U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lat2 linker for activation of T cells family, member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 317676, updated on 2-May-2024

Summary

Go to the top of the page Help
Official Symbol
Lat2provided by RGD
Official Full Name
linker for activation of T cells family, member 2provided by RGD
Primary source
RGD:631397
See related
Ensembl:ENSRNOG00000021856 AllianceGenome:RGD:631397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ntal; Wbscr5
Summary
Predicted to enable SH2 domain binding activity. Predicted to be involved in B cell activation; B cell receptor signaling pathway; and calcium-mediated signaling. Predicted to be located in membrane raft. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human LAT2 (linker for activation of T cells family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 196.5), Thymus (RPKM 57.7) and 7 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
12q12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (27740647..27754760)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (22104173..22118294)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (25114099..25128381)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S14 pseudogene Neighboring gene eukaryotic translation initiation factor 4H Neighboring gene replication factor C subunit 2 Neighboring gene uncharacterized LOC102553558

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Topography of plasma membrane microdomains and its consequences for mast cell signaling. Heneberg P, et al. Eur J Immunol, 2006 Oct. PMID 17013982
  2. Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis. Kurayama R, et al. Lab Invest, 2011 Jul. PMID 21403644
  3. Regulation of Ca2+ signaling in mast cells by tyrosine-phosphorylated and unphosphorylated non-T cell activation linker. Dráberová L, et al. J Immunol, 2007 Oct 15. PMID 17911602
  4. Induction of inducible nitric oxide synthase expression in ammonia-exposed cultured astrocytes is coupled to increased arginine transport by upregulated y(+)LAT2 transporter. Zielińska M, et al. J Neurochem, 2015 Dec. PMID 26448619
  5. Ammonia Reduces Intracellular Asymmetric Dimethylarginine in Cultured Astrocytes Stimulating Its y⁺LAT2 Carrier-Mediated Loss. Milewski K, et al. Int J Mol Sci, 2017 Nov 2. PMID 29099056, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that increased asymmetric dimethylarginine (ADMA) efflux mediated by upregulated yLAT2 may be a mechanism by which ammonia interferes with intra-astrocytic (and possibly intra-endothelial cell) ADMA content and subsequently, NO synthesis in both cell types.
    Title: Ammonia Reduces Intracellular Asymmetric Dimethylarginine in Cultured Astrocytes Stimulating Its y⁺LAT2 Carrier-Mediated Loss.
  2. Up-regulation of y(+)LAT2 transporter is coupled with increased inducible nitric oxide synthase (iNOS) expression
    Title: Induction of inducible nitric oxide synthase expression in ammonia-exposed cultured astrocytes is coupled to increased arginine transport by upregulated y(+)LAT2 transporter.
  3. chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI, tetraspanin CD9, transmembrane adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins of the ERM family
    Title: Cross-talk between tetraspanin CD9 and transmembrane adaptor protein non-T cell activation linker (NTAL) in mast cell activation and chemotaxis.
  4. The Saturday night forecast called for possible showers or thunderstorms, with winds of 20 to 26 mph. The expected total rainfall Saturday ranges from six-tenths of an inch to an inch, with more possible in thunderstorms, the weather service said.
    Title: Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis.
  5. LAT2 and LAT1 form separate membrane microdomains in rat basophilic leukemia cells.
    Title: Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL.
  6. LAT2 colocalizes with Thy-1 (CD90); their colocalization is enhanced following Thy-1 aggregation.
    Title: Topography of plasma membrane microdomains and its consequences for mast cell signaling.
  7. Regulates Fc epsilon type I (IgE) receptor-mediated signaling at multiple steps and by different mechanisms in mast cells.
    Title: Regulation of Ca2+ signaling in mast cells by tyrosine-phosphorylated and unphosphorylated non-T cell activation linker.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in B cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in B cell activation IEA
Inferred from Electronic Annotation
more info
  
involved_in B cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in immune response-regulating signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in mast cell degranulation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
linker for activation of T-cells family member 2
Names
LAT-2 like
Williams-Beuren syndrome chromosome region 5 homolog
Williams-Beuren syndrome chromosome region 5-like protein
linker for activation of B-cells
non-T cell activation linker

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173840.2 → NP_776212.2  linker for activation of T-cells family member 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6J0I1
    Related
    ENSRNOP00000031304.4, ENSRNOT00000034629.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    27740647..27754760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089532.2 → XP_038945460.1  linker for activation of T-cells family member 2 isoform X3

    Conserved Domains (1) summary
    pfam15703
    Location:51 → 103
    LAT2; Linker for activation of T-cells family member 2

  2. XM_039089533.2 → XP_038945461.1  linker for activation of T-cells family member 2 isoform X4

    Conserved Domains (1) summary
    pfam15703
    Location:51 → 103
    LAT2; Linker for activation of T-cells family member 2

  3. XM_017598358.3 → XP_017453847.2  linker for activation of T-cells family member 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZWF7, A6J0I2
    Related
    ENSRNOP00000083189.1
    Conserved Domains (1) summary
    pfam15703
    Location:51 → 207
    LAT2; Linker for activation of T-cells family member 2

  4. XM_039089531.2 → XP_038945459.1  linker for activation of T-cells family member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8CGL2
    Conserved Domains (1) summary
    pfam15703
    Location:51 → 219
    LAT2; Linker for activation of T-cells family member 2

  5. XM_039089534.2 → XP_038945462.1  linker for activation of T-cells family member 2 isoform X5

    Conserved Domains (1) summary
    pfam15703
    Location:1 → 127
    LAT2; Linker for activation of T-cells family member 2

RNA

  1. XR_005491642.2 RNA Sequence

  2. XR_005491643.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CGL2.1 GenPept UniProtKB/Swiss-Prot:Q8CGL2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous