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Fibrillary astrocytoma

MedGen UID:
87270
•Concept ID:
C0334582
•
Neoplastic Process
Synonyms: Astrocytoma, Fibrillary; Fibrillary Astrocytoma; Fibrillary Astrocytomas
SNOMED CT: Fibrillary astrocytoma (71314006); Fibrous astrocytoma (71314006)
 
Monarch Initiative: MONDO:0016688
Orphanet: ORPHA251601

Definition

The most frequent histological variant of diffuse astrocytoma. It is predominantly composed of fibrillary neoplastic astrocytes. Nuclear atypia is a diagnostic criterion but mitotic activity, necrosis and microvascular proliferation are absent. The occasional or regional occurrence of gemistocytic neoplastic cells is compatible with the diagnosis of fibrillary astrocytoma. (WHO) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFibrillary astrocytoma
Follow this link to review classifications for Fibrillary astrocytoma in Orphanet.

Professional guidelines

PubMed

Treatment and Outcome in 65 Children with Optic Pathway Gliomas.
El Beltagy MA, Reda M, Enayet A, Zaghloul MS, Awad M, Zekri W, Taha H, El-Khateeb N
World Neurosurg 2016 May;89:525-34. Epub 2016 Feb 18 doi: 10.1016/j.wneu.2016.02.042. PMID: 26898488
Initial management of children with hypothalamic and thalamic tumors and the modifying role of neurofibromatosis-1.
Allen JC
Pediatr Neurosurg 2000 Mar;32(3):154-62. doi: 10.1159/000028922. PMID: 10867564
Spinal cord astrocytoma: pathological and treatment considerations.
Minehan KJ, Shaw EG, Scheithauer BW, Davis DL, Onofrio BM
J Neurosurg 1995 Oct;83(4):590-5. doi: 10.3171/jns.1995.83.4.0590. PMID: 7674006

Recent clinical studies

Etiology

1p/19q co-deleted fibrillary astrocytomas: Not everything that is co-deleted is an oligodendroglioma.
Andrews C, Prayson RA
Ann Diagn Pathol 2020 Jun;46:151519. Epub 2020 Apr 8 doi: 10.1016/j.anndiagpath.2020.151519. PMID: 32305004
Bilateral thalamic lesions.
Menon G, Nair S, Sudhir J, Rao BR, Krishnakumar K
Br J Neurosurg 2010 Oct;24(5):566-71. doi: 10.3109/02688691003777915. PMID: 20536292
A clinicopathologic reappraisal of brain stem tumor classification. Identification of pilocystic astrocytoma and fibrillary astrocytoma as distinct entities.
Fisher PG, Breiter SN, Carson BS, Wharam MD, Williams JA, Weingart JD, Foer DR, Goldthwaite PT, Tihan T, Burger PC
Cancer 2000 Oct 1;89(7):1569-76. doi: 10.1002/1097-0142(20001001)89:7<1569::aid-cncr22>3.0.co;2-0. PMID: 11013373
Initial management of children with hypothalamic and thalamic tumors and the modifying role of neurofibromatosis-1.
Allen JC
Pediatr Neurosurg 2000 Mar;32(3):154-62. doi: 10.1159/000028922. PMID: 10867564
The low-grade glioma debate: evidence defending the position of early radiation therapy.
Shaw EG
Clin Neurosurg 1995;42:488-94. PMID: 8846613

Diagnosis

1p/19q co-deleted fibrillary astrocytomas: Not everything that is co-deleted is an oligodendroglioma.
Andrews C, Prayson RA
Ann Diagn Pathol 2020 Jun;46:151519. Epub 2020 Apr 8 doi: 10.1016/j.anndiagpath.2020.151519. PMID: 32305004
IDH-1 polymorphisms in pilocytic astrocytomas.
Prayson RA
Ann Diagn Pathol 2019 Dec;43:151411. Epub 2019 Oct 23 doi: 10.1016/j.anndiagpath.2019.151411. PMID: 31677487
Mortality in children with low-grade glioma or glioneuronal tumors: A single-institution study.
Upadhyaya SA, Ghazwani Y, Wu S, Broniscer A, Boop FA, Gajjar A, Qaddoumi I
Pediatr Blood Cancer 2018 Jan;65(1) Epub 2017 Jul 14 doi: 10.1002/pbc.26717. PMID: 28708330Free PMC Article
Bilateral thalamic astrocytoma.
Habek M, Brinar VV, Mubrin Z, Barun B, Zarković K
J Neurooncol 2007 Sep;84(2):175-7. Epub 2007 May 24 doi: 10.1007/s11060-007-9404-5. PMID: 17522784
Initial management of children with hypothalamic and thalamic tumors and the modifying role of neurofibromatosis-1.
Allen JC
Pediatr Neurosurg 2000 Mar;32(3):154-62. doi: 10.1159/000028922. PMID: 10867564

Therapy

Treatment and Outcome in 65 Children with Optic Pathway Gliomas.
El Beltagy MA, Reda M, Enayet A, Zaghloul MS, Awad M, Zekri W, Taha H, El-Khateeb N
World Neurosurg 2016 May;89:525-34. Epub 2016 Feb 18 doi: 10.1016/j.wneu.2016.02.042. PMID: 26898488
A lower-dose, lower-toxicity cisplatin-etoposide regimen for childhood progressive low-grade glioma.
Massimino M, Spreafico F, Riva D, Biassoni V, Poggi G, Solero C, Gandola L, Genitori L, Modena P, Simonetti F, Potepan P, Casanova M, Meazza C, Clerici CA, Catania S, Sardi I, Giangaspero F
J Neurooncol 2010 Oct;100(1):65-71. Epub 2010 Feb 12 doi: 10.1007/s11060-010-0136-6. PMID: 20151174
Temozolomide in children with progressive low-grade glioma.
Gururangan S, Fisher MJ, Allen JC, Herndon JE 2nd, Quinn JA, Reardon DA, Vredenburgh JJ, Desjardins A, Phillips PC, Watral MA, Krauser JM, Friedman AH, Friedman HS
Neuro Oncol 2007 Apr;9(2):161-8. Epub 2007 Mar 8 doi: 10.1215/15228517-2006-030. PMID: 17347491Free PMC Article
Management of child optic pathway gliomas: new therapeutical option.
Suárez JC, Viano JC, Zunino S, Herrera EJ, Gomez J, Tramunt B, Marengo I, Hiramatzu E, Miras M, Pena M, Sonzini Astudillo B
Childs Nerv Syst 2006 Jul;22(7):679-84. Epub 2006 Jan 3 doi: 10.1007/s00381-005-0021-3. PMID: 16389565
Stereotactic radiosurgery for recurrent gliomas.
Chamberlain MC, Barba D, Kormanik P, Shea WM
Cancer 1994 Aug 15;74(4):1342-7. doi: 10.1002/1097-0142(19940815)74:4<1342::aid-cncr2820740426>3.0.co;2-y. PMID: 8055458

Prognosis

Mortality in children with low-grade glioma or glioneuronal tumors: A single-institution study.
Upadhyaya SA, Ghazwani Y, Wu S, Broniscer A, Boop FA, Gajjar A, Qaddoumi I
Pediatr Blood Cancer 2018 Jan;65(1) Epub 2017 Jul 14 doi: 10.1002/pbc.26717. PMID: 28708330Free PMC Article
Bilateral thalamic lesions.
Menon G, Nair S, Sudhir J, Rao BR, Krishnakumar K
Br J Neurosurg 2010 Oct;24(5):566-71. doi: 10.3109/02688691003777915. PMID: 20536292
Initial management of children with hypothalamic and thalamic tumors and the modifying role of neurofibromatosis-1.
Allen JC
Pediatr Neurosurg 2000 Mar;32(3):154-62. doi: 10.1159/000028922. PMID: 10867564
The low-grade glioma debate: evidence defending the position of early radiation therapy.
Shaw EG
Clin Neurosurg 1995;42:488-94. PMID: 8846613
Spinal cord astrocytoma: pathological and treatment considerations.
Minehan KJ, Shaw EG, Scheithauer BW, Davis DL, Onofrio BM
J Neurosurg 1995 Oct;83(4):590-5. doi: 10.3171/jns.1995.83.4.0590. PMID: 7674006

Clinical prediction guides

Can permanent cell lines originate from low-grade astrocytomas: overgrowth of "glia-like" cells in pilocytic and fibrillary (diffuse) astrocytoma cultures.
Sivakova I, Mraz P, Kubikova E, El Falougy H, Perzelova A
Bratisl Lek Listy 2021;122(6):367-370. doi: 10.4149/10.4149/BLL_2021_061. PMID: 34002608
The expression level of cannabinoid receptors type 1 and 2 in the different types of astrocytomas.
Hashemi M, Bashi S, Zali A
Mol Biol Rep 2020 Jul;47(7):5461-5467. Epub 2020 Jul 4 doi: 10.1007/s11033-020-05636-8. PMID: 32623617
1p/19q co-deleted fibrillary astrocytomas: Not everything that is co-deleted is an oligodendroglioma.
Andrews C, Prayson RA
Ann Diagn Pathol 2020 Jun;46:151519. Epub 2020 Apr 8 doi: 10.1016/j.anndiagpath.2020.151519. PMID: 32305004
The low-grade glioma debate: evidence defending the position of early radiation therapy.
Shaw EG
Clin Neurosurg 1995;42:488-94. PMID: 8846613
Pilocytic astrocytoma: correlation between the initial imaging features and clinical aggressiveness.
Strong JA, Hatten HP Jr, Brown MT, Debatin JF, Friedman HS, Oakes WJ, Tien R
AJR Am J Roentgenol 1993 Aug;161(2):369-72. doi: 10.2214/ajr.161.2.8333380. PMID: 8333380

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