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Abnormal proportion of class-switched memory B cells

MedGen UID:
892550
•Concept ID:
C4072924
•
Finding
Synonym: Abnormal class-switched memory B cell count
 
HPO: HP:0030386

Definition

A deviation of the normal proportion of class-switched memory B cells (CD19+/CD27+/IgM-/IgD-) in circulation relative to the total number of B cells. Marginal zone B cells undergo limited somatic hypermutation and produce high-affinity IgM and some IgG, whereas class-switched memory B cells synthetize IgG, IgM, and IgA. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal proportion of class-switched memory B cells

Recent clinical studies

Etiology

Favorable efficacy of rituximab in ANCA-associated vasculitis patients with excessive B cell differentiation.
Miyazaki Y, Nakayamada S, Kubo S, Ishikawa Y, Yoshikawa M, Sakata K, Iwata S, Miyagawa I, Nakano K, Tanaka Y
Arthritis Res Ther 2020 Jun 15;22(1):141. doi: 10.1186/s13075-020-02215-x. PMID: 32539843Free PMC Article
Peripheral Immunophenotyping Identifies Three Subgroups Based on T Cell Heterogeneity in Lupus Patients.
Kubo S, Nakayamada S, Yoshikawa M, Miyazaki Y, Sakata K, Nakano K, Hanami K, Iwata S, Miyagawa I, Saito K, Tanaka Y
Arthritis Rheumatol 2017 Oct;69(10):2029-2037. Epub 2017 Aug 25 doi: 10.1002/art.40180. PMID: 28605137
Recurrent respiratory infections, specific antibody deficiencies, and memory B cells.
Leiva LE, Monjure H, Sorensen RU
J Clin Immunol 2013 Jan;33 Suppl 1:S57-61. Epub 2012 Oct 24 doi: 10.1007/s10875-012-9814-9. PMID: 23093309

Diagnosis

Favorable efficacy of rituximab in ANCA-associated vasculitis patients with excessive B cell differentiation.
Miyazaki Y, Nakayamada S, Kubo S, Ishikawa Y, Yoshikawa M, Sakata K, Iwata S, Miyagawa I, Nakano K, Tanaka Y
Arthritis Res Ther 2020 Jun 15;22(1):141. doi: 10.1186/s13075-020-02215-x. PMID: 32539843Free PMC Article
Correlation of T follicular helper cells and plasmablasts with the development of organ involvement in patients with IgG4-related disease.
Kubo S, Nakayamada S, Zhao J, Yoshikawa M, Miyazaki Y, Nawata A, Hirata S, Nakano K, Saito K, Tanaka Y
Rheumatology (Oxford) 2018 Mar 1;57(3):514-524. doi: 10.1093/rheumatology/kex455. PMID: 29253269

Therapy

Favorable efficacy of rituximab in ANCA-associated vasculitis patients with excessive B cell differentiation.
Miyazaki Y, Nakayamada S, Kubo S, Ishikawa Y, Yoshikawa M, Sakata K, Iwata S, Miyagawa I, Nakano K, Tanaka Y
Arthritis Res Ther 2020 Jun 15;22(1):141. doi: 10.1186/s13075-020-02215-x. PMID: 32539843Free PMC Article

Prognosis

Recurrent respiratory infections, specific antibody deficiencies, and memory B cells.
Leiva LE, Monjure H, Sorensen RU
J Clin Immunol 2013 Jan;33 Suppl 1:S57-61. Epub 2012 Oct 24 doi: 10.1007/s10875-012-9814-9. PMID: 23093309

Clinical prediction guides

Favorable efficacy of rituximab in ANCA-associated vasculitis patients with excessive B cell differentiation.
Miyazaki Y, Nakayamada S, Kubo S, Ishikawa Y, Yoshikawa M, Sakata K, Iwata S, Miyagawa I, Nakano K, Tanaka Y
Arthritis Res Ther 2020 Jun 15;22(1):141. doi: 10.1186/s13075-020-02215-x. PMID: 32539843Free PMC Article
Peripheral Immunophenotyping Identifies Three Subgroups Based on T Cell Heterogeneity in Lupus Patients.
Kubo S, Nakayamada S, Yoshikawa M, Miyazaki Y, Sakata K, Nakano K, Hanami K, Iwata S, Miyagawa I, Saito K, Tanaka Y
Arthritis Rheumatol 2017 Oct;69(10):2029-2037. Epub 2017 Aug 25 doi: 10.1002/art.40180. PMID: 28605137

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