the Arkadi M. Rywlin International Pathology Slide Seminar: sclerotic (fibroma-like) lipoma, dorsum of right hand.
Allen PW
Adv Anat Pathol 2013 Jan;20(1):68-72. doi: 10.1097/PAP.0b013e31827b65e3. PMID: 23232574
Sinonasal and nasopharyngeal applications of the hand-held CO2 laser fiber.
Agarwal G, Kupferman ME, Holsinger FC, Hanna EY
Int Forum Allergy Rhinol 2011 Mar-Apr;1(2):109-12. doi: 10.1002/alr.20017. PMID: 22287328

Prognosis

The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Practical approach to diagnosis of bland-looking spindle cell lesions of the breast.
Magro G, Salvatorelli L, Puzzo L, Piombino E, Bartoloni G, Broggi G, Vecchio GM
Pathologica 2019 Dec;111(4):344-360. doi: 10.32074/1591-951X-31-19. PMID: 31965112Free PMC Article
Spindle cell lipoma of the hypopharynx.
Evcimik MF, Ozkurt FE, Sapci T, Bozkurt Z
Int J Med Sci 2011;8(6):479-81. Epub 2011 Aug 6 doi: 10.7150/ijms.8.479. PMID: 21850199Free PMC Article
Spindle cell lipoma.
Angervall L, Dahl I, Kindblom LG, Säve-Söderbergh
Acta Pathol Microbiol Scand A 1976 Nov;84(6):477-87. doi: 10.1111/j.1699-0463.1976.tb00145.x. PMID: 998247
Spindle cell lipoma.
Enzinger FM, Harvey DA
Cancer 1975 Nov;36(5):1852-9. doi: 10.1002/1097-0142(197511)36:5<1852::aid-cncr2820360542>3.0.co;2-u. PMID: 1192370

Clinical prediction guides

Histopathologic and genetic findings in atypical spindle cell/pleomorphic lipomatous tumors and atypical pleomorphic fibromas.
Kouhsari LM, LeBoit PE, McCalmont TH, Hinds B, North JP
J Cutan Pathol 2022 Jul;49(7):623-631. Epub 2022 Apr 5 doi: 10.1111/cup.14230. PMID: 35332938
Spindle Cell Lipoma with Ossification Mimicking Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma: A Case Report.
Ichikawa J, Kawasaki T, Imada H, Enomoto A, Taniguchi N, Tatsuno R, Kanno S, Haro H
Int J Surg Pathol 2022 Jun;30(4):413-418. Epub 2021 Nov 23 doi: 10.1177/10668969211055798. PMID: 34812072
Spindle Cell Lipoma Revisited: Common and Unusual Magnetic Resonance Imaging Findings in 54 Patients With New Observations.
Kumar R, Lefkowitz RA, Agaram NP, Amini B, Satcher RL, Wang WL
J Comput Assist Tomogr 2021 Jul-Aug 01;45(4):564-570. doi: 10.1097/RCT.0000000000001161. PMID: 34270478
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Spindle cell lipoma.
Angervall L, Dahl I, Kindblom LG, Säve-Söderbergh
Acta Pathol Microbiol Scand A 1976 Nov;84(6):477-87. doi: 10.1111/j.1699-0463.1976.tb00145.x. PMID: 998247

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