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Diffuse astrocytoma

MedGen UID:
83708
Concept ID:
C0280785
Neoplastic Process
Synonyms: Fibrillary astrocytoma (histologic variant); Gemistocytic astrocytoma (histologic variant); Low-grade diffuse astrocytoma; Protoplasmic astrocytoma (histologic variant)
SNOMED CT: Diffuse astrocytoma (397381007)
 
Monarch Initiative: MONDO:0016686
Orphanet: ORPHA251595

Definition

A rare low-grade astrocytoma characterized by a high degree of cellular differentiation, slow growth, and diffuse infiltration of adjacent brain structures, and corresponding to WHO grade II. The tumor typically affects young adults and has an intrinsic tendency for progression to high-grade glioma. Histological variants are fibrillary, gemistocytic, and protoplasmic astrocytoma. Patients most commonly present with seizures, but also with other neurological or neuropsychological abnormalities, depending on the location. [from ORDO]

Professional guidelines

PubMed

Gokden M
Adv Anat Pathol 2017 Nov;24(6):379-391. doi: 10.1097/PAP.0000000000000170. PMID: 28885262
Ryall S, Tabori U, Hawkins C
Brain Tumor Pathol 2017 Apr;34(2):51-61. Epub 2017 Mar 25 doi: 10.1007/s10014-017-0282-z. PMID: 28342104
Ajlan A, Recht L
Semin Oncol 2014 Aug;41(4):446-457. Epub 2014 Jul 1 doi: 10.1053/j.seminoncol.2014.06.013. PMID: 25173138

Recent clinical studies

Etiology

Wu PB, Filley AC, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2. PMID: 37452934
Fabbri VP, Caporalini C, Asioli S, Buccoliero A
Pathologica 2022 Dec;114(6):410-421. doi: 10.32074/1591-951X-828. PMID: 36534420Free PMC Article
Martynov BV, Kholyavin AI, Nizkovolos VB, Parfenov VE, Trufanov GE, Svistov DV
Prog Neurol Surg 2018;32:27-38. Epub 2018 Jul 10 doi: 10.1159/000469677. PMID: 29990971
Shirahata M, Ono T, Stichel D, Schrimpf D, Reuss DE, Sahm F, Koelsche C, Wefers A, Reinhardt A, Huang K, Sievers P, Shimizu H, Nanjo H, Kobayashi Y, Miyake Y, Suzuki T, Adachi JI, Mishima K, Sasaki A, Nishikawa R, Bewerunge-Hudler M, Ryzhova M, Absalyamova O, Golanov A, Sinn P, Platten M, Jungk C, Winkler F, Wick A, Hänggi D, Unterberg A, Pfister SM, Jones DTW, van den Bent M, Hegi M, French P, Baumert BG, Stupp R, Gorlia T, Weller M, Capper D, Korshunov A, Herold-Mende C, Wick W, Louis DN, von Deimling A
Acta Neuropathol 2018 Jul;136(1):153-166. Epub 2018 Apr 23 doi: 10.1007/s00401-018-1849-4. PMID: 29687258
Gokden M
Adv Anat Pathol 2017 Nov;24(6):379-391. doi: 10.1097/PAP.0000000000000170. PMID: 28885262

Diagnosis

Wu PB, Filley AC, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2. PMID: 37452934
Thomas DL
Chin Clin Oncol 2023 Feb;12(1):7. doi: 10.21037/cco-22-120. PMID: 36922356
Hasselblatt M, Jaber M, Reuss D, Grauer O, Bibo A, Terwey S, Schick U, Ebel H, Niederstadt T, Stummer W, von Deimling A, Paulus W
J Neuropathol Exp Neurol 2018 Jun 1;77(6):422-425. doi: 10.1093/jnen/nly012. PMID: 29444314
Nagia L, Doyle JI, Hackney JR, Vaphiades MS, Kline LB, Levin MH
Surv Ophthalmol 2015 Nov-Dec;60(6):596-9. Epub 2015 Jun 14 doi: 10.1016/j.survophthal.2015.06.002. PMID: 26079932
Ohgaki H, Kleihues P
Clin Cancer Res 2013 Feb 15;19(4):764-72. Epub 2012 Dec 3 doi: 10.1158/1078-0432.CCR-12-3002. PMID: 23209033

Therapy

Ahrendsen JT, Torre M, Meredith DM, Hornick JL, Reardon DA, Wen PY, Yeo KK, Malinowski S, Ligon KL, Ramkissoon S, Alexandrescu S
Mod Pathol 2021 Jul;34(7):1236-1244. Epub 2021 Mar 26 doi: 10.1038/s41379-021-00795-w. PMID: 33772213
Martynov BV, Kholyavin AI, Nizkovolos VB, Parfenov VE, Trufanov GE, Svistov DV
Prog Neurol Surg 2018;32:27-38. Epub 2018 Jul 10 doi: 10.1159/000469677. PMID: 29990971
Ryall S, Tabori U, Hawkins C
Brain Tumor Pathol 2017 Apr;34(2):51-61. Epub 2017 Mar 25 doi: 10.1007/s10014-017-0282-z. PMID: 28342104
Ajlan A, Recht L
Semin Oncol 2014 Aug;41(4):446-457. Epub 2014 Jul 1 doi: 10.1053/j.seminoncol.2014.06.013. PMID: 25173138
Narita Y
Neurol Med Chir (Tokyo) 2013;53(7):429-37. doi: 10.2176/nmc.53.429. PMID: 23883553

Prognosis

Wu PB, Filley AC, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2. PMID: 37452934
Thomas DL
Chin Clin Oncol 2023 Feb;12(1):7. doi: 10.21037/cco-22-120. PMID: 36922356
Shirahata M, Ono T, Stichel D, Schrimpf D, Reuss DE, Sahm F, Koelsche C, Wefers A, Reinhardt A, Huang K, Sievers P, Shimizu H, Nanjo H, Kobayashi Y, Miyake Y, Suzuki T, Adachi JI, Mishima K, Sasaki A, Nishikawa R, Bewerunge-Hudler M, Ryzhova M, Absalyamova O, Golanov A, Sinn P, Platten M, Jungk C, Winkler F, Wick A, Hänggi D, Unterberg A, Pfister SM, Jones DTW, van den Bent M, Hegi M, French P, Baumert BG, Stupp R, Gorlia T, Weller M, Capper D, Korshunov A, Herold-Mende C, Wick W, Louis DN, von Deimling A
Acta Neuropathol 2018 Jul;136(1):153-166. Epub 2018 Apr 23 doi: 10.1007/s00401-018-1849-4. PMID: 29687258
Maharaj MM, Phan K, Xu J, Fairhall J, Reddy R, Rao PJV
J Clin Neurosci 2017 Sep;43:1-5. Epub 2017 May 20 doi: 10.1016/j.jocn.2017.04.043. PMID: 28539209
Ohgaki H, Kleihues P
Clin Cancer Res 2013 Feb 15;19(4):764-72. Epub 2012 Dec 3 doi: 10.1158/1078-0432.CCR-12-3002. PMID: 23209033

Clinical prediction guides

Rodrigues A, Zhang M, Toland A, Bhambhvani H, Hayden-Gephart M
World Neurosurg 2022 Feb;158:e903-e913. Epub 2021 Nov 27 doi: 10.1016/j.wneu.2021.11.089. PMID: 34844008
Onishi S, Amatya VJ, Kolakshyapati M, Takano M, Yonezawa U, Taguchi A, Kaichi Y, Takeshima Y, Awai K, Sugiyama K, Kurisu K, Yamasaki F
Eur J Radiol 2020 May;126:108924. Epub 2020 Mar 2 doi: 10.1016/j.ejrad.2020.108924. PMID: 32193035
Shirahata M, Ono T, Stichel D, Schrimpf D, Reuss DE, Sahm F, Koelsche C, Wefers A, Reinhardt A, Huang K, Sievers P, Shimizu H, Nanjo H, Kobayashi Y, Miyake Y, Suzuki T, Adachi JI, Mishima K, Sasaki A, Nishikawa R, Bewerunge-Hudler M, Ryzhova M, Absalyamova O, Golanov A, Sinn P, Platten M, Jungk C, Winkler F, Wick A, Hänggi D, Unterberg A, Pfister SM, Jones DTW, van den Bent M, Hegi M, French P, Baumert BG, Stupp R, Gorlia T, Weller M, Capper D, Korshunov A, Herold-Mende C, Wick W, Louis DN, von Deimling A
Acta Neuropathol 2018 Jul;136(1):153-166. Epub 2018 Apr 23 doi: 10.1007/s00401-018-1849-4. PMID: 29687258
Gokden M
Adv Anat Pathol 2017 Nov;24(6):379-391. doi: 10.1097/PAP.0000000000000170. PMID: 28885262
Marko NF, Weil RJ
Neurosurg Focus 2013 Feb;34(2):E1. doi: 10.3171/2012.12.FOCUS12283. PMID: 23373446

Recent systematic reviews

Nakasu S, Nakasu Y
Neurol Med Chir (Tokyo) 2022 Apr 15;62(4):177-185. Epub 2022 Feb 22 doi: 10.2176/jns-nmc.2021-0313. PMID: 35197400Free PMC Article
Andrews LJ, Thornton ZA, Saincher SS, Yao IY, Dawson S, McGuinness LA, Jones HE, Jefferies S, Short SC, Cheng HY, McAleenan A, Higgins JPT, Kurian KM
Neuro Oncol 2022 Apr 1;24(4):528-540. doi: 10.1093/neuonc/noab247. PMID: 34718782Free PMC Article
Ahmed SI, Bareeqa SB, Samar SS, Jilanee SDA
J Pak Med Assoc 2020 Dec;70(12(B)):2441-2448. doi: 10.47391/JPMA.581. PMID: 33475560

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