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Age-related posterior subcapsular cataract

MedGen UID:
869099
•Concept ID:
C4023517
•
Finding
HPO: HP:0011144

Definition

A type of age-related cataract consisting of granular opacities occurring mainly in the central posterior cortex just under the posterior capsule. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAge-related posterior subcapsular cataract

Professional guidelines

PubMed

Adjunctive Intravitreal Anti-vascular Endothelial Growth Factor and Moxifloxacin Therapy in Management of Intraocular Tubercular Granulomas.
Agarwal M, Gupta C, Mohan KV, Upadhyay PK, Dhawan A, Jha V
Ocul Immunol Inflamm 2023 Jan;31(1):158-167. Epub 2021 Dec 17 doi: 10.1080/09273948.2021.2002367. PMID: 34919497
Intravitreal triamcinolone acetonide for treatment of intraocular oedematous and neovascular diseases.
Jonas JB
Acta Ophthalmol Scand 2005 Dec;83(6):645-63. doi: 10.1111/j.1600-0420.2005.00592.x. PMID: 16396641

Recent clinical studies

Etiology

Global and regional prevalence of age-related cataract: a comprehensive systematic review and meta-analysis.
Hashemi H, Pakzad R, Yekta A, Aghamirsalim M, Pakbin M, Ramin S, Khabazkhoob M
Eye (Lond) 2020 Aug;34(8):1357-1370. Epub 2020 Feb 13 doi: 10.1038/s41433-020-0806-3. PMID: 32055021Free PMC Article
Serum 25-hydroxyvitamin D and Age-Related Cataract.
Park S, Choi NK
Ophthalmic Epidemiol 2017 Oct;24(5):281-286. Epub 2017 Jun 28 doi: 10.1080/09286586.2017.1281427. PMID: 28657409
Myopia and age-related cataract: a systematic review and meta-analysis.
Pan CW, Cheng CY, Saw SM, Wang JJ, Wong TY
Am J Ophthalmol 2013 Nov;156(5):1021-1033.e1. Epub 2013 Aug 12 doi: 10.1016/j.ajo.2013.06.005. PMID: 23938120
The Lens Opacities Classification System III. The Longitudinal Study of Cataract Study Group.
Chylack LT Jr, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, Friend J, McCarthy D, Wu SY
Arch Ophthalmol 1993 Jun;111(6):831-6. doi: 10.1001/archopht.1993.01090060119035. PMID: 8512486
Daylight, diet, and age-related cataract.
West SK
Optom Vis Sci 1993 Nov;70(11):869-72. doi: 10.1097/00006324-199311000-00002. PMID: 8302521

Diagnosis

Age-related cataract - Prevalence, epidemiological pattern and emerging risk factors in a cross-sectional study from Central India.
Sarkar D, Sharma R, Singh P, Verma V, Karkhur S, Verma S, Soni D, Sharma B
Indian J Ophthalmol 2023 May;71(5):1905-1912. doi: 10.4103/ijo.IJO_2020_22. PMID: 37203054Free PMC Article
DeepLensNet: Deep Learning Automated Diagnosis and Quantitative Classification of Cataract Type and Severity.
Keenan TDL, Chen Q, Agrón E, Tham YC, Goh JHL, Lei X, Ng YP, Liu Y, Xu X, Cheng CY, Bikbov MM, Jonas JB, Bhandari S, Broadhead GK, Colyer MH, Corsini J, Cousineau-Krieger C, Gensheimer W, Grasic D, Lamba T, Magone MT, Maiberger M, Oshinsky A, Purt B, Shin SY, Thavikulwat AT, Lu Z, Chew EY; AREDS Deep Learning Research Group
Ophthalmology 2022 May;129(5):571-584. Epub 2022 Jan 3 doi: 10.1016/j.ophtha.2021.12.017. PMID: 34990643Free PMC Article
Etiology of posterior subcapsular cataracts based on a review of risk factors including aging, diabetes, and ionizing radiation.
Richardson RB, Ainsbury EA, Prescott CR, Lovicu FJ
Int J Radiat Biol 2020 Nov;96(11):1339-1361. Epub 2020 Sep 22 doi: 10.1080/09553002.2020.1812759. PMID: 32897800
Association Between Serum Complement C3 Levels and Age-Related Cataract.
Shao M, Li D, Teng J, Zhang Y, Li S, Cao W
Invest Ophthalmol Vis Sci 2017 Sep 1;58(11):4934-4939. doi: 10.1167/iovs.17-22522. PMID: 28973339
Serum 25-hydroxyvitamin D and Age-Related Cataract.
Park S, Choi NK
Ophthalmic Epidemiol 2017 Oct;24(5):281-286. Epub 2017 Jun 28 doi: 10.1080/09286586.2017.1281427. PMID: 28657409

Therapy

Evaluating the associations between obesity and age-related cataract: a Mendelian randomization study.
Tan AG, Kifley A, Flood VM, Holliday EG, Scott RJ, Cumming RG, Mitchell P, Wang JJ
Am J Clin Nutr 2019 Oct 1;110(4):969-976. doi: 10.1093/ajcn/nqz167. PMID: 31401654
Association of vitamin C with the risk of age-related cataract: a meta-analysis.
Wei L, Liang G, Cai C, Lv J
Acta Ophthalmol 2016 May;94(3):e170-6. Epub 2015 Mar 4 doi: 10.1111/aos.12688. PMID: 25735187
Ultraviolet light and ocular diseases.
Yam JC, Kwok AK
Int Ophthalmol 2014 Apr;34(2):383-400. Epub 2013 May 31 doi: 10.1007/s10792-013-9791-x. PMID: 23722672
Myopia and age-related cataract: a systematic review and meta-analysis.
Pan CW, Cheng CY, Saw SM, Wang JJ, Wong TY
Am J Ophthalmol 2013 Nov;156(5):1021-1033.e1. Epub 2013 Aug 12 doi: 10.1016/j.ajo.2013.06.005. PMID: 23938120
Daylight, diet, and age-related cataract.
West SK
Optom Vis Sci 1993 Nov;70(11):869-72. doi: 10.1097/00006324-199311000-00002. PMID: 8302521

Prognosis

Incidence, progression and risk factors of age-related cataract in Malays: The Singapore Malay Eye Study.
Tan AG, Tham YC, Chee ML, Mitchell P, Cumming RG, Sabanayagam C, Wong TY, Wang JJ, Cheng CY
Clin Exp Ophthalmol 2020 Jul;48(5):580-592. Epub 2020 May 4 doi: 10.1111/ceo.13757. PMID: 32255547
Wholegrain and legume consumption and the 5-year incidence of age-related cataract in the Blue Mountains Eye Study.
Tan AG, Flood VM, Kifley A, Russell J, Cumming RG, Mitchell P, Wang JJ
Br J Nutr 2020 Aug 14;124(3):306-315. Epub 2020 Mar 19 doi: 10.1017/S000711452000104X. PMID: 32189601
Serum selenium levels are associated with age-related cataract.
Post M, Lubiński W, Lubiński J, Krzystolik K, Baszuk P, Muszyńska M, Marciniak W
Ann Agric Environ Med 2018 Sep 25;25(3):443-448. Epub 2018 May 25 doi: 10.26444/aaem/90886. PMID: 30260193
Association Between Serum Complement C3 Levels and Age-Related Cataract.
Shao M, Li D, Teng J, Zhang Y, Li S, Cao W
Invest Ophthalmol Vis Sci 2017 Sep 1;58(11):4934-4939. doi: 10.1167/iovs.17-22522. PMID: 28973339
Myopia and age-related cataract: a systematic review and meta-analysis.
Pan CW, Cheng CY, Saw SM, Wang JJ, Wong TY
Am J Ophthalmol 2013 Nov;156(5):1021-1033.e1. Epub 2013 Aug 12 doi: 10.1016/j.ajo.2013.06.005. PMID: 23938120

Clinical prediction guides

Correlation between neutrophil-to-lymphocyte ratio and clinical manifestations and complications of retinitis pigmentosa.
He M, Wu T, Zhang L, Ye W, Ma J, Zhao C, Liu J, Zhou J
Acta Ophthalmol 2022 Feb;100(1):e278-e287. Epub 2021 Jun 2 doi: 10.1111/aos.14880. PMID: 34080305
Global and regional prevalence of age-related cataract: a comprehensive systematic review and meta-analysis.
Hashemi H, Pakzad R, Yekta A, Aghamirsalim M, Pakbin M, Ramin S, Khabazkhoob M
Eye (Lond) 2020 Aug;34(8):1357-1370. Epub 2020 Feb 13 doi: 10.1038/s41433-020-0806-3. PMID: 32055021Free PMC Article
Association Between Serum Complement C3 Levels and Age-Related Cataract.
Shao M, Li D, Teng J, Zhang Y, Li S, Cao W
Invest Ophthalmol Vis Sci 2017 Sep 1;58(11):4934-4939. doi: 10.1167/iovs.17-22522. PMID: 28973339
Frailty and age-related cataract.
Klein BE, Klein R, Knudtson MD
Ophthalmology 2006 Dec;113(12):2209-12. Epub 2006 Sep 25 doi: 10.1016/j.ophtha.2006.04.035. PMID: 16996595
The Lens Opacities Classification System III. The Longitudinal Study of Cataract Study Group.
Chylack LT Jr, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, Friend J, McCarthy D, Wu SY
Arch Ophthalmol 1993 Jun;111(6):831-6. doi: 10.1001/archopht.1993.01090060119035. PMID: 8512486

Recent systematic reviews

Body mass index influences age-related cataracts: an updated meta-analysis and systemic review.
Chen H, Sun X, Pei L, Wang T
Arq Bras Oftalmol 2024;87(4):e2021. Epub 2024 Apr 19 doi: 10.5935/0004-2749.2021-0382. PMID: 38656018
Cataract surgery in patients with retinitis pigmentosa: systematic review.
Khojasteh H, Riazi-Esfahani H, Mirghorbani M, Khalili Pour E, Mahmoudi A, Mahdizad Z, Akhavanrezayat A, Ghoraba H, Do DV, Nguyen QD
J Cataract Refract Surg 2023 Mar 1;49(3):312-320. Epub 2022 Nov 21 doi: 10.1097/j.jcrs.0000000000001101. PMID: 36730350Free PMC Article
Global and regional prevalence of age-related cataract: a comprehensive systematic review and meta-analysis.
Hashemi H, Pakzad R, Yekta A, Aghamirsalim M, Pakbin M, Ramin S, Khabazkhoob M
Eye (Lond) 2020 Aug;34(8):1357-1370. Epub 2020 Feb 13 doi: 10.1038/s41433-020-0806-3. PMID: 32055021Free PMC Article
Overweight, obesity, and age-related cataract: a meta-analysis.
Pan CW, Lin Y
Optom Vis Sci 2014 May;91(5):478-83. doi: 10.1097/OPX.0000000000000243. PMID: 24705485
Myopia and age-related cataract: a systematic review and meta-analysis.
Pan CW, Cheng CY, Saw SM, Wang JJ, Wong TY
Am J Ophthalmol 2013 Nov;156(5):1021-1033.e1. Epub 2013 Aug 12 doi: 10.1016/j.ajo.2013.06.005. PMID: 23938120

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