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Zfr zinc finger RNA binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 365703, updated on 2-May-2024

Summary

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Official Symbol
Zfrprovided by RGD
Official Full Name
zinc finger RNA binding proteinprovided by RGD
Primary source
RGD:1311890
See related
Ensembl:ENSRNOG00000011627 AllianceGenome:RGD:1311890
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable double-stranded RNA binding activity and single-stranded RNA binding activity. Predicted to be located in chromosome; cytoplasm; and nucleus. Orthologous to human ZFR (zinc finger RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 418.9), Adrenal (RPKM 240.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q16
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (62864333..62927377)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (61137611..61200322)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (62150251..62213048)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101085 Neighboring gene uncharacterized LOC134485601 Neighboring gene U6 spliceosomal RNA Neighboring gene myotubularin related protein 12 Neighboring gene uncharacterized LOC134485602 Neighboring gene uncharacterized LOC120101086

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The zinc-finger protein ZFR is critical for Staufen 2 isoform specific nucleocytoplasmic shuttling in neurons. Elvira G, et al. J Neurochem, 2006 Jan. PMID 16277607
  2. Structural Analysis of Hippocampal Kinase Signal Transduction. McClatchy DB, et al. ACS Chem Neurosci, 2018 Dec 19. PMID 30053369, Free PMC Article
  3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger RNA-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270972.1 → NP_001257901.1  zinc finger RNA-binding protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q562A2
    UniProtKB/TrEMBL
    A0A0H2UHJ5
    Related
    ENSRNOP00000016196.6, ENSRNOT00000016196.7
    Conserved Domains (4) summary
    smart00572
    Location:784 → 1038
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    PHA03255
    Location:382 → 551
    PHA03255; BDLF3; Provisional
    smart00451
    Location:581 → 612
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:333 → 355
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    62864333..62927377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282250.1 → XP_063138320.1  zinc finger RNA-binding protein isoform X2

  2. XM_039102742.2 → XP_038958670.1  zinc finger RNA-binding protein isoform X5

    UniProtKB/Swiss-Prot
    Q562A2
    UniProtKB/TrEMBL
    A6KJQ3
    Conserved Domains (4) summary
    smart00572
    Location:720 → 974
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    PHA03255
    Location:350 → 487
    PHA03255; BDLF3; Provisional
    smart00451
    Location:517 → 548
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:520 → 542
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_006232054.5 → XP_006232116.1  zinc finger RNA-binding protein isoform X3

    UniProtKB/Swiss-Prot
    Q562A2
    UniProtKB/TrEMBL
    A0A0G2K6C9
    Related
    ENSRNOP00000073762.2
    Conserved Domains (4) summary
    smart00572
    Location:747 → 1001
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    PHA03255
    Location:345 → 514
    PHA03255; BDLF3; Provisional
    smart00451
    Location:544 → 575
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:296 → 318
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_017590988.3 → XP_017446477.1  zinc finger RNA-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q562A2
    UniProtKB/TrEMBL
    A0A8L2RAI7
    Related
    ENSRNOP00000075053.2
    Conserved Domains (4) summary
    smart00572
    Location:792 → 1046
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    PHA03255
    Location:390 → 559
    PHA03255; BDLF3; Provisional
    smart00451
    Location:589 → 620
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:341 → 363
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_017590989.3 → XP_017446478.1  zinc finger RNA-binding protein isoform X4

    UniProtKB/Swiss-Prot
    Q562A2
    Conserved Domains (4) summary
    smart00572
    Location:728 → 982
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    PHA03255
    Location:358 → 495
    PHA03255; BDLF3; Provisional
    smart00451
    Location:525 → 556
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:528 → 550
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_063282251.1 → XP_063138321.1  zinc finger RNA-binding protein isoform X6

RNA

  1. XR_010063629.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q562A2.2 GenPept UniProtKB/Swiss-Prot:Q562A2

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