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Diffuse Astrocytoma, IDH-Wildtype

MedGen UID:
927223
•Concept ID:
C4289691
•
Neoplastic Process

Definition

Diffuse astrocytoma lacking mutations in IDH1 or IDH2 genes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffuse Astrocytoma, IDH-Wildtype

Professional guidelines

PubMed

An update on the molecular biology of glioblastoma, with clinical implications and progress in its treatment.
Verdugo E, Puerto I, Medina MÁ
Cancer Commun (Lond) 2022 Nov;42(11):1083-1111. Epub 2022 Sep 21 doi: 10.1002/cac2.12361. PMID: 36129048Free PMC Article
Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline.
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238
cIMPACT-NOW update 3: recommended diagnostic criteria for "Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV".
Brat DJ, Aldape K, Colman H, Holland EC, Louis DN, Jenkins RB, Kleinschmidt-DeMasters BK, Perry A, Reifenberger G, Stupp R, von Deimling A, Weller M
Acta Neuropathol 2018 Nov;136(5):805-810. Epub 2018 Sep 26 doi: 10.1007/s00401-018-1913-0. PMID: 30259105Free PMC Article

Recent clinical studies

Etiology

The Diagnostic Value of Conventional MRI and CT Features in the Identification of the IDH1-Mutant and 1p/19q Co-Deletion in WHO Grade II Gliomas.
Zhao K, Sun G, Wang Q, Xue Z, Liu G, Xia Y, Yao A, Zhao Y, You N, Yang C, Xu B
Acad Radiol 2021 Jul;28(7):e189-e198. Epub 2020 Apr 28 doi: 10.1016/j.acra.2020.03.008. PMID: 32359929
Extent of resection and molecular pathologic subtype are potent prognostic factors of adult WHO grade II glioma.
Choi J, Kim SH, Ahn SS, Choi HJ, Yoon HI, Cho JH, Roh TH, Kang SG, Chang JH, Suh CO
Sci Rep 2020 Feb 7;10(1):2086. doi: 10.1038/s41598-020-59089-x. PMID: 32034238Free PMC Article
Clinical relevance of molecular subgrouping of gliomatosis cerebri per 2016 WHO classification: a clinicopathological study of 89 cases.
Kwon MJ, Kang SY, Cho H, Lee JI, Kim ST, Suh YL
Brain Pathol 2020 Mar;30(2):235-245. Epub 2019 Oct 7 doi: 10.1111/bpa.12782. PMID: 31435963Free PMC Article
Molecular features and clinical outcomes in surgically treated low-grade diffuse gliomas in patients over the age of 60.
Morshed RA, Han SJ, Hervey-Jumper SL, Pekmezci M, Troncon I, Chang SM, Butowski NA, Berger MS
J Neurooncol 2019 Jan;141(2):383-391. Epub 2018 Nov 29 doi: 10.1007/s11060-018-03044-4. PMID: 30498891
Clinical significance of the 2016 WHO classification in Japanese patients with gliomas.
Iuchi T, Sugiyama T, Ohira M, Kageyama H, Yokoi S, Sakaida T, Hasegawa Y, Setoguchi T, Itami M
Brain Tumor Pathol 2018 Apr;35(2):71-80. Epub 2018 Feb 22 doi: 10.1007/s10014-018-0309-0. PMID: 29470683

Diagnosis

The Diagnostic Value of Conventional MRI and CT Features in the Identification of the IDH1-Mutant and 1p/19q Co-Deletion in WHO Grade II Gliomas.
Zhao K, Sun G, Wang Q, Xue Z, Liu G, Xia Y, Yao A, Zhao Y, You N, Yang C, Xu B
Acad Radiol 2021 Jul;28(7):e189-e198. Epub 2020 Apr 28 doi: 10.1016/j.acra.2020.03.008. PMID: 32359929
Extent of resection and molecular pathologic subtype are potent prognostic factors of adult WHO grade II glioma.
Choi J, Kim SH, Ahn SS, Choi HJ, Yoon HI, Cho JH, Roh TH, Kang SG, Chang JH, Suh CO
Sci Rep 2020 Feb 7;10(1):2086. doi: 10.1038/s41598-020-59089-x. PMID: 32034238Free PMC Article
Molecular features and clinical outcomes in surgically treated low-grade diffuse gliomas in patients over the age of 60.
Morshed RA, Han SJ, Hervey-Jumper SL, Pekmezci M, Troncon I, Chang SM, Butowski NA, Berger MS
J Neurooncol 2019 Jan;141(2):383-391. Epub 2018 Nov 29 doi: 10.1007/s11060-018-03044-4. PMID: 30498891
Clinical significance of the 2016 WHO classification in Japanese patients with gliomas.
Iuchi T, Sugiyama T, Ohira M, Kageyama H, Yokoi S, Sakaida T, Hasegawa Y, Setoguchi T, Itami M
Brain Tumor Pathol 2018 Apr;35(2):71-80. Epub 2018 Feb 22 doi: 10.1007/s10014-018-0309-0. PMID: 29470683
Diffuse Astrocytoma, IDH-Wildtype: A Dissolving Diagnosis.
Hasselblatt M, Jaber M, Reuss D, Grauer O, Bibo A, Terwey S, Schick U, Ebel H, Niederstadt T, Stummer W, von Deimling A, Paulus W
J Neuropathol Exp Neurol 2018 Jun 1;77(6):422-425. doi: 10.1093/jnen/nly012. PMID: 29444314

Prognosis

The Diagnostic Value of Conventional MRI and CT Features in the Identification of the IDH1-Mutant and 1p/19q Co-Deletion in WHO Grade II Gliomas.
Zhao K, Sun G, Wang Q, Xue Z, Liu G, Xia Y, Yao A, Zhao Y, You N, Yang C, Xu B
Acad Radiol 2021 Jul;28(7):e189-e198. Epub 2020 Apr 28 doi: 10.1016/j.acra.2020.03.008. PMID: 32359929
Extent of resection and molecular pathologic subtype are potent prognostic factors of adult WHO grade II glioma.
Choi J, Kim SH, Ahn SS, Choi HJ, Yoon HI, Cho JH, Roh TH, Kang SG, Chang JH, Suh CO
Sci Rep 2020 Feb 7;10(1):2086. doi: 10.1038/s41598-020-59089-x. PMID: 32034238Free PMC Article
Clinical relevance of molecular subgrouping of gliomatosis cerebri per 2016 WHO classification: a clinicopathological study of 89 cases.
Kwon MJ, Kang SY, Cho H, Lee JI, Kim ST, Suh YL
Brain Pathol 2020 Mar;30(2):235-245. Epub 2019 Oct 7 doi: 10.1111/bpa.12782. PMID: 31435963Free PMC Article
Molecular features and clinical outcomes in surgically treated low-grade diffuse gliomas in patients over the age of 60.
Morshed RA, Han SJ, Hervey-Jumper SL, Pekmezci M, Troncon I, Chang SM, Butowski NA, Berger MS
J Neurooncol 2019 Jan;141(2):383-391. Epub 2018 Nov 29 doi: 10.1007/s11060-018-03044-4. PMID: 30498891
Clinical significance of the 2016 WHO classification in Japanese patients with gliomas.
Iuchi T, Sugiyama T, Ohira M, Kageyama H, Yokoi S, Sakaida T, Hasegawa Y, Setoguchi T, Itami M
Brain Tumor Pathol 2018 Apr;35(2):71-80. Epub 2018 Feb 22 doi: 10.1007/s10014-018-0309-0. PMID: 29470683

Clinical prediction guides

The Diagnostic Value of Conventional MRI and CT Features in the Identification of the IDH1-Mutant and 1p/19q Co-Deletion in WHO Grade II Gliomas.
Zhao K, Sun G, Wang Q, Xue Z, Liu G, Xia Y, Yao A, Zhao Y, You N, Yang C, Xu B
Acad Radiol 2021 Jul;28(7):e189-e198. Epub 2020 Apr 28 doi: 10.1016/j.acra.2020.03.008. PMID: 32359929
Extent of resection and molecular pathologic subtype are potent prognostic factors of adult WHO grade II glioma.
Choi J, Kim SH, Ahn SS, Choi HJ, Yoon HI, Cho JH, Roh TH, Kang SG, Chang JH, Suh CO
Sci Rep 2020 Feb 7;10(1):2086. doi: 10.1038/s41598-020-59089-x. PMID: 32034238Free PMC Article
Clinical relevance of molecular subgrouping of gliomatosis cerebri per 2016 WHO classification: a clinicopathological study of 89 cases.
Kwon MJ, Kang SY, Cho H, Lee JI, Kim ST, Suh YL
Brain Pathol 2020 Mar;30(2):235-245. Epub 2019 Oct 7 doi: 10.1111/bpa.12782. PMID: 31435963Free PMC Article

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