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Mild epithelial dysplasia

MedGen UID:
90741
•Concept ID:
C0334058
•
Cell or Molecular Dysfunction
Synonyms: Grade 1 Intraepithelial Neoplasia; Grade I Intraepithelial Neoplasia; Low Grade Intraepithelial Neoplasia; Mild Epithelial Dysplasia
SNOMED CT: Mild epithelial dysplasia (33288004)

Definition

A precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. It is characterized by the presence of mild epithelial dysplasia. [from NCI]

Professional guidelines

PubMed

1% Tirbanibulin Ointment for the Treatment of Actinic Keratoses.
Dao DD, Sahni VN, Sahni DR, Balogh EA, Grada A, Feldman SR
Ann Pharmacother 2022 Apr;56(4):494-500. Epub 2021 Jul 23 doi: 10.1177/10600280211031329. PMID: 34301153Free PMC Article
Management of Laryngeal Dysplasia and Early Invasive Cancer.
Hrelec C
Curr Treat Options Oncol 2021 Aug 23;22(10):90. doi: 10.1007/s11864-021-00881-w. PMID: 34424405
Management of epithelial precancerous conditions and lesions in the stomach (MAPS II): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG), European Society of Pathology (ESP), and Sociedade Portuguesa de Endoscopia Digestiva (SPED) guideline update 2019.
Pimentel-Nunes P, Libânio D, Marcos-Pinto R, Areia M, Leja M, Esposito G, Garrido M, Kikuste I, Megraud F, Matysiak-Budnik T, Annibale B, Dumonceau JM, Barros R, Fléjou JF, Carneiro F, van Hooft JE, Kuipers EJ, Dinis-Ribeiro M
Endoscopy 2019 Apr;51(4):365-388. Epub 2019 Mar 6 doi: 10.1055/a-0859-1883. PMID: 30841008

Recent clinical studies

Etiology

Histopathological and risk factor analyses of oral potentially malignant disorders and oral cancer in a proactive screening in northeastern Thailand.
Klongnoi B, Sresumatchai V, Clypuing H, Wisutthajaree A, Pankam J, Srimaneekarn N, Shrestha B, Khovidhunkit SP
BMC Oral Health 2022 Dec 16;22(1):613. doi: 10.1186/s12903-022-02646-9. PMID: 36527041Free PMC Article
Actinic cheilitis: Proposal of a clinical index.
Medeiros CK, Lopes ML, Silveira ÉJ, Lima KC, Oliveira PT
Med Oral Patol Oral Cir Bucal 2022 Jul 1;27(4):e310-e318. doi: 10.4317/medoral.25243. PMID: 35660729Free PMC Article
Suitability/unsuitability of cell proliferation as an indicator of malignant potential in oral lichen planus: an immunohistochemical study.
Zargaran M, Jamshidi S, Eshghyar N, Moghimbeigi A
Asian Pac J Cancer Prev 2013;14(11):6979-83. doi: 10.7314/apjcp.2013.14.11.6979. PMID: 24377636
Overexpression of Smad proteins, especially Smad7, in oral epithelial dysplasias.
Chen YK, Huang AH, Cheng PH, Yang SH, Lin LM
Clin Oral Investig 2013 Apr;17(3):921-32. Epub 2012 Jun 6 doi: 10.1007/s00784-012-0756-7. PMID: 22669485
Cell proliferation and tumour suppressor gene expression in iodine unstained area surrounding oral squamous cell carcinoma.
Yokoo K, Noma H, Inoue T, Hashimoto S, Shimono M
Int J Oral Maxillofac Surg 2004 Jan;33(1):75-83. doi: 10.1054/ijom.2002.0457. PMID: 14690663

Diagnosis

Histopathological and risk factor analyses of oral potentially malignant disorders and oral cancer in a proactive screening in northeastern Thailand.
Klongnoi B, Sresumatchai V, Clypuing H, Wisutthajaree A, Pankam J, Srimaneekarn N, Shrestha B, Khovidhunkit SP
BMC Oral Health 2022 Dec 16;22(1):613. doi: 10.1186/s12903-022-02646-9. PMID: 36527041Free PMC Article
Actinic cheilitis: Proposal of a clinical index.
Medeiros CK, Lopes ML, Silveira ÉJ, Lima KC, Oliveira PT
Med Oral Patol Oral Cir Bucal 2022 Jul 1;27(4):e310-e318. doi: 10.4317/medoral.25243. PMID: 35660729Free PMC Article
Digital analysis and quantitative assessment of the cervical surface with dysplasia.
Dushkin AD, Afanasiev MS, Zatevalov AM, Aleshkin VA, Mironov AY, Afanasiev SS, Nesvizhsky YV, Borisova OY, Grishacheva TG, Karaulov AV
Klin Lab Diagn 2021 Jul 16;66(7):417-421. doi: 10.51620/0869-2084-2021-66-7-417-421. PMID: 34292684
Modified Cajal's trichrome stain as a diagnostic aid in the study of epithelial pathology.
Sanjai K, Baker A, Reddy LP, Pandey B
Indian J Pathol Microbiol 2017 Oct-Dec;60(4):528-532. doi: 10.4103/IJPM.IJPM_202_16. PMID: 29323067
The severity of epithelial dysplasia is associated with loss of maspin expression in actinic cheilitis.
Fontes A, de Sousa SM, dos Santos E, Martins MT
J Cutan Pathol 2009 Nov;36(11):1151-6. Epub 2009 Feb 12 doi: 10.1111/j.1600-0560.2009.01243.x. PMID: 19222699

Therapy

Smokeless tobacco keratosis in oral mucosa with epithelial dysplasia: A case report.
Kaabi HH
Medicine (Baltimore) 2024 Apr 12;103(15):e37771. doi: 10.1097/MD.0000000000037771. PMID: 38608125Free PMC Article
Clinical evaluation of Lugol's iodine staining in the treatment of stage I-II squamous cell carcinoma of the tongue.
Umeda M, Shigeta T, Takahashi H, Minamikawa T, Komatsubara H, Oguni A, Shibuya Y, Komori T
Int J Oral Maxillofac Surg 2011 Jun;40(6):593-6. Epub 2011 Feb 21 doi: 10.1016/j.ijom.2010.11.026. PMID: 21334851
Effective staining method with iodine for leukoplakia and lesions surrounding squamous cell carcinomas of the tongue assessed by colorimetric analysis.
Maeda K, Yamashiro M, Michi Y, Suzuki T, Ohyama Y, Okada N, Amagasa T
J Med Dent Sci 2009 Dec;56(4):123-30. PMID: 20432796
The severity of epithelial dysplasia is associated with loss of maspin expression in actinic cheilitis.
Fontes A, de Sousa SM, dos Santos E, Martins MT
J Cutan Pathol 2009 Nov;36(11):1151-6. Epub 2009 Feb 12 doi: 10.1111/j.1600-0560.2009.01243.x. PMID: 19222699
Expression of keratin 13, 14 and 19 in oral hyperplastic and dysplastic lesions from Sudanese and Swedish snuff-dippers: association with human papillomavirus infection.
Ibrahim SO, Warnakulasuriya KA, Idris AM, Hirsch JM, Johnson NW, Johannessen AC
Anticancer Res 1998 Jan-Feb;18(1B):635-45. PMID: 9584046

Prognosis

Actinic cheilitis: Proposal of a clinical index.
Medeiros CK, Lopes ML, Silveira ÉJ, Lima KC, Oliveira PT
Med Oral Patol Oral Cir Bucal 2022 Jul 1;27(4):e310-e318. doi: 10.4317/medoral.25243. PMID: 35660729Free PMC Article
Digital analysis and quantitative assessment of the cervical surface with dysplasia.
Dushkin AD, Afanasiev MS, Zatevalov AM, Aleshkin VA, Mironov AY, Afanasiev SS, Nesvizhsky YV, Borisova OY, Grishacheva TG, Karaulov AV
Klin Lab Diagn 2021 Jul 16;66(7):417-421. doi: 10.51620/0869-2084-2021-66-7-417-421. PMID: 34292684
Suitability/unsuitability of cell proliferation as an indicator of malignant potential in oral lichen planus: an immunohistochemical study.
Zargaran M, Jamshidi S, Eshghyar N, Moghimbeigi A
Asian Pac J Cancer Prev 2013;14(11):6979-83. doi: 10.7314/apjcp.2013.14.11.6979. PMID: 24377636
Clinical evaluation of Lugol's iodine staining in the treatment of stage I-II squamous cell carcinoma of the tongue.
Umeda M, Shigeta T, Takahashi H, Minamikawa T, Komatsubara H, Oguni A, Shibuya Y, Komori T
Int J Oral Maxillofac Surg 2011 Jun;40(6):593-6. Epub 2011 Feb 21 doi: 10.1016/j.ijom.2010.11.026. PMID: 21334851
Analysis of the tissue marker AgNOR in leukoplaquia and oral squamous cell carcinoma.
Cano Montoya LC, Alvarez Gómez GJ, Valencia Londoño WA, Ramírez España JA, Prada Navas CA
Med Oral 2002 Jan-Feb;7(1):17-21, 22-5. PMID: 11788805

Clinical prediction guides

Histopathological and risk factor analyses of oral potentially malignant disorders and oral cancer in a proactive screening in northeastern Thailand.
Klongnoi B, Sresumatchai V, Clypuing H, Wisutthajaree A, Pankam J, Srimaneekarn N, Shrestha B, Khovidhunkit SP
BMC Oral Health 2022 Dec 16;22(1):613. doi: 10.1186/s12903-022-02646-9. PMID: 36527041Free PMC Article
Actinic cheilitis: Proposal of a clinical index.
Medeiros CK, Lopes ML, Silveira ÉJ, Lima KC, Oliveira PT
Med Oral Patol Oral Cir Bucal 2022 Jul 1;27(4):e310-e318. doi: 10.4317/medoral.25243. PMID: 35660729Free PMC Article
Digital analysis and quantitative assessment of the cervical surface with dysplasia.
Dushkin AD, Afanasiev MS, Zatevalov AM, Aleshkin VA, Mironov AY, Afanasiev SS, Nesvizhsky YV, Borisova OY, Grishacheva TG, Karaulov AV
Klin Lab Diagn 2021 Jul 16;66(7):417-421. doi: 10.51620/0869-2084-2021-66-7-417-421. PMID: 34292684
Overexpression of Smad proteins, especially Smad7, in oral epithelial dysplasias.
Chen YK, Huang AH, Cheng PH, Yang SH, Lin LM
Clin Oral Investig 2013 Apr;17(3):921-32. Epub 2012 Jun 6 doi: 10.1007/s00784-012-0756-7. PMID: 22669485
The severity of epithelial dysplasia is associated with loss of maspin expression in actinic cheilitis.
Fontes A, de Sousa SM, dos Santos E, Martins MT
J Cutan Pathol 2009 Nov;36(11):1151-6. Epub 2009 Feb 12 doi: 10.1111/j.1600-0560.2009.01243.x. PMID: 19222699

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