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Mixed germ cell tumor

MedGen UID:
87257
Concept ID:
C0334524
Neoplastic Process
Synonyms: Combined Germ Cell Neoplasm; combined germ cell neoplasm; Combined Germ Cell Tumor; combined germ cell tumor; combined germ cell tumour; mixed germ cell cancer; Mixed Germ Cell Neoplasm; mixed germ cell neoplasm; Mixed Germ Cell Tumor; mixed germ cell tumor; Mixed teratoma and seminoma; Mixed Teratoma and Seminoma
SNOMED CT: Mixed teratoma and seminoma (32844007); Mixed germ cell tumor (1156452003); Mixed germ cell tumor (32844007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0015864
Orphanet: ORPHA180234

Definition

A rare germ cell tumor characterized by composition of two or more malignant germ cell components, the most common combination being dysgerminoma and yolk sac tumor. The tumors typically occur between childhood and young adulthood. They are usually located in the gonads, occasionally also in other regions. Clinical presentation corresponds to the individual germ cell components and the tumor location; manifestations may include abdominal pain, abdominal mass, and menstrual disorder in females, and a testicular mass in males. The most important prognostic factor is tumor stage. [from ORDO]

Professional guidelines

PubMed

Liu P, Li W, Song HC, Jiao LL, Zhang WP, Sun N
J Pediatr Urol 2018 Oct;14(5):443.e1-443.e7. Epub 2018 Apr 3 doi: 10.1016/j.jpurol.2018.02.030. PMID: 29705139
Zhang R, Sun YC, Zhang GY, Wu LY, Zuo J
Eur J Gynaecol Oncol 2012;33(5):489-92. PMID: 23185794
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467

Recent clinical studies

Etiology

Cano Garcia C, Panunzio A, Tappero S, Piccinelli ML, Barletta F, Incesu RB, Law KW, Scheipner L, Tian Z, Saad F, Shariat SF, Tilki D, Briganti A, De Cobelli O, Terrone C, Antonelli A, Banek S, Kluth LA, Chun FKH, Karakiewicz PI
Medicina (Kaunas) 2023 Feb 24;59(3) doi: 10.3390/medicina59030451. PMID: 36984452Free PMC Article
Nasioudis D, Mastroyannis SA, Latif NA, Ko EM
Gynecol Oncol 2020 Apr;157(1):89-93. Epub 2020 Jan 31 doi: 10.1016/j.ygyno.2020.01.033. PMID: 32008791
Lee YL, Lai CR, Yen MS
J Ovarian Res 2019 Jan 10;12(1):2. doi: 10.1186/s13048-018-0476-y. PMID: 30630520Free PMC Article
Lin KY, Bryant S, Miller DS, Kehoe SM, Richardson DL, Lea JS
Gynecol Oncol 2014 Jul;134(1):84-9. Epub 2014 May 14 doi: 10.1016/j.ygyno.2014.05.003. PMID: 24836278
Ulbright TM
Am J Surg Pathol 1993 Nov;17(11):1075-91. doi: 10.1097/00000478-199311000-00001. PMID: 8214253

Diagnosis

Trpchevska EN, Todorovska B, Todorovska MB, Trajkovska M, Nikolova D, Dzambaz D, Deriban G, Licoska-Josifovikj F
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2023 Jul 1;44(2):47-52. Epub 2023 Jul 15 doi: 10.2478/prilozi-2023-0024. PMID: 37453124
Jung TY, Baek HJ, Kim SK, Lee KH
Childs Nerv Syst 2022 Jan;38(1):11-16. Epub 2021 Nov 9 doi: 10.1007/s00381-021-05393-4. PMID: 34755201
Compton ML, Lewis JS Jr, Faquin WC, Cipriani NA, Shi Q, Ely KA
Head Neck Pathol 2022 Mar;16(1):229-235. Epub 2021 Jun 9 doi: 10.1007/s12105-021-01343-3. PMID: 34106411Free PMC Article
Syu SH, Chang CL, Shih HJ
Int Braz J Urol 2019 May-Jun;45(3):629-633. doi: 10.1590/S1677-5538.IBJU.2018.0523. PMID: 30912892Free PMC Article
Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
Radiographics 2014 May-Jun;34(3):777-801. doi: 10.1148/rg.343130067. PMID: 24819795

Therapy

Trpchevska EN, Todorovska B, Todorovska MB, Trajkovska M, Nikolova D, Dzambaz D, Deriban G, Licoska-Josifovikj F
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2023 Jul 1;44(2):47-52. Epub 2023 Jul 15 doi: 10.2478/prilozi-2023-0024. PMID: 37453124
Demir T, Aliyev A, Seker M, Ersoz C, Coban G, Turk HM
J Coll Physicians Surg Pak 2021 Nov;31(11):1362-1365. doi: 10.29271/jcpsp.2021.11.1362. PMID: 34689500
Has Simsek D, Civan C, Ekenel M, Kuyumcu S, Sanli Y
Clin Nucl Med 2021 May 1;46(5):415-418. doi: 10.1097/RLU.0000000000003563. PMID: 33630811
Nitta M, Hoshi A, Higure T, Shimizu Y, Nakajima N, Hanai K, Kawamura Y, Terachi T
Tokai J Exp Clin Med 2016 Sep 20;41(3):147-51. PMID: 27628608
Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
Radiographics 2014 May-Jun;34(3):777-801. doi: 10.1148/rg.343130067. PMID: 24819795

Prognosis

Tabibi S, Kamanda S, Llosa N, Pratilas CA, Duncan BB, Esteves RS, Matoso A
Appl Immunohistochem Mol Morphol 2023 Jan 1;31(1):47-50. Epub 2022 Oct 26 doi: 10.1097/PAI.0000000000001081. PMID: 36476600Free PMC Article
Uda H, Uda T, Nakajo K, Tanoue Y, Okuno T, Koh S, Onishi Y, Ohata H, Watanabe Y, Umaba R, Kawashima T, Ohata K
World Neurosurg 2019 Dec;132:87-92. Epub 2019 Aug 27 doi: 10.1016/j.wneu.2019.08.079. PMID: 31470154
Lee YL, Lai CR, Yen MS
J Ovarian Res 2019 Jan 10;12(1):2. doi: 10.1186/s13048-018-0476-y. PMID: 30630520Free PMC Article
Nitta M, Hoshi A, Higure T, Shimizu Y, Nakajima N, Hanai K, Kawamura Y, Terachi T
Tokai J Exp Clin Med 2016 Sep 20;41(3):147-51. PMID: 27628608
Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
Radiographics 2014 May-Jun;34(3):777-801. doi: 10.1148/rg.343130067. PMID: 24819795

Clinical prediction guides

Trpchevska EN, Todorovska B, Todorovska MB, Trajkovska M, Nikolova D, Dzambaz D, Deriban G, Licoska-Josifovikj F
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2023 Jul 1;44(2):47-52. Epub 2023 Jul 15 doi: 10.2478/prilozi-2023-0024. PMID: 37453124
Sensu S, Keser SH, Gurbuz Y, Barisik NO, Gul AE
Arch Iran Med 2021 Apr 1;24(4):301-305. doi: 10.34172/aim.2021.42. PMID: 34196190
Nasioudis D, Mastroyannis SA, Latif NA, Ko EM
Gynecol Oncol 2020 Apr;157(1):89-93. Epub 2020 Jan 31 doi: 10.1016/j.ygyno.2020.01.033. PMID: 32008791
Lee YL, Lai CR, Yen MS
J Ovarian Res 2019 Jan 10;12(1):2. doi: 10.1186/s13048-018-0476-y. PMID: 30630520Free PMC Article
Cho DY, Wang YC, Ho WL
Childs Nerv Syst 1997 Jan;13(1):42-6. doi: 10.1007/s003810050038. PMID: 9083701

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