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Acute Intervillous Thrombus

MedGen UID:
859707
•Concept ID:
C3900113
•
Finding

Definition

A focus of maternal thrombus within the placental intervillous space, often with peripheral villous compression, which is less than 1-2 days in age. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute Intervillous Thrombus

Recent clinical studies

Etiology

Shallow Placentation: A Distinct Category of Placental Lesions.
Stanek J
Am J Perinatol 2023 Sep;40(12):1328-1335. Epub 2021 Sep 29 doi: 10.1055/s-0041-1735554. PMID: 34587634
Placental histopathology after SARS-CoV-2 infection in pregnancy: a systematic review and meta-analysis.
Di Girolamo R, Khalil A, Alameddine S, D'Angelo E, Galliani C, Matarrelli B, Buca D, Liberati M, Rizzo G, D'Antonio F
Am J Obstet Gynecol MFM 2021 Nov;3(6):100468. Epub 2021 Aug 21 doi: 10.1016/j.ajogmf.2021.100468. PMID: 34425296Free PMC Article
Altered fetal growth, placental abnormalities, and stillbirth.
Bukowski R, Hansen NI, Pinar H, Willinger M, Reddy UM, Parker CB, Silver RM, Dudley DJ, Stoll BJ, Saade GR, Koch MA, Hogue C, Varner MW, Conway DL, Coustan D, Goldenberg RL; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Stillbirth Collaborative Research Network (SCRN)
PLoS One 2017;12(8):e0182874. Epub 2017 Aug 18 doi: 10.1371/journal.pone.0182874. PMID: 28820889Free PMC Article
Placental hypoxic overlap lesions: a clinicoplacental correlation.
Stanek J
J Obstet Gynaecol Res 2015 Mar;41(3):358-69. Epub 2014 Oct 10 doi: 10.1111/jog.12539. PMID: 25762365
Discrepancy in pathologic diagnosis of placental lesions.
Sun CC, Revell VO, Belli AJ, Viscardi RM
Arch Pathol Lab Med 2002 Jun;126(6):706-9. doi: 10.5858/2002-126-0706-DIPDOP. PMID: 12033960

Diagnosis

Shallow Placentation: A Distinct Category of Placental Lesions.
Stanek J
Am J Perinatol 2023 Sep;40(12):1328-1335. Epub 2021 Sep 29 doi: 10.1055/s-0041-1735554. PMID: 34587634
Altered fetal growth, placental abnormalities, and stillbirth.
Bukowski R, Hansen NI, Pinar H, Willinger M, Reddy UM, Parker CB, Silver RM, Dudley DJ, Stoll BJ, Saade GR, Koch MA, Hogue C, Varner MW, Conway DL, Coustan D, Goldenberg RL; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Stillbirth Collaborative Research Network (SCRN)
PLoS One 2017;12(8):e0182874. Epub 2017 Aug 18 doi: 10.1371/journal.pone.0182874. PMID: 28820889Free PMC Article
Diagnosis of placental abruption: relationship between clinical and histopathological findings.
Elsasser DA, Ananth CV, Prasad V, Vintzileos AM; New Jersey-Placental Abruption Study Investigators
Eur J Obstet Gynecol Reprod Biol 2010 Feb;148(2):125-30. Epub 2009 Nov 7 doi: 10.1016/j.ejogrb.2009.10.005. PMID: 19897298Free PMC Article
Discrepancy in pathologic diagnosis of placental lesions.
Sun CC, Revell VO, Belli AJ, Viscardi RM
Arch Pathol Lab Med 2002 Jun;126(6):706-9. doi: 10.5858/2002-126-0706-DIPDOP. PMID: 12033960

Therapy

Shallow Placentation: A Distinct Category of Placental Lesions.
Stanek J
Am J Perinatol 2023 Sep;40(12):1328-1335. Epub 2021 Sep 29 doi: 10.1055/s-0041-1735554. PMID: 34587634
The effect of endometriosis on placental histopathology and perinatal outcome in singleton live births resulting from IVF.
Volodarsky-Perel A, Ton Nu TN, Mashiach R, Berkowitz E, Balayla J, Machado-Gedeon A, Cui Y, Shaul J, Dahan MH
Reprod Biomed Online 2022 Oct;45(4):754-761. Epub 2022 May 1 doi: 10.1016/j.rbmo.2022.04.015. PMID: 35989169
Placental histopathology after SARS-CoV-2 infection in pregnancy: a systematic review and meta-analysis.
Di Girolamo R, Khalil A, Alameddine S, D'Angelo E, Galliani C, Matarrelli B, Buca D, Liberati M, Rizzo G, D'Antonio F
Am J Obstet Gynecol MFM 2021 Nov;3(6):100468. Epub 2021 Aug 21 doi: 10.1016/j.ajogmf.2021.100468. PMID: 34425296Free PMC Article

Clinical prediction guides

Placental histopathology after SARS-CoV-2 infection in pregnancy: a systematic review and meta-analysis.
Di Girolamo R, Khalil A, Alameddine S, D'Angelo E, Galliani C, Matarrelli B, Buca D, Liberati M, Rizzo G, D'Antonio F
Am J Obstet Gynecol MFM 2021 Nov;3(6):100468. Epub 2021 Aug 21 doi: 10.1016/j.ajogmf.2021.100468. PMID: 34425296Free PMC Article
Altered fetal growth, placental abnormalities, and stillbirth.
Bukowski R, Hansen NI, Pinar H, Willinger M, Reddy UM, Parker CB, Silver RM, Dudley DJ, Stoll BJ, Saade GR, Koch MA, Hogue C, Varner MW, Conway DL, Coustan D, Goldenberg RL; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Stillbirth Collaborative Research Network (SCRN)
PLoS One 2017;12(8):e0182874. Epub 2017 Aug 18 doi: 10.1371/journal.pone.0182874. PMID: 28820889Free PMC Article
Discrepancy in pathologic diagnosis of placental lesions.
Sun CC, Revell VO, Belli AJ, Viscardi RM
Arch Pathol Lab Med 2002 Jun;126(6):706-9. doi: 10.5858/2002-126-0706-DIPDOP. PMID: 12033960

Recent systematic reviews

Placental histopathology after SARS-CoV-2 infection in pregnancy: a systematic review and meta-analysis.
Di Girolamo R, Khalil A, Alameddine S, D'Angelo E, Galliani C, Matarrelli B, Buca D, Liberati M, Rizzo G, D'Antonio F
Am J Obstet Gynecol MFM 2021 Nov;3(6):100468. Epub 2021 Aug 21 doi: 10.1016/j.ajogmf.2021.100468. PMID: 34425296Free PMC Article

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