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Lymphoid hyperplasia

MedGen UID:
90735
•Concept ID:
C0333997
•
Disease or Syndrome
Synonym: Lymphoid Hyperplasia
SNOMED CT: Lymphoid hyperplasia (128863005); Lymphoid hyperplasia (43961000)
 
HPO: HP:0034839

Definition

An abnormal bone marrow finding characterized by many poorly circumscribed and occasionally confluent lymphoid nodules. The nodules contain small and uniform lymphocytes with rounded nuclei, clumped chromatin, and without prominent nucleoli. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLymphoid hyperplasia

Conditions with this feature

BENTA disease
MedGen UID:
1641265
•Concept ID:
C4551967
•
Disease or Syndrome
B-cell expansion with NFKB and T-cell anergy is an autosomal dominant disorder characterized by onset in infancy of splenomegaly and polyclonal expansion of B cells, resulting in peripheral lymphocytosis. Affected individuals also show mild immune dysfunction, including some defective antibody responses and T-cell anergy. There may be a predisposition to the development of B-cell malignancy (summary by Snow et al., 2012).
See: Condition Record
BENTA disease

Professional guidelines

PubMed

Thymic Hyperplasia Associated with Graves' Disease: Pathophysiology and Proposed Management Algorithm.
Haider U, Richards P, Gianoukakis AG
Thyroid 2017 Aug;27(8):994-1000. Epub 2017 Jul 7 doi: 10.1089/thy.2017.0086. PMID: 28578595
Primary Pulmonary Lymphoid Lesions: Radiologic and Pathologic Findings.
Sirajuddin A, Raparia K, Lewis VA, Franks TJ, Dhand S, Galvin JR, White CS
Radiographics 2016 Jan-Feb;36(1):53-70. doi: 10.1148/rg.2016140339. PMID: 26761531
Diagnosis and treatment of gastrointestinal disorders in patients with primary immunodeficiency.
Agarwal S, Mayer L
Clin Gastroenterol Hepatol 2013 Sep;11(9):1050-63. Epub 2013 Mar 13 doi: 10.1016/j.cgh.2013.02.024. PMID: 23501398Free PMC Article

Recent clinical studies

Etiology

Imaging findings of COPA Syndrome.
Nguyen HN, Salman R, Vogel TP, Silva-Carmona M, DeGuzman M, Guillerman RP
Pediatr Radiol 2023 May;53(5):844-853. Epub 2023 Feb 7 doi: 10.1007/s00247-023-05600-1. PMID: 36746811
Cutaneous reactive B-cell lymphoid proliferations.
Khalil S, Donthi D, Gru AA
J Cutan Pathol 2022 Oct;49(10):898-916. Epub 2022 Aug 4 doi: 10.1111/cup.14264. PMID: 35656820
Gastrointestinal lymphoproliferative lesions: a practical diagnostic approach.
Pizzi M, Sabattini E, Parente P, Bellan A, Doglioni C, Lazzi S
Pathologica 2020 Sep;112(3):227-247. doi: 10.32074/1591-951X-161. PMID: 33179624Free PMC Article
Appendicitis.
Humes D, Speake WJ, Simpson J
BMJ Clin Evid 2007 Jul 1;2007 PMID: 19454096Free PMC Article
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children.
Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, Berelowitz M, Dhillon AP, Thomson MA, Harvey P, Valentine A, Davies SE, Walker-Smith JA
Lancet 1998 Feb 28;351(9103):637-41. doi: 10.1016/s0140-6736(97)11096-0. PMID: 9500320

Diagnosis

Cutaneous reactive B-cell lymphoid proliferations.
Khalil S, Donthi D, Gru AA
J Cutan Pathol 2022 Oct;49(10):898-916. Epub 2022 Aug 4 doi: 10.1111/cup.14264. PMID: 35656820
Subcutaneous nodules following vaccination.
Collinson AC, Moore L, Cheung A, Gold MS, Goh DW
J Paediatr Child Health 2022 Mar;58(3):388-391. Epub 2022 Feb 9 doi: 10.1111/jpc.15900. PMID: 35137488
Pulmonary Nodular Lymphoid Hyperplasia.
Yell M, Rosado FG
Arch Pathol Lab Med 2019 Sep;143(9):1149-1153. Epub 2019 Feb 6 doi: 10.5858/arpa.2018-0188-RS. PMID: 30720334
Cutaneous Pseudolymphomas.
Romero-Pérez D, Blanes Martínez M, Encabo-Durán B
Actas Dermosifiliogr 2016 Oct;107(8):640-51. Epub 2016 Jun 8 doi: 10.1016/j.ad.2016.05.003. PMID: 27289134
Pulmonary pseudoneoplasms.
Yi E, Aubry MC
Arch Pathol Lab Med 2010 Mar;134(3):417-26. doi: 10.5858/134.3.417. PMID: 20196669

Therapy

Subcutaneous nodules following vaccination.
Collinson AC, Moore L, Cheung A, Gold MS, Goh DW
J Paediatr Child Health 2022 Mar;58(3):388-391. Epub 2022 Feb 9 doi: 10.1111/jpc.15900. PMID: 35137488
Cutaneous Pseudolymphomas.
Romero-Pérez D, Blanes Martínez M, Encabo-Durán B
Actas Dermosifiliogr 2016 Oct;107(8):640-51. Epub 2016 Jun 8 doi: 10.1016/j.ad.2016.05.003. PMID: 27289134
Lymphoproliferative Disease of the Orbit.
Li EY, Yuen HK, Cheuk W
Asia Pac J Ophthalmol (Phila) 2015 Mar-Apr;4(2):106-11. doi: 10.1097/APO.0000000000000102. PMID: 26065355
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children.
Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, Berelowitz M, Dhillon AP, Thomson MA, Harvey P, Valentine A, Davies SE, Walker-Smith JA
Lancet 1998 Feb 28;351(9103):637-41. doi: 10.1016/s0140-6736(97)11096-0. PMID: 9500320
Current perspectives on giardiasis.
Fisher CH, Oh KS, Bayless TM, Siegelman SS
Am J Roentgenol Radium Ther Nucl Med 1975 Sep;125(1):207-17. doi: 10.2214/ajr.125.1.207. PMID: 1106221

Prognosis

Primary Cutaneous Follicle Center Lymphoma.
Skala SL, Hristov B, Hristov AC
Arch Pathol Lab Med 2018 Nov;142(11):1313-1321. doi: 10.5858/arpa.2018-0215-RA. PMID: 30407851
Lymphoproliferative Disorders of the Lung.
Borie R, Wislez M, Antoine M, Cadranel J
Respiration 2017;94(2):157-175. Epub 2017 Jun 14 doi: 10.1159/000477740. PMID: 28609772
Lymphoproliferative Tumors of the Ocular Adnexa.
Verdijk RM
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):132-142. doi: 10.22608/APO.2016209. PMID: 28399341
Cutaneous Pseudolymphomas.
Romero-Pérez D, Blanes Martínez M, Encabo-Durán B
Actas Dermosifiliogr 2016 Oct;107(8):640-51. Epub 2016 Jun 8 doi: 10.1016/j.ad.2016.05.003. PMID: 27289134
Cutaneous lymphoid hyperplasias.
Gilliam AC, Wood GS
Semin Cutan Med Surg 2000 Jun;19(2):133-41. doi: 10.1016/s1085-5629(00)80011-5. PMID: 10892716

Clinical prediction guides

Cutaneous reactive B-cell lymphoid proliferations.
Khalil S, Donthi D, Gru AA
J Cutan Pathol 2022 Oct;49(10):898-916. Epub 2022 Aug 4 doi: 10.1111/cup.14264. PMID: 35656820
Subcutaneous nodules following vaccination.
Collinson AC, Moore L, Cheung A, Gold MS, Goh DW
J Paediatr Child Health 2022 Mar;58(3):388-391. Epub 2022 Feb 9 doi: 10.1111/jpc.15900. PMID: 35137488
Appendicitis.
Humes D, Speake WJ, Simpson J
BMJ Clin Evid 2007 Jul 1;2007 PMID: 19454096Free PMC Article
Microscopic thymoma.
Chalabreysse L, Orsini A, Vial C, Tronc F
Interact Cardiovasc Thorac Surg 2007 Feb;6(1):133-5. Epub 2006 Nov 13 doi: 10.1510/icvts.2006.137414. PMID: 17669792
Cutaneous lymphoid hyperplasias.
Gilliam AC, Wood GS
Semin Cutan Med Surg 2000 Jun;19(2):133-41. doi: 10.1016/s1085-5629(00)80011-5. PMID: 10892716

Recent systematic reviews

Intralesional biologics for inflammatory dermatoses: A systematic review.
Seivright JR, Villa NM, De DR, Hsiao JL, Shi VY
Dermatol Ther 2022 Feb;35(2):e15234. Epub 2021 Dec 8 doi: 10.1111/dth.15234. PMID: 34825744
Crohn's-like Enteritis in X-Linked Agammaglobulinemia: A Case Series and Systematic Review.
Khan F, Person H, Dekio F, Ogawa M, Ho HE, Dunkin D, Secord E, Cunningham-Rundles C, Ward SC
J Allergy Clin Immunol Pract 2021 Sep;9(9):3466-3478. Epub 2021 May 21 doi: 10.1016/j.jaip.2021.04.070. PMID: 34029777Free PMC Article
Pediatric cellular neurothekeoma: Seven cases and systematic review of the literature.
Murphrey M, Huy Nguyen A, White KP, Krol A, Bernert R, Yarbrough K
Pediatr Dermatol 2020 Mar;37(2):320-325. Epub 2020 Jan 12 doi: 10.1111/pde.14043. PMID: 31930561
Association between unilateral tonsillar enlargement and lymphoma in children: A systematic review and meta-analysis.
Guimarães AC, de Carvalho GM, Correa CR, Gusmão RJ
Crit Rev Oncol Hematol 2015 Mar;93(3):304-11. Epub 2014 Nov 22 doi: 10.1016/j.critrevonc.2014.11.003. PMID: 25487766
Appendicitis.
Humes D, Speake WJ, Simpson J
BMJ Clin Evid 2007 Jul 1;2007 PMID: 19454096Free PMC Article

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