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Endometrial stromal tumor

MedGen UID:: 87280
•Concept ID:: C0334695
•: Neoplastic Process

Synonyms:	Endometrial Stromal Tumor; Endometrial Stromal Tumors; Stromal Tumor, Endometrial; Stromal Tumors, Endometrial; Tumor, Endometrial Stromal; Tumors, Endometrial Stromal
SNOMED CT:	Endometrial stromal tumor (446887007); Endometrial stromal tumor of uncertain behavior (68738004)

Monarch Initiative:	MONDO:0003311

Definition

Neoplasms of the endometrial stroma that sometimes involve the myometrium. These tumors contain cells that may closely or remotely resemble the normal stromal cells. Endometrial stromal neoplasms are divided into three categories: (1) benign stromal nodules; (2) low-grade stromal sarcoma, or endolymphatic stromal myosis; and (3) malignant endometrial stromal sarcoma (sarcoma, endometrial stromal). [from MONDO]

Professional guidelines

PubMed

Endometrial stromal tumors of the uterus: Epidemiology, pathological and biological features, treatment options and clinical outcomes.

Gadducci A, Multinu F, De Vitis LA, Cosio S, Carinelli S, Aletti GD
Gynecol Oncol 2023 Apr;171:95-105. Epub 2023 Feb 24 doi: 10.1016/j.ygyno.2023.02.009. PMID: 36842409

IFITM1, CD10, SMA, and h-caldesmon as a helpful combination in differential diagnosis between endometrial stromal tumor and cellular leiomyoma.

Zhao W, Cui M, Zhang R, Shen X, Xiong X, Ji X, Tao L, Jia W, Pang L, Sun Z, Wang C, Zou H
BMC Cancer 2021 Sep 23;21(1):1047. doi: 10.1186/s12885-021-08781-w. PMID: 34556086 Free PMC Article

See all (2)

Recent clinical studies

Etiology

Uterine Endometrial Stromal Tumors With Limited Infiltration: First Report of a Case Series Indicating Potential for Malignant Behavior.

Moore M, McCluggage WG
Int J Gynecol Pathol 2020 May;39(3):221-226. doi: 10.1097/PGP.0000000000000593. PMID: 30807369

Inflammatory Myofibroblastic Tumor in Female Genital Tract.

Shukla PS, Mittal K
Arch Pathol Lab Med 2019 Jan;143(1):122-129. Epub 2018 Jul 2 doi: 10.5858/arpa.2017-0575-RA. PMID: 29965784

Low-grade endometrial stromal sarcoma combined with leiomyoma (stromomyoma): A bizarre tumor of the uterus in a premenopausal woman.

Yenicesu O, Tokmak A, Sirvan AL, Danisman N, Güngör T
J Exp Ther Oncol 2018 Nov;12(4):281-286. PMID: 30476382

Cellular mesenchymal tumors of the uterus: a review emphasizing recent observations.

Oliva E
Int J Gynecol Pathol 2014 Jul;33(4):374-84. doi: 10.1097/PGP.0000000000000141. PMID: 24901397

Mesenchymal tumors of the uterine corpus with heterologous and hematopoietic components: a study of ten cases and review of the literature.

Kondi-Pafiti A, Grapsa D, Kairi-Vassilatou E, Kontogianni-Katsarou K, Koliopoulos C, Botsis D
Eur J Gynaecol Oncol 2006;27(1):73-7. PMID: 16550975

See all (10)

Diagnosis

Endometrial stromal tumors of the uterus: Epidemiology, pathological and biological features, treatment options and clinical outcomes.

Gadducci A, Multinu F, De Vitis LA, Cosio S, Carinelli S, Aletti GD
Gynecol Oncol 2023 Apr;171:95-105. Epub 2023 Feb 24 doi: 10.1016/j.ygyno.2023.02.009. PMID: 36842409

Endometrial stromal tumors: Diagnostic updates and challenges.

Niu S, Zheng W
Semin Diagn Pathol 2022 May;39(3):201-212. Epub 2022 Jan 14 doi: 10.1053/j.semdp.2022.01.004. PMID: 35067405

Inflammatory Myofibroblastic Tumor in Female Genital Tract.

Shukla PS, Mittal K
Arch Pathol Lab Med 2019 Jan;143(1):122-129. Epub 2018 Jul 2 doi: 10.5858/arpa.2017-0575-RA. PMID: 29965784

Endometrial stromal tumors: the new WHO classification.

Conklin CM, Longacre TA
Adv Anat Pathol 2014 Nov;21(6):383-93. doi: 10.1097/PAP.0000000000000046. PMID: 25299308

Cellular mesenchymal tumors of the uterus: a review emphasizing recent observations.

Oliva E
Int J Gynecol Pathol 2014 Jul;33(4):374-84. doi: 10.1097/PGP.0000000000000141. PMID: 24901397

See all (30)

Therapy

Hyperhaploid uterine mesenchymal tumors-a novel genetic subgroup?

Holzmann C, Löning T, Bullerdiek J
Cancer Genet 2016 Jun;209(6):278-81. Epub 2016 Mar 8 doi: 10.1016/j.cancergen.2016.02.005. PMID: 27397601

Uterine tumors resembling ovarian sex cord tumors, a clinicopathologic study of six cases.

Bakula-Zalewska E, Danska-Bidzinska A, Kowalewska M, Piascik A, Nasierowska-Guttmejer A, Bidzinski M
Ann Diagn Pathol 2014 Dec;18(6):329-32. Epub 2014 Aug 30 doi: 10.1016/j.anndiagpath.2014.08.009. PMID: 25257516

Tumor dissemination after laparoscopic surgery for an unsuspected endometrial stromal tumor.

Pavlakis K, Messini I, Papadimitriou CA, Zagouri F, Yiannou P, Mavrelos D, Panoskaltis T
Eur J Gynaecol Oncol 2011;32(3):362-3. PMID: 21797138

Myxoid endometrial stromal sarcoma of the uterus.

Kasashima S, Kobayashi M, Yamada M, Oda Y
Pathol Int 2003 Sep;53(9):637-41. doi: 10.1046/j.1440-1827.2003.01525.x. PMID: 14507323

Hormonal treatment of an endometrial stromal nodule followed by local excision.

Schilder JM, Hurd WW, Roth LM, Sutton GP
Obstet Gynecol 1999 May;93(5 Pt 2):805-7. doi: 10.1016/s0029-7844(98)00332-9. PMID: 10912400

See all (6)

Prognosis

Endometrial stromal tumors of the uterus: Epidemiology, pathological and biological features, treatment options and clinical outcomes.

Gadducci A, Multinu F, De Vitis LA, Cosio S, Carinelli S, Aletti GD
Gynecol Oncol 2023 Apr;171:95-105. Epub 2023 Feb 24 doi: 10.1016/j.ygyno.2023.02.009. PMID: 36842409

IFITM1, CD10, SMA, and h-caldesmon as a helpful combination in differential diagnosis between endometrial stromal tumor and cellular leiomyoma.

Zhao W, Cui M, Zhang R, Shen X, Xiong X, Ji X, Tao L, Jia W, Pang L, Sun Z, Wang C, Zou H
BMC Cancer 2021 Sep 23;21(1):1047. doi: 10.1186/s12885-021-08781-w. PMID: 34556086 Free PMC Article

Uterine sarcomas.

Ganjoo KN
Curr Probl Cancer 2019 Aug;43(4):283-288. Epub 2019 Jun 14 doi: 10.1016/j.currproblcancer.2019.06.001. PMID: 31235185

Endometrial stromal tumors: the new WHO classification.

Conklin CM, Longacre TA
Adv Anat Pathol 2014 Nov;21(6):383-93. doi: 10.1097/PAP.0000000000000046. PMID: 25299308

Malignant potential of endometrial stromal tumor with limited infiltration: a case report.

Su TF, Chao TK, Lee HS, Perng CL, Nieh S
Int J Surg Pathol 2014 Sep;22(6):559-63. Epub 2013 Oct 23 doi: 10.1177/1066896913506934. PMID: 24155223

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Clinical prediction guides

IFITM1, CD10, SMA, and h-caldesmon as a helpful combination in differential diagnosis between endometrial stromal tumor and cellular leiomyoma.

Zhao W, Cui M, Zhang R, Shen X, Xiong X, Ji X, Tao L, Jia W, Pang L, Sun Z, Wang C, Zou H
BMC Cancer 2021 Sep 23;21(1):1047. doi: 10.1186/s12885-021-08781-w. PMID: 34556086 Free PMC Article

Uterine lesions with sex cord-like architectures: a systematic review.

Jia M, Sun PL, Gao H
Diagn Pathol 2019 Nov 18;14(1):129. doi: 10.1186/s13000-019-0909-y. PMID: 31739799 Free PMC Article

Endometrial stromal tumors: the new WHO classification.

Conklin CM, Longacre TA
Adv Anat Pathol 2014 Nov;21(6):383-93. doi: 10.1097/PAP.0000000000000046. PMID: 25299308

Cellular mesenchymal tumors of the uterus: a review emphasizing recent observations.

Oliva E
Int J Gynecol Pathol 2014 Jul;33(4):374-84. doi: 10.1097/PGP.0000000000000141. PMID: 24901397

Uterine tumor resembling an ovarian sex-cord tumor: report of a case of an endometrial stromal tumor with foam cells and ultrastructural evidence of epithelial differentiation.

Fekete PS, Vellios F, Patterson BD
Int J Gynecol Pathol 1985;4(4):378-87. PMID: 4086162

See all (6)