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Decreased proportion of naive B cells

MedGen UID:
892943
Concept ID:
C4072911
Finding
Synonym: Decreased naive B cell count
 
HPO: HP:0030372

Definition

A reduction below normal proportion of naive B cells (CD19+/CD27-/IgD+/IgM+) relative to total number of B cells. Naive B cells represent one of the subtypes of B cells in the peripheral blood, and are B cells that have not been exposed to antigen. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased proportion of naive B cells

Professional guidelines

PubMed

Hedman ÅK, Winter E, Yoosuf N, Benita Y, Berg L, Brynedal B, Folkersen L, Klareskog L, Maciejewski M, Sirota-Madi A, Spector Y, Ziemek D, Padyukov L, Shen-Orr SS, Jelinsky SA
Sci Rep 2023 Jun 21;13(1):10058. doi: 10.1038/s41598-023-36999-0. PMID: 37344505Free PMC Article
Ruschil C, Gabernet G, Kemmerer CL, Jarboui MA, Klose F, Poli S, Ziemann U, Nahnsen S, Kowarik MC
Front Immunol 2023;14:1133967. Epub 2023 Mar 7 doi: 10.3389/fimmu.2023.1133967. PMID: 36960053Free PMC Article
Sanges S, Germain N, Vignes S, Séguy D, Stabler S, Etienne N, Terriou L, Launay D, Hachulla É, Huglo D, Dubucquoi S, Labalette M, Lefèvre G
J Clin Immunol 2022 Oct;42(7):1461-1472. Epub 2022 Jun 23 doi: 10.1007/s10875-022-01299-1. PMID: 35737255

Recent clinical studies

Etiology

Zhu Y, Wang S, Yang Y, Shen B, Wang A, Zhang X, Zhang X, Li N, Gao Z, Liu Y, Zhu J, Wei Z, Guan J, Su K, Liu F, Gu M, Yin S
Front Immunol 2023;14:1186258. Epub 2023 May 22 doi: 10.3389/fimmu.2023.1186258. PMID: 37283767Free PMC Article
Bae H, Lee H, Ko EJ, Kim CD, Lee SH, Yang CW, Oh EJ, Chung BH
HLA 2023 Sep;102(3):316-330. Epub 2023 Apr 10 doi: 10.1111/tan.15061. PMID: 37038287
Nakamura S, Ohuchida K, Ohtsubo Y, Yamada Y, Tsutsumi C, Okuda S, Hisano K, Mochida Y, Shinkawa T, Iwamoto C, Torata N, Mizuuchi Y, Shindo K, Nakata K, Moriyama T, Torisu T, Nagai E, Morisaki T, Kitazono T, Oda Y, Nakamura M
Clin Transl Med 2023 Jan;13(1):e1181. doi: 10.1002/ctm2.1181. PMID: 36650114Free PMC Article
Forestier A, Guerrier T, Jouvray M, Giovannelli J, Lefèvre G, Sobanski V, Hauspie C, Hachulla E, Hatron PY, Zéphir H, Vermersch P, Labalette M, Launay D, Dubucquoi S
Autoimmun Rev 2018 Mar;17(3):244-255. Epub 2018 Jan 16 doi: 10.1016/j.autrev.2017.10.015. PMID: 29343447
Carvajal Alegria G, Gazeau P, Hillion S, Daïen CI, Cornec DYK
Clin Rev Allergy Immunol 2017 Oct;53(2):219-236. doi: 10.1007/s12016-017-8608-5. PMID: 28474288

Diagnosis

Sanges S, Germain N, Vignes S, Séguy D, Stabler S, Etienne N, Terriou L, Launay D, Hachulla É, Huglo D, Dubucquoi S, Labalette M, Lefèvre G
J Clin Immunol 2022 Oct;42(7):1461-1472. Epub 2022 Jun 23 doi: 10.1007/s10875-022-01299-1. PMID: 35737255
Gama A, Désy O, Béland S, Bouchard-Boivin F, Marcoux M, De Serres SA
Transpl Immunol 2022 Feb;70:101519. Epub 2021 Dec 24 doi: 10.1016/j.trim.2021.101519. PMID: 34958918
Yang Y, He W, Wang ZR, Wang YJ, Li LL, Lu JZ, Tao Y, Zhang J, Fu SJ, Wang ZP, Liu SH
Biomed Res Int 2021;2021:1930706. Epub 2021 Jan 9 doi: 10.1155/2021/1930706. PMID: 33575321Free PMC Article
Elmér E, Smargianaki S, Pettersson Å, Skattum L, Ohlsson S, Hellmark T, Johansson ÅCM
J Immunol Res 2020;2020:8209737. Epub 2020 Nov 28 doi: 10.1155/2020/8209737. PMID: 33313327Free PMC Article
Carvajal Alegria G, Gazeau P, Hillion S, Daïen CI, Cornec DYK
Clin Rev Allergy Immunol 2017 Oct;53(2):219-236. doi: 10.1007/s12016-017-8608-5. PMID: 28474288

Therapy

Uehara K, Tanoue K, Yamaguchi K, Ohmura H, Ito M, Matsushita Y, Tsuchihashi K, Tamura S, Shimokawa H, Isobe T, Shibata Y, Ariyama H, Tanaka R, Kusaba H, Yamamoto H, Oda Y, Akashi K, Baba E
Cancer Immunol Immunother 2023 Nov;72(11):3543-3558. Epub 2023 Aug 7 doi: 10.1007/s00262-023-03505-4. PMID: 37550428Free PMC Article
Kumar D, Nguyen TH, Bennett CM, Prince C, Lucas L, Park S, Lawrence T, Chappelle K, Ishaq M, Waller EK, Prahalad S, Briones M, Chandrakasan S
Blood 2023 Jan 19;141(3):238-243. doi: 10.1182/blood.2022015966. PMID: 36206504Free PMC Article
Visweswaran M, Hendrawan K, Massey JC, Khoo ML, Ford CD, Zaunders JJ, Withers B, Sutton IJ, Ma DDF, Moore JJ
Ann Clin Transl Neurol 2022 Feb;9(2):206-220. Epub 2022 Feb 1 doi: 10.1002/acn3.51510. PMID: 35106961Free PMC Article
Wang W, Liu L, Hui X, Wang Y, Ying W, Zhou Q, Hou J, Yang M, Sun B, Sun J, Wang X
BMC Immunol 2021 Mar 17;22(1):19. doi: 10.1186/s12865-021-00411-1. PMID: 33731004Free PMC Article
Fernández-Velasco JI, Kuhle J, Monreal E, Meca-Lallana V, Meca-Lallana J, Izquierdo G, Gascón-Giménez F, Sainz de la Maza S, Walo-Delgado PE, Maceski A, Rodríguez-Martín E, Roldán E, Villarrubia N, Saiz A, Blanco Y, Sánchez P, Carreón-Guarnizo E, Aladro Y, Brieva L, Íñiguez C, González-Suárez I, Rodríguez de Antonio LA, Masjuan J, Costa-Frossard L, Villar LM
Neurol Neuroimmunol Neuroinflamm 2021 Mar 4;8(2) Epub 2021 Jan 6 doi: 10.1212/NXI.0000000000000940. PMID: 33408167Free PMC Article

Prognosis

Nakamura S, Ohuchida K, Ohtsubo Y, Yamada Y, Tsutsumi C, Okuda S, Hisano K, Mochida Y, Shinkawa T, Iwamoto C, Torata N, Mizuuchi Y, Shindo K, Nakata K, Moriyama T, Torisu T, Nagai E, Morisaki T, Kitazono T, Oda Y, Nakamura M
Clin Transl Med 2023 Jan;13(1):e1181. doi: 10.1002/ctm2.1181. PMID: 36650114Free PMC Article
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
Visweswaran M, Hendrawan K, Massey JC, Khoo ML, Ford CD, Zaunders JJ, Withers B, Sutton IJ, Ma DDF, Moore JJ
Ann Clin Transl Neurol 2022 Feb;9(2):206-220. Epub 2022 Feb 1 doi: 10.1002/acn3.51510. PMID: 35106961Free PMC Article
Yang Y, He W, Wang ZR, Wang YJ, Li LL, Lu JZ, Tao Y, Zhang J, Fu SJ, Wang ZP, Liu SH
Biomed Res Int 2021;2021:1930706. Epub 2021 Jan 9 doi: 10.1155/2021/1930706. PMID: 33575321Free PMC Article
Carvajal Alegria G, Gazeau P, Hillion S, Daïen CI, Cornec DYK
Clin Rev Allergy Immunol 2017 Oct;53(2):219-236. doi: 10.1007/s12016-017-8608-5. PMID: 28474288

Clinical prediction guides

Kondo Y, Abe S, Toko H, Hirota T, Takahashi H, Shimizu M, Noma H, Tsuboi H, Matsumoto I, Inaba T, Sumida T
Sci Rep 2023 Jan 24;13(1):1304. doi: 10.1038/s41598-022-27153-3. PMID: 36693893Free PMC Article
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
Bao W, Xie M, Ye Y
Cell Immunol 2022 Jul;377:104533. Epub 2022 May 6 doi: 10.1016/j.cellimm.2022.104533. PMID: 35594728
Yu TS, Wang HY, Zhao YJ, Yu YF, Hou Y, Liu S, Han PP, Ni XF, Ji XB, Peng J, Liu XG, Hou M
Blood Adv 2021 Oct 26;5(20):4087-4101. doi: 10.1182/bloodadvances.2020003860. PMID: 34507351Free PMC Article
Forestier A, Guerrier T, Jouvray M, Giovannelli J, Lefèvre G, Sobanski V, Hauspie C, Hachulla E, Hatron PY, Zéphir H, Vermersch P, Labalette M, Launay D, Dubucquoi S
Autoimmun Rev 2018 Mar;17(3):244-255. Epub 2018 Jan 16 doi: 10.1016/j.autrev.2017.10.015. PMID: 29343447

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