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HIPK1 homeodomain interacting protein kinase 1 [ Homo sapiens (human) ]

Gene ID: 204851, updated on 3-Apr-2024

Summary

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Official Symbol
HIPK1provided by HGNC
Official Full Name
homeodomain interacting protein kinase 1provided by HGNC
Primary source
HGNC:HGNC:19006
See related
Ensembl:ENSG00000163349 MIM:608003; AllianceGenome:HGNC:19006
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Myak; Nbak2
Summary
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 35.1), testis (RPKM 21.2) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
1p13.2
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (113929324..113977869)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (113940985..113989530)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (114471946..114520491)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene AP4B1 antisense RNA 1 Neighboring gene BCL2 like 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1541 Neighboring gene adaptor related protein complex 4 subunit beta 1 Neighboring gene GATA motif-containing MPRA enhancer 196 Neighboring gene DNA cross-link repair 1B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1217 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1218 Neighboring gene HIPK1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:114480377-114480904 Neighboring gene MPRA-validated peak375 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:114519457-114520034 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:114521340-114522173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:114523841-114524673 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:114525929-114526892 Neighboring gene olfactomedin like 3 Neighboring gene ribosomal protein L13a pseudogene 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. HIPK1 Inhibition Protects against Pathological Cardiac Hypertrophy by Inhibiting the CREB-C/EBPβ Axis. Bei Y, et al. Adv Sci (Weinh), 2023 Jun. PMID 37098980, Free PMC Article
  2. Identifying HIPK1 as Target of miR-22-3p Enhancing Recombinant Protein Production From HEK 293 Cell by Using Microarray and HTP siRNA Screen. Inwood S, et al. Biotechnol J, 2018 Feb. PMID 28987030, Free PMC Article
  3. HIPK1 drives p53 activation to limit colorectal cancer cell growth. Rey C, et al. Cell Cycle, 2013 Jun 15. PMID 23676219, Free PMC Article
  4. Homeodomain-interacting protein kinase 1 (HIPK1) expression in breast cancer tissues. Park BW, et al. Jpn J Clin Oncol, 2012 Dec. PMID 23071292
  5. MicroRNA-889-3p restrains the proliferation and epithelial-mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1. Zhu Q, et al. Bioengineered, 2021 Dec. PMID 34723781, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tyr352 as a Predominant Phosphosite in the Understudied Kinase and Molecular Target, HIPK1: Implications for Cancer Therapy.
    Title: Tyr352 as a Predominant Phosphosite in the Understudied Kinase and Molecular Target, HIPK1: Implications for Cancer Therapy.
  2. HIPK1 Inhibition Protects against Pathological Cardiac Hypertrophy by Inhibiting the CREB-C/EBPbeta Axis.
    Title: HIPK1 Inhibition Protects against Pathological Cardiac Hypertrophy by Inhibiting the CREB-C/EBPβ Axis.
  3. Downregulation of circ-ZNF644 alleviates LPS-induced HK2 cell injury via miR-335-5p/HIPK1 axis.
    Title: Downregulation of circ-ZNF644 alleviates LPS-induced HK2 cell injury via miR-335-5p/HIPK1 axis.
  4. MicroRNA-889-3p restrains the proliferation and epithelial-mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1.
    Title: MicroRNA-889-3p restrains the proliferation and epithelial-mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1.
  5. Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation.
    Title: Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation.
  6. HIPK1, HIPK2 and HIPK3 interact with the components of the carbon catabolite repressor 4 (CCR4)-negative on TATA (NOT) complex, an important regulator of all the major steps in the mRNA metabolism. it has emerged that HIPKs and their related miRNAs are involved in diabetic nephropathy, gastric cancer chemoresistance, cervical cancer progression, and recombinant protein expression in cultured cells. [Review]
    Title: Update on the Regulation of HIPK1, HIPK2 and HIPK3 Protein Kinases by microRNAs.
  7. The data presented here con fi rmed that HIPK1 is involved in the increased expression of recombinant luciferase and the secreted recombinant GPC3-hFc from HEK 293 cells following transfection with miR-22-3p.
    Title: Identifying HIPK1 as Target of miR-22-3p Enhancing Recombinant Protein Production From HEK 293 Cell by Using Microarray and HTP siRNA Screen.
  8. Analysis of these mutants revealed that HIPK1, HIPK2 and HIPK3 but not HIPK4 are capable of autophosphorylating on other tyrosines
    Title: Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).
  9. PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1.
    Title: Cancer/testis antigen PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1, a component of the stress-response pathway.
  10. HIPK1 drives p53 activation to limit colorectal cancer cell growth.
    Title: HIPK1 drives p53 activation to limit colorectal cancer cell growth.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0630, MGC26642, MGC33446, MGC33548

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in adherens junction assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
  
involved_in cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in definitive hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in embryonic camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic retina morphogenesis in camera-type eye IEA
Inferred from Electronic Annotation
more info
  
involved_in endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in eye development ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iris morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in lens induction in camera-type eye IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retina layer formation IEA
Inferred from Electronic Annotation
more info
  
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in PML body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
homeodomain-interacting protein kinase 1
Names
homeodomain interacting protein kinase 1-like protein
nuclear body associated kinase 2b
nuclear body-associated kinase 2
NP_001356735.1
NP_001356736.1
NP_001397776.1
NP_689909.2
NP_852003.1
NP_938009.1
NP_938010.1
XP_005270667.2
XP_005270668.2
XP_006710506.2
XP_011539279.2
XP_047305075.1
XP_047305084.1
XP_047305085.1
XP_047305086.1
XP_047305090.1
XP_047305095.1
XP_054191016.1
XP_054191017.1
XP_054191018.1
XP_054191019.1
XP_054191020.1
XP_054191021.1
XP_054191022.1
XP_054191023.1
XP_054191024.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369806.1 → NP_001356735.1  homeodomain-interacting protein kinase 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL137856, AL731797
    Consensus CDS
    CCDS867.1
    UniProtKB/Swiss-Prot
    A6NJ34, O75125, Q5SQL2, Q5SQL4, Q5SQL5, Q86Z02, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1
    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
    Related
    ENSP00000358571.1, ENST00000369558.5
    Conserved Domains (1) summary
    cd14228
    Location:174 → 528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1

  2. NM_001369807.1 → NP_001356736.1  homeodomain-interacting protein kinase 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL137856, AL731797
    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
    Conserved Domains (1) summary
    cd14228
    Location:174 → 528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1

  3. NM_001410847.1 → NP_001397776.1  homeodomain-interacting protein kinase 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL137856, AL731797
    Consensus CDS
    CCDS91025.1
    UniProtKB/TrEMBL
    J3KP92
    Related
    ENSP00000358574.4, ENST00000369561.8

  4. NM_152696.4 → NP_689909.2  homeodomain-interacting protein kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_689909.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a distinct 3' UTR and coding region, compared to variant 1. This results in a protein (isoform 2) which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB089957, AL137856, BC033012
    Consensus CDS
    CCDS868.1
    UniProtKB/TrEMBL
    B3KV38
    Related
    ENSP00000358572.4, ENST00000369559.8
    Conserved Domains (2) summary
    smart00220
    Location:190 → 518
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14228
    Location:174 → 528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1

  5. NM_181358.3 → NP_852003.1  homeodomain-interacting protein kinase 1 isoform 4

    See identical proteins and their annotated locations for NP_852003.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks one 5' coding exon, compared to variant 1. These differences result in the use of a downstream translation initiation site and a protein (isoform 4) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA995033, AK302726, AL731797, BC033012, BC036057
    Consensus CDS
    CCDS869.1
    UniProtKB/Swiss-Prot
    Q86Z02
    UniProtKB/TrEMBL
    B4DZ33
    Related
    ENSP00000358566.1, ENST00000369553.5
    Conserved Domains (2) summary
    COG0515
    Location:51 → 225
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cl21453
    Location:6 → 134
    PKc_like; Protein Kinases, catalytic domain

  6. NM_198268.3 → NP_938009.1  homeodomain-interacting protein kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_938009.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA995033, AK302726, AL137856, AL731797, BC033012
    Consensus CDS
    CCDS867.1
    UniProtKB/Swiss-Prot
    A6NJ34, O75125, Q5SQL2, Q5SQL4, Q5SQL5, Q86Z02, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1
    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
    Related
    ENSP00000407442.3, ENST00000426820.7
    Conserved Domains (1) summary
    cd14228
    Location:174 → 528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1

  7. NM_198269.3 → NP_938010.1  homeodomain-interacting protein kinase 1 isoform 3

    See identical proteins and their annotated locations for NP_938010.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks one 5' coding exon, compared to variant 1. These differences result in the use of a downstream translation initiation site and a protein (isoform 3) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA995033, AK302726, AL731797, BC028408
    Consensus CDS
    CCDS41370.1
    Related
    ENSP00000340956.4, ENST00000340480.8
    Conserved Domains (2) summary
    COG0515
    Location:71 → 245
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cl21453
    Location:1 → 154
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    113929324..113977869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270611.6 → XP_005270668.2  homeodomain-interacting protein kinase 1 isoform X2

    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
    Conserved Domains (1) summary
    cd14228
    Location:174 → 528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1

  2. XM_005270610.6 → XP_005270667.2  homeodomain-interacting protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
    Conserved Domains (1) summary
    cd14228
    Location:174 → 528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1

  3. XM_047449119.1 → XP_047305075.1  homeodomain-interacting protein kinase 1 isoform X3

  4. XM_006710443.5 → XP_006710506.2  homeodomain-interacting protein kinase 1 isoform X4

    UniProtKB/TrEMBL
    A6NDY4, J3KP92, Q5SQL3
    Conserved Domains (1) summary
    cd14228
    Location:174 → 528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1

  5. XM_047449130.1 → XP_047305086.1  homeodomain-interacting protein kinase 1 isoform X8

  6. XM_047449128.1 → XP_047305084.1  homeodomain-interacting protein kinase 1 isoform X5

  7. XM_011540977.4 → XP_011539279.2  homeodomain-interacting protein kinase 1 isoform X6

    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
    Conserved Domains (1) summary
    cl21453
    Location:174 → 488
    PKc_like; Protein Kinases, catalytic domain

  8. XM_047449129.1 → XP_047305085.1  homeodomain-interacting protein kinase 1 isoform X7

  9. XM_047449139.1 → XP_047305095.1  homeodomain-interacting protein kinase 1 isoform X9

    UniProtKB/Swiss-Prot
    A6NJ34, O75125, Q5SQL2, Q5SQL4, Q5SQL5, Q86Z02, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1

  10. XM_047449134.1 → XP_047305090.1  homeodomain-interacting protein kinase 1 isoform X9

    UniProtKB/Swiss-Prot
    A6NJ34, O75125, Q5SQL2, Q5SQL4, Q5SQL5, Q86Z02, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    113940985..113989530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335042.1 → XP_054191017.1  homeodomain-interacting protein kinase 1 isoform X2

  2. XM_054335041.1 → XP_054191016.1  homeodomain-interacting protein kinase 1 isoform X1

  3. XM_054335043.1 → XP_054191018.1  homeodomain-interacting protein kinase 1 isoform X3

  4. XM_054335044.1 → XP_054191019.1  homeodomain-interacting protein kinase 1 isoform X4

    UniProtKB/TrEMBL
    J3KP92

  5. XM_054335048.1 → XP_054191023.1  homeodomain-interacting protein kinase 1 isoform X8

  6. XM_054335045.1 → XP_054191020.1  homeodomain-interacting protein kinase 1 isoform X5

  7. XM_054335046.1 → XP_054191021.1  homeodomain-interacting protein kinase 1 isoform X6

  8. XM_054335047.1 → XP_054191022.1  homeodomain-interacting protein kinase 1 isoform X7

  9. XM_054335049.1 → XP_054191024.1  homeodomain-interacting protein kinase 1 isoform X9

    UniProtKB/Swiss-Prot
    A6NJ34, O75125, Q5SQL2, Q5SQL4, Q5SQL5, Q86Z02, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86Z02.1 GenPept UniProtKB/Swiss-Prot:Q86Z02

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