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Adult Combined Hepatocellular Carcinoma and Cholangiocarcinoma

MedGen UID:
859699
•Concept ID:
C3900105
•
Neoplastic Process

Definition

A combined hepatocellular carcinoma and cholangiocarcinoma that occurs during adulthood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Combined Hepatocellular Carcinoma and Cholangiocarcinoma

Professional guidelines

PubMed

Intrahepatic cholangiocarcinoma and its differential diagnosis at MRI: how radiologist should assess MR features.
Granata V, Grassi R, Fusco R, Setola SV, Belli A, Ottaiano A, Nasti G, La Porta M, Danti G, Cappabianca S, Cutolo C, Petrillo A, Izzo F
Radiol Med 2021 Dec;126(12):1584-1600. Epub 2021 Nov 29 doi: 10.1007/s11547-021-01428-7. PMID: 34843029
Combined hepatocellular-cholangiocarcinoma: An update on epidemiology, classification, diagnosis and management.
Schizas D, Mastoraki A, Routsi E, Papapanou M, Tsapralis D, Vassiliu P, Toutouzas K, Felekouras E
Hepatobiliary Pancreat Dis Int 2020 Dec;19(6):515-523. Epub 2020 Jul 24 doi: 10.1016/j.hbpd.2020.07.004. PMID: 32753331
Combined hepatocellular carcinoma and cholangiocarcinoma: clinical features, treatment modalities, and prognosis.
Yin X, Zhang BH, Qiu SJ, Ren ZG, Zhou J, Chen XH, Zhou Y, Fan J
Ann Surg Oncol 2012 Sep;19(9):2869-76. Epub 2012 Mar 27 doi: 10.1245/s10434-012-2328-0. PMID: 22451237

Recent clinical studies

Etiology

Combined hepatocellular cholangiocarcinoma in hepatectomy specimens: A clinicopathologic analysis.
Patil N, Sahai P, Rastogi A, Sharma N, Shasthry SM, Mukund A, Laroia ST, Kumar G, Pamecha V, Sarin SK
Indian J Pathol Microbiol 2023 Oct-Dec;66(4):744-750. doi: 10.4103/ijpm.ijpm_357_22. PMID: 38084526
Computed Tomography Radiomics to Differentiate Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma.
Mahmoudi S, Bernatz S, Ackermann J, Koch V, Dos Santos DP, Grünewald LD, Yel I, Martin SS, Scholtz JE, Stehle A, Walter D, Zeuzem S, Wild PJ, Vogl TJ, Kinzler MN
Clin Oncol (R Coll Radiol) 2023 May;35(5):e312-e318. Epub 2023 Feb 1 doi: 10.1016/j.clon.2023.01.018. PMID: 36804153
Combined hepatocellular-cholangiocarcinoma and its mimickers: Diagnostic pitfalls in surgical pathology.
Laohawetwanit T, Lerttanatum N, Wanpiyarat N, Manasilp N, Chaiparnich S
Ann Diagn Pathol 2021 Aug;53:151770. Epub 2021 Jun 16 doi: 10.1016/j.anndiagpath.2021.151770. PMID: 34147845
Combined hepatocellular-cholangiocarcinoma: An update on epidemiology, classification, diagnosis and management.
Schizas D, Mastoraki A, Routsi E, Papapanou M, Tsapralis D, Vassiliu P, Toutouzas K, Felekouras E
Hepatobiliary Pancreat Dis Int 2020 Dec;19(6):515-523. Epub 2020 Jul 24 doi: 10.1016/j.hbpd.2020.07.004. PMID: 32753331
Radiological features and outcomes of combined hepatocellular-cholangiocarcinoma in patients undergoing surgical resection.
Chi CT, Chau GY, Lee RC, Chen YY, Lei HJ, Hou MC, Chao Y, Huang YH
J Formos Med Assoc 2020 Jan;119(1 Pt 1):125-133. Epub 2019 Mar 12 doi: 10.1016/j.jfma.2019.02.012. PMID: 30876788

Diagnosis

Computed Tomography Radiomics to Differentiate Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma.
Mahmoudi S, Bernatz S, Ackermann J, Koch V, Dos Santos DP, Grünewald LD, Yel I, Martin SS, Scholtz JE, Stehle A, Walter D, Zeuzem S, Wild PJ, Vogl TJ, Kinzler MN
Clin Oncol (R Coll Radiol) 2023 May;35(5):e312-e318. Epub 2023 Feb 1 doi: 10.1016/j.clon.2023.01.018. PMID: 36804153
Intrahepatic cholangiocarcinoma: Tumour heterogeneity and its clinical relevance.
Komuta M
Clin Mol Hepatol 2022 Jul;28(3):396-407. Epub 2022 Jan 14 doi: 10.3350/cmh.2021.0287. PMID: 35032970Free PMC Article
Combined hepatocellular-cholangiocarcinoma and its mimickers: Diagnostic pitfalls in surgical pathology.
Laohawetwanit T, Lerttanatum N, Wanpiyarat N, Manasilp N, Chaiparnich S
Ann Diagn Pathol 2021 Aug;53:151770. Epub 2021 Jun 16 doi: 10.1016/j.anndiagpath.2021.151770. PMID: 34147845
Combined hepatocellular-cholangiocarcinoma: An update on epidemiology, classification, diagnosis and management.
Schizas D, Mastoraki A, Routsi E, Papapanou M, Tsapralis D, Vassiliu P, Toutouzas K, Felekouras E
Hepatobiliary Pancreat Dis Int 2020 Dec;19(6):515-523. Epub 2020 Jul 24 doi: 10.1016/j.hbpd.2020.07.004. PMID: 32753331
Update on the pathology of liver neoplasms.
Matsukuma KE, Yeh MM
Ann Diagn Pathol 2019 Feb;38:126-137. Epub 2018 Oct 12 doi: 10.1016/j.anndiagpath.2018.10.005. PMID: 30597357

Therapy

Atezolizumab and bevacizumab for non-resectable or metastatic combined hepatocellular-cholangiocarcinoma: A multicentric retrospective study.
Gigante E, Bouattour M, Bedoya JU, Regnault H, Ziol M, Assenat E, Paradis V, Calderaro J, Ganne-Carrié N, Bouhier-Leporrier K, Amaddeo G, Nault JC
United European Gastroenterol J 2024 May;12(4):429-439. Epub 2023 Dec 7 doi: 10.1002/ueg2.12503. PMID: 38059651Free PMC Article
Clinical outcomes of immune checkpoint inhibitors in unresectable or metastatic combined hepatocellular-cholangiocarcinoma.
Jang YJ, Kim EJ, Kim HD, Kim KP, Ryu MH, Park SR, Choi WM, Lee D, Choi J, Shim JH, Kim KM, Lim YS, Lee HC, Ryoo BY, Yoo C
J Cancer Res Clin Oncol 2023 Aug;149(10):7547-7555. Epub 2023 Mar 27 doi: 10.1007/s00432-023-04704-3. PMID: 36971796
Locoregional Therapy of Hepatocellular-Cholangiocarcinoma versus Hepatocellular Carcinoma: A Propensity Score-Matched Study.
Huang YH, Park BV, Chen YF, Gaba RC, Guzman G, Lokken RP
J Vasc Interv Radiol 2019 Sep;30(9):1317-1324. Epub 2019 Jul 30 doi: 10.1016/j.jvir.2019.03.024. PMID: 31375450
Systemic Therapy for Combined Hepatocellular-Cholangiocarcinoma: A Single-Institution Experience.
Trikalinos NA, Zhou A, Doyle MBM, Fowler KJ, Morton A, Vachharajani N, Amin M, Keller JW, Chapman WC, Brunt EM, Tan BR
J Natl Compr Canc Netw 2018 Oct;16(10):1193-1199. doi: 10.6004/jnccn.2018.7053. PMID: 30323089
Yttrium-90 Radioembolization for Unresectable Combined Hepatocellular-Cholangiocarcinoma.
Chan LS, Sze DY, Poultsides GA, Louie JD, Abdelrazek Mohammed MA, Wang DS
Cardiovasc Intervent Radiol 2017 Sep;40(9):1383-1391. Epub 2017 Apr 21 doi: 10.1007/s00270-017-1648-7. PMID: 28432387

Prognosis

Computed Tomography Radiomics to Differentiate Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma.
Mahmoudi S, Bernatz S, Ackermann J, Koch V, Dos Santos DP, Grünewald LD, Yel I, Martin SS, Scholtz JE, Stehle A, Walter D, Zeuzem S, Wild PJ, Vogl TJ, Kinzler MN
Clin Oncol (R Coll Radiol) 2023 May;35(5):e312-e318. Epub 2023 Feb 1 doi: 10.1016/j.clon.2023.01.018. PMID: 36804153
Combined hepatocellular-cholangiocarcinoma and its mimickers: Diagnostic pitfalls in surgical pathology.
Laohawetwanit T, Lerttanatum N, Wanpiyarat N, Manasilp N, Chaiparnich S
Ann Diagn Pathol 2021 Aug;53:151770. Epub 2021 Jun 16 doi: 10.1016/j.anndiagpath.2021.151770. PMID: 34147845
Combined hepatocellular-cholangiocarcinoma: An update on epidemiology, classification, diagnosis and management.
Schizas D, Mastoraki A, Routsi E, Papapanou M, Tsapralis D, Vassiliu P, Toutouzas K, Felekouras E
Hepatobiliary Pancreat Dis Int 2020 Dec;19(6):515-523. Epub 2020 Jul 24 doi: 10.1016/j.hbpd.2020.07.004. PMID: 32753331
Patients' prognosis of intrahepatic cholangiocarcinoma and combined hepatocellular-cholangiocarcinoma after resection.
Song P, Midorikawa Y, Nakayama H, Higaki T, Moriguchi M, Aramaki O, Yamazaki S, Aoki M, Teramoto K, Takayama T
Cancer Med 2019 Oct;8(13):5862-5871. Epub 2019 Aug 13 doi: 10.1002/cam4.2495. PMID: 31407490Free PMC Article
Yttrium-90 Radioembolization for Unresectable Combined Hepatocellular-Cholangiocarcinoma.
Chan LS, Sze DY, Poultsides GA, Louie JD, Abdelrazek Mohammed MA, Wang DS
Cardiovasc Intervent Radiol 2017 Sep;40(9):1383-1391. Epub 2017 Apr 21 doi: 10.1007/s00270-017-1648-7. PMID: 28432387

Clinical prediction guides

Combined hepatocellular cholangiocarcinoma in hepatectomy specimens: A clinicopathologic analysis.
Patil N, Sahai P, Rastogi A, Sharma N, Shasthry SM, Mukund A, Laroia ST, Kumar G, Pamecha V, Sarin SK
Indian J Pathol Microbiol 2023 Oct-Dec;66(4):744-750. doi: 10.4103/ijpm.ijpm_357_22. PMID: 38084526
Prediction of microvascular invasion in combined hepatocellular-cholangiocarcinoma based on preoperative contrast-enhanced CT and clinical data.
Zhang J, Dong W, Li Y, Fu J, Jia N
Eur J Radiol 2023 Jun;163:110839. Epub 2023 Apr 20 doi: 10.1016/j.ejrad.2023.110839. PMID: 37121101
Computed Tomography Radiomics to Differentiate Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma.
Mahmoudi S, Bernatz S, Ackermann J, Koch V, Dos Santos DP, Grünewald LD, Yel I, Martin SS, Scholtz JE, Stehle A, Walter D, Zeuzem S, Wild PJ, Vogl TJ, Kinzler MN
Clin Oncol (R Coll Radiol) 2023 May;35(5):e312-e318. Epub 2023 Feb 1 doi: 10.1016/j.clon.2023.01.018. PMID: 36804153
Is nestin a diagnostic marker for combined hepatocellular-cholangiocarcinoma?
Sasaki M, Sato Y, Nakanuma Y
Histopathology 2022 Apr;80(5):859-868. Epub 2022 Mar 3 doi: 10.1111/his.14622. PMID: 35076959
Yttrium-90 Radioembolization for Unresectable Combined Hepatocellular-Cholangiocarcinoma.
Chan LS, Sze DY, Poultsides GA, Louie JD, Abdelrazek Mohammed MA, Wang DS
Cardiovasc Intervent Radiol 2017 Sep;40(9):1383-1391. Epub 2017 Apr 21 doi: 10.1007/s00270-017-1648-7. PMID: 28432387

Recent systematic reviews

Combined hepatocellular-cholangiocarcinoma: An update on epidemiology, classification, diagnosis and management.
Schizas D, Mastoraki A, Routsi E, Papapanou M, Tsapralis D, Vassiliu P, Toutouzas K, Felekouras E
Hepatobiliary Pancreat Dis Int 2020 Dec;19(6):515-523. Epub 2020 Jul 24 doi: 10.1016/j.hbpd.2020.07.004. PMID: 32753331
Pathological aspects of mucinous cholangiocarcinoma: A single-center experience and systematic review.
Laohawetwanit T, Klaikaew N
Pathol Int 2020 Sep;70(9):661-670. Epub 2020 Jul 7 doi: 10.1111/pin.12983. PMID: 32638458
Long-term outcomes of combined hepatocellular-cholangiocarcinoma after hepatectomy or liver transplantation: A systematic review and meta-analysis.
Li DB, Si XY, Wang SJ, Zhou YM
Hepatobiliary Pancreat Dis Int 2019 Feb;18(1):12-18. Epub 2018 Oct 25 doi: 10.1016/j.hbpd.2018.10.001. PMID: 30442549
A pooled analysis of combined liver and inferior vena cava resection for hepatic malignancy.
Zhou Y, Wu L, Xu D, Wan T, Si X
HPB (Oxford) 2017 Sep;19(9):768-774. Epub 2017 Jun 20 doi: 10.1016/j.hpb.2017.05.008. PMID: 28645571

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