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Tfpi tissue factor pathway inhibitor [ Rattus norvegicus (Norway rat) ]

Gene ID: 29436, updated on 4-Jan-2025

Summary

Official Symbol
Tfpiprovided by RGD
Official Full Name
tissue factor pathway inhibitorprovided by RGD
Primary source
RGD:61914
See related
EnsemblRapid:ENSRNOG00000005039 AllianceGenome:RGD:61914
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in cellular response to interleukin-1; cellular response to lipopolysaccharide; and response to estradiol. Located in extracellular space. Biomarker of atrial fibrillation; disseminated intravascular coagulation; myocardial infarction; and osteonecrosis. Human ortholog(s) of this gene implicated in several diseases, including factor VIII deficiency; osteonecrosis; thrombophilia (multiple); toxic shock syndrome; and transient cerebral ischemia. Orthologous to human TFPI (tissue factor pathway inhibitor). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 279.1), Lung (RPKM 156.3) and 9 other tissues See more
Orthologs
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Genomic context

See Tfpi in Genome Data Viewer
Location:
3q24
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (89939862..89989253, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (69533156..69582547, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (71852738..71902127, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486293 Neighboring gene calcitonin receptor like receptor Neighboring gene uncharacterized LOC134486403 Neighboring gene uncharacterized LOC134486404 Neighboring gene uncharacterized LOC108350412

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in caveola  
located_in cell surface  
located_in extracellular region  
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in extracellular space  

General protein information

Preferred Names
tissue factor pathway inhibitor
Names
EPI
LACI
extrinsic pathway inhibitor
lipoprotein-associated coagulation inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177321.1 → NP_001170792.1  tissue factor pathway inhibitor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001170792.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC087020
    UniProtKB/TrEMBL
    A0A8I5Y6C8, Q5PQU8
    Conserved Domains (1) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
  2. NM_017200.1 → NP_058896.1  tissue factor pathway inhibitor isoform 1 precursor

    See identical proteins and their annotated locations for NP_058896.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    D10926
    UniProtKB/Swiss-Prot
    Q02445
    UniProtKB/TrEMBL
    A0A8L2Q2B4, A6HMQ1
    Related
    ENSRNOP00000078992.2, ENSRNOT00000100291.2
    Conserved Domains (2) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:221 → 272
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    89939862..89989253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008761981.4 → XP_008760203.1  tissue factor pathway inhibitor isoform X1

    See identical proteins and their annotated locations for XP_008760203.1

    UniProtKB/TrEMBL
    A0A8L2Q2B4
    Related
    ENSRNOP00000006787.6, ENSRNOT00000006787.9
    Conserved Domains (2) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:225 → 276
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
  2. XM_063283202.1 → XP_063139272.1  tissue factor pathway inhibitor isoform X2

    UniProtKB/Swiss-Prot
    Q02445
    UniProtKB/TrEMBL
    A0A8L2Q2B4, A6HMQ1
  3. XM_039104441.2 → XP_038960369.1  tissue factor pathway inhibitor isoform X2

    UniProtKB/Swiss-Prot
    Q02445
    UniProtKB/TrEMBL
    A0A8L2Q2B4, A6HMQ1
    Conserved Domains (2) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:221 → 272
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
  4. XM_063283203.1 → XP_063139273.1  tissue factor pathway inhibitor isoform X2

    UniProtKB/Swiss-Prot
    Q02445
    UniProtKB/TrEMBL
    A0A8L2Q2B4, A6HMQ1
  5. XM_008761982.2 → XP_008760204.1  tissue factor pathway inhibitor isoform X1

    See identical proteins and their annotated locations for XP_008760204.1

    UniProtKB/TrEMBL
    A0A8L2Q2B4
    Conserved Domains (2) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:225 → 276
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
  6. XM_008761980.4 → XP_008760202.1  tissue factor pathway inhibitor isoform X1

    See identical proteins and their annotated locations for XP_008760202.1

    UniProtKB/TrEMBL
    A0A8L2Q2B4
    Conserved Domains (2) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:225 → 276
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
  7. XM_006234440.5 → XP_006234502.1  tissue factor pathway inhibitor isoform X2

    See identical proteins and their annotated locations for XP_006234502.1

    UniProtKB/Swiss-Prot
    Q02445
    UniProtKB/TrEMBL
    A0A8L2Q2B4, A6HMQ1
    Conserved Domains (2) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:221 → 272
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
  8. XM_006234441.4 → XP_006234503.1  tissue factor pathway inhibitor isoform X2

    See identical proteins and their annotated locations for XP_006234503.1

    UniProtKB/Swiss-Prot
    Q02445
    UniProtKB/TrEMBL
    A0A8L2Q2B4, A6HMQ1
    Conserved Domains (2) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:221 → 272
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
  9. XM_008761983.4 → XP_008760205.1  tissue factor pathway inhibitor isoform X1

    See identical proteins and their annotated locations for XP_008760205.1

    UniProtKB/TrEMBL
    A0A8L2Q2B4
    Conserved Domains (2) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:225 → 276
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
  10. XM_008761984.4 → XP_008760206.1  tissue factor pathway inhibitor isoform X1

    See identical proteins and their annotated locations for XP_008760206.1

    UniProtKB/TrEMBL
    A0A8L2Q2B4
    Conserved Domains (2) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:225 → 276
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
  11. XM_006234444.4 → XP_006234506.1  tissue factor pathway inhibitor isoform X2

    See identical proteins and their annotated locations for XP_006234506.1

    UniProtKB/Swiss-Prot
    Q02445
    UniProtKB/TrEMBL
    A0A8L2Q2B4, A6HMQ1
    Conserved Domains (2) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:221 → 272
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
  12. XM_063283204.1 → XP_063139274.1  tissue factor pathway inhibitor isoform X4

    UniProtKB/TrEMBL
    A0A8I5Y6C8, Q5PQU8
    Related
    ENSRNOP00000054493.2, ENSRNOT00000057685.6
  13. XM_063283208.1 → XP_063139278.1  tissue factor pathway inhibitor isoform X6

    UniProtKB/TrEMBL
    A0A8I5Y6C8
  14. XM_063283206.1 → XP_063139276.1  tissue factor pathway inhibitor isoform X4

    UniProtKB/TrEMBL
    A0A8I5Y6C8, Q5PQU8
  15. XM_063283210.1 → XP_063139280.1  tissue factor pathway inhibitor isoform X6

    UniProtKB/TrEMBL
    A0A8I5Y6C8
  16. XM_039104442.2 → XP_038960370.1  tissue factor pathway inhibitor isoform X6

    UniProtKB/TrEMBL
    A0A8I5Y6C8
    Conserved Domains (1) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
  17. XM_008761986.4 → XP_008760208.1  tissue factor pathway inhibitor isoform X5

    UniProtKB/TrEMBL
    A0A8I5Y6C8
    Conserved Domains (1) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
  18. XM_008761985.3 → XP_008760207.1  tissue factor pathway inhibitor isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y6C8
    Conserved Domains (1) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
  19. XM_063283205.1 → XP_063139275.1  tissue factor pathway inhibitor isoform X4

    UniProtKB/TrEMBL
    A0A8I5Y6C8, Q5PQU8
  20. XM_063283207.1 → XP_063139277.1  tissue factor pathway inhibitor isoform X4

    UniProtKB/TrEMBL
    A0A8I5Y6C8, Q5PQU8
  21. XM_063283209.1 → XP_063139279.1  tissue factor pathway inhibitor isoform X6

    UniProtKB/TrEMBL
    A0A8I5Y6C8
  22. XM_063283211.1 → XP_063139281.1  tissue factor pathway inhibitor isoform X6

    UniProtKB/TrEMBL
    A0A8I5Y6C8
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