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Adap1 ArfGAP with dual PH domains 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171097, updated on 3-Apr-2024

Summary

Official Symbol
Adap1provided by RGD
Official Full Name
ArfGAP with dual PH domains 1provided by RGD
Primary source
RGD:621418
See related
Ensembl:ENSRNOG00000054033 AllianceGenome:RGD:621418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Centa1; p42IP4
Summary
Enables phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in regulation of GTPase activity. Predicted to be located in cytosol; nucleus; and plasma membrane. Orthologous to human ADAP1 (ArfGAP with dual PH domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 207.2), Kidney (RPKM 46.3) and 4 other tissues See more
Orthologs
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Genomic context

Location:
12q11
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (20438091..20489961)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (15323913..15376110)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (17416327..17468212)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily w, polypeptide 1 Neighboring gene cytochrome c oxidase assembly factor COX19 Neighboring gene guided entry of tail-anchored proteins factor 4 Neighboring gene Sad1 and UNC84 domain containing 1 Neighboring gene uncharacterized LOC102547493

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables inositol 1,3,4,5 tetrakisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol bisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
arf-GAP with dual PH domain-containing protein 1
Names
centaurin, alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133567.2NP_598251.1  arf-GAP with dual PH domain-containing protein 1

    See identical proteins and their annotated locations for NP_598251.1

    Status: VALIDATED

    Source sequence(s)
    BC099775
    UniProtKB/TrEMBL
    O88768, Q9QUI9
    Related
    ENSRNOP00000075236.1, ENSRNOT00000089590.2
    Conserved Domains (3) summary
    cd01251
    Location:252357
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:130238
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    cd08843
    Location:4113
    ArfGap_ADAP1; ADAP1 GTPase activating protein for Arf, with dual PH domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    20438091..20489961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598251.3XP_017453740.3  arf-GAP with dual PH domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRW6