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Low Grade Vaginal Intraepithelial Neoplasia

MedGen UID:
83886
•Concept ID:
C0349554
•
Neoplastic Process
Synonyms: Grade 1 Vaginal Intraepithelial Neoplasia; Grade I Vaginal Intraepithelial Neoplasia; Intraepithelial Neoplasia of the Vagina Grade 1; Intraepithelial Neoplasia of Vagina Grade 1; Low Grade Vaginal Squamous Intraepithelial Lesion; Low Grade VAIN; Low-Grade Vaginal Squamous Intraepithelial Lesion; Mild vaginal dysplasia; Vaginal intraepithelial neoplasia grade 1; Vaginal Intraepithelial Neoplasia Grade 1; Vaginal Low Grade Squamous Intraepithelial Lesion; Vaginal Low-Grade Squamous Intraepithelial Lesion; Vaginal LSIL; VAIN - Vaginal intraepithelial neoplasia 1; VAIN Grade 1
SNOMED CT: Vaginal intraepithelial neoplasia grade 1 (276871002); VAIN - Vaginal intraepithelial neoplasia 1 (276871002); Mild vaginal dysplasia (276871002)

Definition

Vaginal intraepithelial neoplasia characterized by the presence of koilocytosis and disorganization and thickening of the basal layer. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow Grade Vaginal Intraepithelial Neoplasia

Professional guidelines

PubMed

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) consensus statement on the management of vaginal intraepithelial neoplasia.
Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
Role of human papillomavirus (HPV) vaccination on HPV infection and recurrence of HPV related disease after local surgical treatment: systematic review and meta-analysis.
Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Risk Estimates Supporting the 2019 ASCCP Risk-Based Management Consensus Guidelines.
Egemen D, Cheung LC, Chen X, Demarco M, Perkins RB, Kinney W, Poitras N, Befano B, Locke A, Guido RS, Wiser AL, Gage JC, Katki HA, Wentzensen N, Castle PE, Schiffman M, Lorey TS
J Low Genit Tract Dis 2020 Apr;24(2):132-143. doi: 10.1097/LGT.0000000000000529. PMID: 32243308Free PMC Article

Recent clinical studies

Etiology

Comparison of ALA-PDT and CO(2) laser treatment of low-grade vaginal intraepithelial neoplasia with high-risk HPV infection: A non-randomized controlled pilot study.
Wang L, Liu X, Zhang J, Li H, Wang X, Fu Y, Liu H, Xu Y, Meng L, Cui B, Zhang Y, Jia L
Photodiagnosis Photodyn Ther 2023 Sep;43:103695. Epub 2023 Jul 6 doi: 10.1016/j.pdpdt.2023.103695. PMID: 37422201
Feasibility study of 5-aminolevulinic acid mediated photodynamic therapy of persistent vaginal high-risk HPV infection of post-hysterectomy patients.
Huang J, Wei Y, Gu L, Di W, Hong Z, Qiu L
Photodiagnosis Photodyn Ther 2023 Mar;41:103250. Epub 2022 Dec 21 doi: 10.1016/j.pdpdt.2022.103250. PMID: 36565730
Photodynamic therapy combined with carbon dioxide laser for low-grade vaginal intraepithelial neoplasia: A retrospective analysis.
Yao H, Zhang H, Pu X, Shi L, Zhang Y, Wang P, Zhang G, Zhou Z, Zhou W, Wang X
Photodiagnosis Photodyn Ther 2020 Jun;30:101731. Epub 2020 May 11 doi: 10.1016/j.pdpdt.2020.101731. PMID: 32171880
A novel genital human papillomavirus (HPV), HPV type 74, found in immunosuppressed patients.
Longuet M, Cassonnet P, Orth G
J Clin Microbiol 1996 Jul;34(7):1859-62. doi: 10.1128/JCM.34.7.1859-1862.1996. PMID: 8784613Free PMC Article

Therapy

Comparison of ALA-PDT and CO(2) laser treatment of low-grade vaginal intraepithelial neoplasia with high-risk HPV infection: A non-randomized controlled pilot study.
Wang L, Liu X, Zhang J, Li H, Wang X, Fu Y, Liu H, Xu Y, Meng L, Cui B, Zhang Y, Jia L
Photodiagnosis Photodyn Ther 2023 Sep;43:103695. Epub 2023 Jul 6 doi: 10.1016/j.pdpdt.2023.103695. PMID: 37422201
Feasibility study of 5-aminolevulinic acid mediated photodynamic therapy of persistent vaginal high-risk HPV infection of post-hysterectomy patients.
Huang J, Wei Y, Gu L, Di W, Hong Z, Qiu L
Photodiagnosis Photodyn Ther 2023 Mar;41:103250. Epub 2022 Dec 21 doi: 10.1016/j.pdpdt.2022.103250. PMID: 36565730
Photodynamic therapy combined with carbon dioxide laser for low-grade vaginal intraepithelial neoplasia: A retrospective analysis.
Yao H, Zhang H, Pu X, Shi L, Zhang Y, Wang P, Zhang G, Zhou Z, Zhou W, Wang X
Photodiagnosis Photodyn Ther 2020 Jun;30:101731. Epub 2020 May 11 doi: 10.1016/j.pdpdt.2020.101731. PMID: 32171880
A novel genital human papillomavirus (HPV), HPV type 74, found in immunosuppressed patients.
Longuet M, Cassonnet P, Orth G
J Clin Microbiol 1996 Jul;34(7):1859-62. doi: 10.1128/JCM.34.7.1859-1862.1996. PMID: 8784613Free PMC Article

Clinical prediction guides

Photodynamic therapy combined with carbon dioxide laser for low-grade vaginal intraepithelial neoplasia: A retrospective analysis.
Yao H, Zhang H, Pu X, Shi L, Zhang Y, Wang P, Zhang G, Zhou Z, Zhou W, Wang X
Photodiagnosis Photodyn Ther 2020 Jun;30:101731. Epub 2020 May 11 doi: 10.1016/j.pdpdt.2020.101731. PMID: 32171880

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