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Decreased proportion of transitional B cells

MedGen UID:
892796
•Concept ID:
C4072919
•
Finding
Synonym: Decreased transitional B cell count
 
HPO: HP:0030380

Definition

A reduction in the normal proportion of transitional B cells (CD19+/CD38high/IgMhigh) in circulation relative to the total number of B cells. B cells originate from precursors in the bone marrow, and the first cells which migrate to the peripheral blood have been classified as transitional B cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased proportion of transitional B cells

Recent clinical studies

Etiology

ARID5B regulates fatty acid metabolism and proliferation at the Pre-B cell stage during B cell development.
Chalise JP, Ehsani A, Lemecha M, Hung YW, Zhang G, Larson GP, Itakura K
Front Immunol 2023;14:1170475. Epub 2023 Jul 7 doi: 10.3389/fimmu.2023.1170475. PMID: 37483604Free PMC Article
Proportions of circulating transitional B cells associate with MRI activity in interferon beta-treated multiple sclerosis patients.
Mimpen M, Damoiseaux J, van Doorn W, Rolf L, Muris AH, Hupperts R, van Luijn MM, Gerlach O, Smolders J
J Neuroimmunol 2021 Sep 15;358:577664. Epub 2021 Jul 14 doi: 10.1016/j.jneuroim.2021.577664. PMID: 34280843
Decreased Circulating Transitional B-Cell to Memory B-Cell Ratio Is a Risk Factor for Relapse in Children with Steroid-Sensitive Nephrotic Syndrome.
Ling C, Chen Z, Fan J, Sun Q, Wang X, Hua L, Gui J, Liu X
Nephron 2021;145(2):107-112. Epub 2020 Dec 22 doi: 10.1159/000511319. PMID: 33352567
Identification of low-dose responsive metabolites in X-irradiated human B lymphoblastoid cells and fibroblasts.
Tsuyama N, Mizuno H, Katafuchi A, Abe Y, Kurosu Y, Yoshida M, Kamiya K, Sakai A
J Radiat Res 2015 Jan;56(1):46-58. Epub 2014 Sep 16 doi: 10.1093/jrr/rru078. PMID: 25227127Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Diagnosis

Integrating single-cell RNA sequencing with spatial transcriptomics reveals immune landscape for interstitial cystitis.
Peng L, Jin X, Li BY, Zeng X, Liao BH, Jin T, Chen JW, Gao XS, Wang W, He Q, Chen G, Gong LN, Shen H, Wang KJ, Li H, Luo DY
Signal Transduct Target Ther 2022 May 20;7(1):161. doi: 10.1038/s41392-022-00962-8. PMID: 35589692Free PMC Article
CD27(-)CD38(low)CD21(low) B-Cells Are Increased in Axial Spondyloarthritis.
Wilbrink R, Spoorenberg A, Arends S, van der Geest KSM, Brouwer E, Bootsma H, Kroese FGM, Verstappen GM
Front Immunol 2021;12:686273. Epub 2021 Jun 8 doi: 10.3389/fimmu.2021.686273. PMID: 34168654Free PMC Article
Decreased Circulating Transitional B-Cell to Memory B-Cell Ratio Is a Risk Factor for Relapse in Children with Steroid-Sensitive Nephrotic Syndrome.
Ling C, Chen Z, Fan J, Sun Q, Wang X, Hua L, Gui J, Liu X
Nephron 2021;145(2):107-112. Epub 2020 Dec 22 doi: 10.1159/000511319. PMID: 33352567
Increased Frequencies of Switched Memory B Cells and Plasmablasts in Peripheral Blood from Patients with ANCA-Associated Vasculitis.
Elmér E, Smargianaki S, Pettersson Å, Skattum L, Ohlsson S, Hellmark T, Johansson ÅCM
J Immunol Res 2020;2020:8209737. Epub 2020 Nov 28 doi: 10.1155/2020/8209737. PMID: 33313327Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Therapy

Early Increase of Circulating Transitional B Cells and Autoantibodies to Joint-Related Proteins in Patients With Metastatic Melanoma Developing Checkpoint Inhibitor-Induced Inflammatory Arthritis.
Gatto M, Bjursten S, Jonsson CA, Agelii ML, Jonell C, McGrath S, Lönnblom E, Sareila O, Holmdahl R, Rudin A, Levin M, Gjertsson I
Arthritis Rheumatol 2023 May;75(5):856-863. Epub 2023 Mar 14 doi: 10.1002/art.42406. PMID: 36409578
Proportions of circulating transitional B cells associate with MRI activity in interferon beta-treated multiple sclerosis patients.
Mimpen M, Damoiseaux J, van Doorn W, Rolf L, Muris AH, Hupperts R, van Luijn MM, Gerlach O, Smolders J
J Neuroimmunol 2021 Sep 15;358:577664. Epub 2021 Jul 14 doi: 10.1016/j.jneuroim.2021.577664. PMID: 34280843
Decreased Circulating Transitional B-Cell to Memory B-Cell Ratio Is a Risk Factor for Relapse in Children with Steroid-Sensitive Nephrotic Syndrome.
Ling C, Chen Z, Fan J, Sun Q, Wang X, Hua L, Gui J, Liu X
Nephron 2021;145(2):107-112. Epub 2020 Dec 22 doi: 10.1159/000511319. PMID: 33352567
Decrease of immature B cell and interleukin-10 during early-post-transplant period in renal transplant recipients under tacrolimus based immunosuppression.
Chung BH, Kim KW, Yu JH, Kim BM, Choi BS, Park CW, Kim YS, Cho ML, Yang CW
Transpl Immunol 2014 May;30(4):159-67. Epub 2014 Apr 5 doi: 10.1016/j.trim.2014.03.003. PMID: 24709525
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Prognosis

Long-Term Clinical Outcomes and B Cell Immune Reconstitution Following Allo-HCT With Prophylactic, Post-Transplant Rituximab.
Kennedy VE, Sahaf B, Wu F, Ehlinger ZJ, Arai S, Miklos DB
Transplant Cell Ther 2024 May;30(5):518.e1-518.e13. Epub 2024 Mar 6 doi: 10.1016/j.jtct.2024.02.025. PMID: 38458479
Proportions of circulating transitional B cells associate with MRI activity in interferon beta-treated multiple sclerosis patients.
Mimpen M, Damoiseaux J, van Doorn W, Rolf L, Muris AH, Hupperts R, van Luijn MM, Gerlach O, Smolders J
J Neuroimmunol 2021 Sep 15;358:577664. Epub 2021 Jul 14 doi: 10.1016/j.jneuroim.2021.577664. PMID: 34280843
Decreased Circulating Transitional B-Cell to Memory B-Cell Ratio Is a Risk Factor for Relapse in Children with Steroid-Sensitive Nephrotic Syndrome.
Ling C, Chen Z, Fan J, Sun Q, Wang X, Hua L, Gui J, Liu X
Nephron 2021;145(2):107-112. Epub 2020 Dec 22 doi: 10.1159/000511319. PMID: 33352567
Low-Grade Myelodysplastic Syndromes with Preserved CD34+ B-Cell Precursors (CD34+ Hematogones).
Chen Z, Ok CY, Wang W, Goswami M, Tang G, Routbort M, Jorgensen JL, Medeiros LJ, Wang SA
Cytometry B Clin Cytom 2020 Jan;98(1):36-42. Epub 2019 Jun 18 doi: 10.1002/cyto.b.21830. PMID: 31211490
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Clinical prediction guides

ARID5B regulates fatty acid metabolism and proliferation at the Pre-B cell stage during B cell development.
Chalise JP, Ehsani A, Lemecha M, Hung YW, Zhang G, Larson GP, Itakura K
Front Immunol 2023;14:1170475. Epub 2023 Jul 7 doi: 10.3389/fimmu.2023.1170475. PMID: 37483604Free PMC Article
Proportions of circulating transitional B cells associate with MRI activity in interferon beta-treated multiple sclerosis patients.
Mimpen M, Damoiseaux J, van Doorn W, Rolf L, Muris AH, Hupperts R, van Luijn MM, Gerlach O, Smolders J
J Neuroimmunol 2021 Sep 15;358:577664. Epub 2021 Jul 14 doi: 10.1016/j.jneuroim.2021.577664. PMID: 34280843
The immune cell landscape of peripheral blood mononuclear cells from PNS patients.
Ye Q, Zhou C, Li S, Wang J, Liu F, Liu Z, Mao J, Fu H
Sci Rep 2021 Jun 22;11(1):13083. doi: 10.1038/s41598-021-92573-6. PMID: 34158604Free PMC Article
Decreased Circulating Transitional B-Cell to Memory B-Cell Ratio Is a Risk Factor for Relapse in Children with Steroid-Sensitive Nephrotic Syndrome.
Ling C, Chen Z, Fan J, Sun Q, Wang X, Hua L, Gui J, Liu X
Nephron 2021;145(2):107-112. Epub 2020 Dec 22 doi: 10.1159/000511319. PMID: 33352567
Increased Frequencies of Switched Memory B Cells and Plasmablasts in Peripheral Blood from Patients with ANCA-Associated Vasculitis.
Elmér E, Smargianaki S, Pettersson Å, Skattum L, Ohlsson S, Hellmark T, Johansson ÅCM
J Immunol Res 2020;2020:8209737. Epub 2020 Nov 28 doi: 10.1155/2020/8209737. PMID: 33313327Free PMC Article

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