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Intervillous Thrombus

MedGen UID:
858305
•Concept ID:
C3898711
•
Finding

Definition

A focus of maternal thrombus within the intervillous space, often with peripheral villous compression. The clot may be wholly or minimally laminated reflecting age. [from NCI]

Professional guidelines

PubMed

Platelet protease activated receptor 4 (PAR 4) receptor genotype is associated with an increased risk of preterm birth.
Boelig RC, Cahanap TJ, Ma L, Zhan T, Berghella V, Chan JSY, Kraft WK, Mckenzie SE
J Thromb Haemost 2022 Oct;20(10):2419-2428. Epub 2022 Jul 31 doi: 10.1111/jth.15814. PMID: 35815338
Clinical significance and treatment of massive intervillous fibrin deposition associated with recurrent fetal growth retardation.
Fuke Y, Aono T, Imai S, Suehara N, Fujita T, Nakayama M
Gynecol Obstet Invest 1994;38(1):5-9. doi: 10.1159/000292434. PMID: 7959327

Recent clinical studies

Etiology

Ferumoxytol-enhanced MR demonstration of changes to internal placental structure in placenta accreta spectrum: Preliminary findings.
Kliewer MA, Bockoven CG, Reeder SB, Bagley AR, Sadowski EA, Iruretagoyena JI, Beninati MJ, Fritsch MK
Placenta 2023 Mar 24;134:1-8. Epub 2023 Feb 10 doi: 10.1016/j.placenta.2023.02.003. PMID: 36807998
Shallow Placentation: A Distinct Category of Placental Lesions.
Stanek J
Am J Perinatol 2023 Sep;40(12):1328-1335. Epub 2021 Sep 29 doi: 10.1055/s-0041-1735554. PMID: 34587634
Placental findings associated with maternal obesity at early pregnancy.
He M, Curran P, Raker C, Martin S, Larson L, Bourjeily G
Pathol Res Pract 2016 Apr;212(4):282-7. Epub 2016 Jan 23 doi: 10.1016/j.prp.2016.01.006. PMID: 26861722
Prevalence of Intervillous Thrombi Is Increased in Placentas from Pregnancies Complicated by Diabetes.
Basnet KM, Bentley-Lewis R, Wexler DJ, Kilic F, Roberts DJ
Pediatr Dev Pathol 2016 Nov/Dec;19(6):502-505. Epub 2015 Dec 15 doi: 10.2350/15-11-1734-OA.1. PMID: 26669929
Rounded intraplacental haematomas due to decidual vasculopathy have a distinctive morphology.
Fitzgerald B, Shannon P, Kingdom J, Keating S
J Clin Pathol 2011 Aug;64(8):729-32. Epub 2011 Mar 1 doi: 10.1136/jcp.2010.087916. PMID: 21367756

Diagnosis

Ferumoxytol-enhanced MR demonstration of changes to internal placental structure in placenta accreta spectrum: Preliminary findings.
Kliewer MA, Bockoven CG, Reeder SB, Bagley AR, Sadowski EA, Iruretagoyena JI, Beninati MJ, Fritsch MK
Placenta 2023 Mar 24;134:1-8. Epub 2023 Feb 10 doi: 10.1016/j.placenta.2023.02.003. PMID: 36807998
Shallow Placentation: A Distinct Category of Placental Lesions.
Stanek J
Am J Perinatol 2023 Sep;40(12):1328-1335. Epub 2021 Sep 29 doi: 10.1055/s-0041-1735554. PMID: 34587634
Relationship between placental morphology and histological findings in an unselected population near term.
Pathak S, Sebire NJ, Hook L, Hackett G, Murdoch E, Jessop F, Lees C
Virchows Arch 2011 Jul;459(1):11-20. Epub 2011 Apr 12 doi: 10.1007/s00428-011-1061-6. PMID: 21484432
Diagnosis of placental abruption: relationship between clinical and histopathological findings.
Elsasser DA, Ananth CV, Prasad V, Vintzileos AM; New Jersey-Placental Abruption Study Investigators
Eur J Obstet Gynecol Reprod Biol 2010 Feb;148(2):125-30. Epub 2009 Nov 7 doi: 10.1016/j.ejogrb.2009.10.005. PMID: 19897298Free PMC Article
Discrepancy in pathologic diagnosis of placental lesions.
Sun CC, Revell VO, Belli AJ, Viscardi RM
Arch Pathol Lab Med 2002 Jun;126(6):706-9. doi: 10.5858/2002-126-0706-DIPDOP. PMID: 12033960

Therapy

Shallow Placentation: A Distinct Category of Placental Lesions.
Stanek J
Am J Perinatol 2023 Sep;40(12):1328-1335. Epub 2021 Sep 29 doi: 10.1055/s-0041-1735554. PMID: 34587634
Placental findings associated with maternal obesity at early pregnancy.
He M, Curran P, Raker C, Martin S, Larson L, Bourjeily G
Pathol Res Pract 2016 Apr;212(4):282-7. Epub 2016 Jan 23 doi: 10.1016/j.prp.2016.01.006. PMID: 26861722
The influence of maternal cigarette smoking on placental pathology in pregnancies complicated by abruption.
Kaminsky LM, Ananth CV, Prasad V, Nath C, Vintzileos AM; New Jersey Placental Abruption Study Investigators
Am J Obstet Gynecol 2007 Sep;197(3):275.e1-5. doi: 10.1016/j.ajog.2007.06.026. PMID: 17826418Free PMC Article

Prognosis

Machine learning classification of placental villous infarction, perivillous fibrin deposition, and intervillous thrombus.
Goldstein JA, Nateghi R, Irmakci I, Cooper LAD
Placenta 2023 Apr;135:43-50. Epub 2023 Mar 15 doi: 10.1016/j.placenta.2023.03.003. PMID: 36958179Free PMC Article
Relationship between placental morphology and histological findings in an unselected population near term.
Pathak S, Sebire NJ, Hook L, Hackett G, Murdoch E, Jessop F, Lees C
Virchows Arch 2011 Jul;459(1):11-20. Epub 2011 Apr 12 doi: 10.1007/s00428-011-1061-6. PMID: 21484432

Clinical prediction guides

Relationship between placental morphology and histological findings in an unselected population near term.
Pathak S, Sebire NJ, Hook L, Hackett G, Murdoch E, Jessop F, Lees C
Virchows Arch 2011 Jul;459(1):11-20. Epub 2011 Apr 12 doi: 10.1007/s00428-011-1061-6. PMID: 21484432
Discrepancy in pathologic diagnosis of placental lesions.
Sun CC, Revell VO, Belli AJ, Viscardi RM
Arch Pathol Lab Med 2002 Jun;126(6):706-9. doi: 10.5858/2002-126-0706-DIPDOP. PMID: 12033960

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