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Increased proportion of naive B cells

MedGen UID:
892667
Concept ID:
C4072910
Finding
Synonym: Increased naive B cell count
 
HPO: HP:0030371

Definition

An elevation above the normal proportion of naive B cells (CD19+/CD27-/IgD+/IgM+) relative to total number of B cells. Naive B cells represent one of the subtypes of B cells in the peripheral blood, and are B cells that have not been exposed to antigen. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased proportion of naive B cells

Professional guidelines

PubMed

Ruschil C, Gabernet G, Kemmerer CL, Jarboui MA, Klose F, Poli S, Ziemann U, Nahnsen S, Kowarik MC
Front Immunol 2023;14:1133967. Epub 2023 Mar 7 doi: 10.3389/fimmu.2023.1133967. PMID: 36960053Free PMC Article
Ruck T, Pfeuffer S, Schulte-Mecklenbeck A, Gross CC, Lindner M, Metze D, Ehrchen J, Sondermann W, Pul R, Kleinschnitz C, Wiendl H, Meuth SG, Klotz L
Neurology 2018 Dec 11;91(24):e2233-e2237. Epub 2018 Nov 7 doi: 10.1212/WNL.0000000000006648. PMID: 30404783Free PMC Article
Hersh CM, Cohen JA
Immunotherapy 2014;6(3):249-59. doi: 10.2217/imt.14.7. PMID: 24762071

Recent clinical studies

Etiology

Bae H, Lee H, Ko EJ, Kim CD, Lee SH, Yang CW, Oh EJ, Chung BH
HLA 2023 Sep;102(3):316-330. Epub 2023 Apr 10 doi: 10.1111/tan.15061. PMID: 37038287
Nakamura S, Ohuchida K, Ohtsubo Y, Yamada Y, Tsutsumi C, Okuda S, Hisano K, Mochida Y, Shinkawa T, Iwamoto C, Torata N, Mizuuchi Y, Shindo K, Nakata K, Moriyama T, Torisu T, Nagai E, Morisaki T, Kitazono T, Oda Y, Nakamura M
Clin Transl Med 2023 Jan;13(1):e1181. doi: 10.1002/ctm2.1181. PMID: 36650114Free PMC Article
Rae W, Sowerby JM, Verhoeven D, Youssef M, Kotagiri P, Savinykh N, Coomber EL, Boneparth A, Chan A, Gong C, Jansen MH, du Long R, Santilli G, Simeoni I, Stephens J, Wu K, Zinicola M, Allen HL, Baxendale H, Kumararatne D, Gkrania-Klotsas E, Scheffler Mendoza SC, Yamazaki-Nakashimada MA, Ruiz LB, Rojas-Maruri CM, Lugo Reyes SO, Lyons PA, Williams AP, Hodson DJ, Bishop GA, Thrasher AJ, Thomas DC, Murphy MP, Vyse TJ, Milner JD, Kuijpers TW, Smith KGC
Sci Immunol 2022 Aug 12;7(74):eabn3800. doi: 10.1126/sciimmunol.abn3800. PMID: 35960817
Forestier A, Guerrier T, Jouvray M, Giovannelli J, Lefèvre G, Sobanski V, Hauspie C, Hachulla E, Hatron PY, Zéphir H, Vermersch P, Labalette M, Launay D, Dubucquoi S
Autoimmun Rev 2018 Mar;17(3):244-255. Epub 2018 Jan 16 doi: 10.1016/j.autrev.2017.10.015. PMID: 29343447
Carvajal Alegria G, Gazeau P, Hillion S, Daïen CI, Cornec DYK
Clin Rev Allergy Immunol 2017 Oct;53(2):219-236. doi: 10.1007/s12016-017-8608-5. PMID: 28474288

Diagnosis

Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Peterson JN, Boackle SA, Taitano SH, Sang A, Lang J, Kelly M, Rahkola JT, Miranda AM, Sheridan RM, Thurman JM, Rao VK, Torres RM, Pelanda R
Front Immunol 2022;13:795209. Epub 2022 Feb 4 doi: 10.3389/fimmu.2022.795209. PMID: 35185888Free PMC Article
Yang Y, He W, Wang ZR, Wang YJ, Li LL, Lu JZ, Tao Y, Zhang J, Fu SJ, Wang ZP, Liu SH
Biomed Res Int 2021;2021:1930706. Epub 2021 Jan 9 doi: 10.1155/2021/1930706. PMID: 33575321Free PMC Article
Elmér E, Smargianaki S, Pettersson Å, Skattum L, Ohlsson S, Hellmark T, Johansson ÅCM
J Immunol Res 2020;2020:8209737. Epub 2020 Nov 28 doi: 10.1155/2020/8209737. PMID: 33313327Free PMC Article
Carvajal Alegria G, Gazeau P, Hillion S, Daïen CI, Cornec DYK
Clin Rev Allergy Immunol 2017 Oct;53(2):219-236. doi: 10.1007/s12016-017-8608-5. PMID: 28474288

Therapy

Visweswaran M, Hendrawan K, Massey JC, Khoo ML, Ford CD, Zaunders JJ, Withers B, Sutton IJ, Ma DDF, Moore JJ
Ann Clin Transl Neurol 2022 Feb;9(2):206-220. Epub 2022 Feb 1 doi: 10.1002/acn3.51510. PMID: 35106961Free PMC Article
Wang W, Liu L, Hui X, Wang Y, Ying W, Zhou Q, Hou J, Yang M, Sun B, Sun J, Wang X
BMC Immunol 2021 Mar 17;22(1):19. doi: 10.1186/s12865-021-00411-1. PMID: 33731004Free PMC Article
Fernández-Velasco JI, Kuhle J, Monreal E, Meca-Lallana V, Meca-Lallana J, Izquierdo G, Gascón-Giménez F, Sainz de la Maza S, Walo-Delgado PE, Maceski A, Rodríguez-Martín E, Roldán E, Villarrubia N, Saiz A, Blanco Y, Sánchez P, Carreón-Guarnizo E, Aladro Y, Brieva L, Íñiguez C, González-Suárez I, Rodríguez de Antonio LA, Masjuan J, Costa-Frossard L, Villar LM
Neurol Neuroimmunol Neuroinflamm 2021 Mar 4;8(2) Epub 2021 Jan 6 doi: 10.1212/NXI.0000000000000940. PMID: 33408167Free PMC Article
Ilander M, Olsson-Strömberg U, Schlums H, Guilhot J, Brück O, Lähteenmäki H, Kasanen T, Koskenvesa P, Söderlund S, Höglund M, Markevärn B, Själander A, Lotfi K, Dreimane A, Lübking A, Holm E, Björeman M, Lehmann S, Stenke L, Ohm L, Gedde-Dahl T, Majeed W, Ehrencrona H, Koskela S, Saussele S, Mahon FX, Porkka K, Hjorth-Hansen H, Bryceson YT, Richter J, Mustjoki S
Leukemia 2017 May;31(5):1108-1116. Epub 2016 Nov 28 doi: 10.1038/leu.2016.360. PMID: 27890936Free PMC Article
Hersh CM, Cohen JA
Immunotherapy 2014;6(3):249-59. doi: 10.2217/imt.14.7. PMID: 24762071

Prognosis

Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Nakamura S, Ohuchida K, Ohtsubo Y, Yamada Y, Tsutsumi C, Okuda S, Hisano K, Mochida Y, Shinkawa T, Iwamoto C, Torata N, Mizuuchi Y, Shindo K, Nakata K, Moriyama T, Torisu T, Nagai E, Morisaki T, Kitazono T, Oda Y, Nakamura M
Clin Transl Med 2023 Jan;13(1):e1181. doi: 10.1002/ctm2.1181. PMID: 36650114Free PMC Article
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
He Y, Luo J, Zhang G, Jin Y, Wang N, Lu J, Li C, Guo X, Qin N, Dai J, Chen Y
Hepatology 2022 Oct;76(4):1013-1029. Epub 2022 Mar 25 doi: 10.1002/hep.32444. PMID: 35243668Free PMC Article
Yang Y, He W, Wang ZR, Wang YJ, Li LL, Lu JZ, Tao Y, Zhang J, Fu SJ, Wang ZP, Liu SH
Biomed Res Int 2021;2021:1930706. Epub 2021 Jan 9 doi: 10.1155/2021/1930706. PMID: 33575321Free PMC Article

Clinical prediction guides

Kondo Y, Abe S, Toko H, Hirota T, Takahashi H, Shimizu M, Noma H, Tsuboi H, Matsumoto I, Inaba T, Sumida T
Sci Rep 2023 Jan 24;13(1):1304. doi: 10.1038/s41598-022-27153-3. PMID: 36693893Free PMC Article
Uçaryılmaz H, Ergün D, Vatansev H, Köksal H, Ural O, Arslan U, Artaç H
Turk J Med Sci 2022 Aug;52(4):888-898. Epub 2022 Aug 10 doi: 10.55730/1300-0144.5388. PMID: 36326397Free PMC Article
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
Bao W, Xie M, Ye Y
Cell Immunol 2022 Jul;377:104533. Epub 2022 May 6 doi: 10.1016/j.cellimm.2022.104533. PMID: 35594728
Peterson JN, Boackle SA, Taitano SH, Sang A, Lang J, Kelly M, Rahkola JT, Miranda AM, Sheridan RM, Thurman JM, Rao VK, Torres RM, Pelanda R
Front Immunol 2022;13:795209. Epub 2022 Feb 4 doi: 10.3389/fimmu.2022.795209. PMID: 35185888Free PMC Article

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