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Increased proportion of immature B cells

MedGen UID:: 892989
•Concept ID:: C4072916
•: Finding

Synonym:	Increased immature B cell count

HPO:	HP:0030377

Definition

An elevation in the proportion above normal of immature B cells (CD19+/ CD21low) in circulation relative to total number of B cells. Immature B cells (IgM+) are still in final stages of development within the bone marrow. Naive B cells are those which have left the bone marrow, before they bind to the antigen for which they're specific (IgM+/IgD+). [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVIncreased proportion of immature B cells

Abnormal leukocyte morphology
- Abnormal leukocyte count
  - Abnormal lymphocyte count
    - Abnormal B cell count
      - Abnormal B cell subset distribution
        Abnormal proportion of immature B cells
        Increased proportion of immature B cells

Recent clinical studies

Etiology

ARID5B regulates fatty acid metabolism and proliferation at the Pre-B cell stage during B cell development.

Chalise JP, Ehsani A, Lemecha M, Hung YW, Zhang G, Larson GP, Itakura K
Front Immunol 2023;14:1170475. Epub 2023 Jul 7 doi: 10.3389/fimmu.2023.1170475. PMID: 37483604 Free PMC Article

Discovery of cellular and genetic signatures of immune tolerance in kidney transplant recipients through single cell RNA sequencing analysis.

Bae H, Lee H, Ko EJ, Kim CD, Lee SH, Yang CW, Oh EJ, Chung BH
HLA 2023 Sep;102(3):316-330. Epub 2023 Apr 10 doi: 10.1111/tan.15061. PMID: 37038287

Bortezomib and rituximab in de novo adolescent/adult CD20-positive, Ph-negative pre-B-cell acute lymphoblastic leukemia.

Jain H, Sengar M, Goli VB, Thorat J, Tembhare P, Shetty D, Bonda VNA, Nayak L, Subramanian PG, Bagal B, Patkar N, Sharma N, Gupta H, Gujral S
Blood Adv 2021 Sep 14;5(17):3436-3444. doi: 10.1182/bloodadvances.2020003368. PMID: 34461632 Free PMC Article

Belimumab alters transitional B-cell subset proportions in patients with stable systemic lupus erythematosus.

Benitez A, Torralba K, Ngo M, Salto LM, Choi KS, De Vera ME, Payne KJ
Lupus 2019 Oct;28(11):1337-1343. Epub 2019 Aug 18 doi: 10.1177/0961203319869468. PMID: 31423896 Free PMC Article

Identification of low-dose responsive metabolites in X-irradiated human B lymphoblastoid cells and fibroblasts.

Tsuyama N, Mizuno H, Katafuchi A, Abe Y, Kurosu Y, Yoshida M, Kamiya K, Sakai A
J Radiat Res 2015 Jan;56(1):46-58. Epub 2014 Sep 16 doi: 10.1093/jrr/rru078. PMID: 25227127 Free PMC Article

See all (14)

Diagnosis

Bortezomib and rituximab in de novo adolescent/adult CD20-positive, Ph-negative pre-B-cell acute lymphoblastic leukemia.

Increased Frequencies of Switched Memory B Cells and Plasmablasts in Peripheral Blood from Patients with ANCA-Associated Vasculitis.

Elmér E, Smargianaki S, Pettersson Å, Skattum L, Ohlsson S, Hellmark T, Johansson ÅCM
J Immunol Res 2020;2020:8209737. Epub 2020 Nov 28 doi: 10.1155/2020/8209737. PMID: 33313327 Free PMC Article

Identification of low-dose responsive metabolites in X-irradiated human B lymphoblastoid cells and fibroblasts.

Tsuyama N, Mizuno H, Katafuchi A, Abe Y, Kurosu Y, Yoshida M, Kamiya K, Sakai A
J Radiat Res 2015 Jan;56(1):46-58. Epub 2014 Sep 16 doi: 10.1093/jrr/rru078. PMID: 25227127 Free PMC Article

Immunohistochemical distinction of haematogones from B lymphoblastic leukaemia/lymphoma or B-cell acute lymphoblastic leukaemia (B-ALL) on bone marrow trephine biopsies: a study on 62 patients.

Al-Shieban S, Byrne E, Trivedi P, Morilla R, Matutes E, Naresh KN
Br J Haematol 2011 Aug;154(4):466-70. Epub 2011 Jul 2 doi: 10.1111/j.1365-2141.2011.08760.x. PMID: 21722099

Evolution of infectious mononucleosis into Epstein-Barr virus carrying monoclonal malignant lymphoma.

Abo W, Takada K, Kamada M, Imamura M, Motoya T, Iwanga M, Aya T, Yano S, Nakao T, Osato T
Lancet 1982 Jun 5;1(8284):1272-6. doi: 10.1016/s0140-6736(82)92842-2. PMID: 6123020

See all (5)

Therapy

Early Increase of Circulating Transitional B Cells and Autoantibodies to Joint-Related Proteins in Patients With Metastatic Melanoma Developing Checkpoint Inhibitor-Induced Inflammatory Arthritis.

Gatto M, Bjursten S, Jonsson CA, Agelii ML, Jonell C, McGrath S, Lönnblom E, Sareila O, Holmdahl R, Rudin A, Levin M, Gjertsson I
Arthritis Rheumatol 2023 May;75(5):856-863. Epub 2023 Mar 14 doi: 10.1002/art.42406. PMID: 36409578

Bortezomib and rituximab in de novo adolescent/adult CD20-positive, Ph-negative pre-B-cell acute lymphoblastic leukemia.

Fingolimod induces BAFF and expands circulating transitional B cells without activating memory B cells and plasma cells in multiple sclerosis.

Miyazaki Y, Niino M, Takahashi E, Suzuki M, Mizuno M, Hisahara S, Fukazawa T, Amino I, Nakano F, Nakamura M, Akimoto S, Minami N, Fujiki N, Doi S, Shimohama S, Terayama Y, Kikuchi S
Clin Immunol 2018 Feb;187:95-101. Epub 2017 Oct 25 doi: 10.1016/j.clim.2017.10.009. PMID: 29079163

See all (3)

Prognosis

B-cell maturation defects in common variable immunodeficiency and association with clinical features.

Berglund LJ, Wong SW, Fulcher DA
Pathology 2008 Apr;40(3):288-94. doi: 10.1080/00313020801911470. PMID: 18428049

See all (1)

Clinical prediction guides

ARID5B regulates fatty acid metabolism and proliferation at the Pre-B cell stage during B cell development.

Chalise JP, Ehsani A, Lemecha M, Hung YW, Zhang G, Larson GP, Itakura K
Front Immunol 2023;14:1170475. Epub 2023 Jul 7 doi: 10.3389/fimmu.2023.1170475. PMID: 37483604 Free PMC Article

Features of BAFF and APRIL receptors on circulating B cells in antineutrophil cytoplasmic antibody-associated vasculitis.

Shimojima Y, Kishida D, Ichikawa T, Takamatsu R, Nomura S, Sekijima Y
Clin Exp Immunol 2023 Jul 5;213(1):125-137. doi: 10.1093/cei/uxad024. PMID: 36794867 Free PMC Article

Increased Frequencies of Switched Memory B Cells and Plasmablasts in Peripheral Blood from Patients with ANCA-Associated Vasculitis.

Elmér E, Smargianaki S, Pettersson Å, Skattum L, Ohlsson S, Hellmark T, Johansson ÅCM
J Immunol Res 2020;2020:8209737. Epub 2020 Nov 28 doi: 10.1155/2020/8209737. PMID: 33313327 Free PMC Article

Belimumab alters transitional B-cell subset proportions in patients with stable systemic lupus erythematosus.

Benitez A, Torralba K, Ngo M, Salto LM, Choi KS, De Vera ME, Payne KJ
Lupus 2019 Oct;28(11):1337-1343. Epub 2019 Aug 18 doi: 10.1177/0961203319869468. PMID: 31423896 Free PMC Article

Altered distribution of peripheral blood memory B cells in humans chronically infected with Trypanosoma cruzi.

Fernández ER, Olivera GC, Quebrada Palacio LP, González MN, Hernandez-Vasquez Y, Sirena NM, Morán ML, Ledesma Patiño OS, Postan M
PLoS One 2014;9(8):e104951. Epub 2014 Aug 11 doi: 10.1371/journal.pone.0104951. PMID: 25111833 Free PMC Article

See all (14)

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Increased proportion of immature B cells

Definition

Term Hierarchy

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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