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CEACAM6 CEA cell adhesion molecule 6 [ Homo sapiens (human) ]

Gene ID: 4680, updated on 4-Jan-2025

Summary

Official Symbol
CEACAM6provided by HGNC
Official Full Name
CEA cell adhesion molecule 6provided by HGNC
Primary source
HGNC:HGNC:1818
See related
Ensembl:ENSG00000086548 MIM:163980; AllianceGenome:HGNC:1818
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCA; CEAL; CD66c; NCA-50/90
Summary
This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]
Expression
Biased expression in colon (RPKM 147.4), lung (RPKM 142.2) and 9 other tissues See more
Orthologs
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Genomic context

See CEACAM6 in Genome Data Viewer
Location:
19q13.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41755530..41772211)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44574887..44591561)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42259438..42276116)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CEA cell adhesion molecule 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10670 Neighboring gene CEA cell adhesion molecule 5 Neighboring gene uncharacterized LOC112268252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42282657-42283158 Neighboring gene CEA cell adhesion molecule 1 pseudogene Neighboring gene CEA cell adhesion molecule 3 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 52

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in apical plasma membrane PubMed 
located_in azurophil granule membrane  
is_active_in cell surface  
located_in cell surface PubMed 
located_in cell surface PubMed 
located_in extracellular space PubMed 
located_in membrane PubMed 
located_in plasma membrane  
located_in side of membrane  

General protein information

Preferred Names
cell adhesion molecule CEACAM6; carcinoembryonic antigen-related cell adhesion molecule 6
Names
Cluster of Differentiation 66c
carcinoembryonic antigen related cell adhesion molecule 6
carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
normal cross-reacting antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002483.7NP_002474.4  cell adhesion molecule CEACAM6 preproprotein

    See identical proteins and their annotated locations for NP_002474.4

    Status: REVIEWED

    Source sequence(s)
    AC243967, AK312542, BC005008, DA763751, M18728
    Consensus CDS
    CCDS12585.1
    UniProtKB/Swiss-Prot
    P40199, Q13774, Q14920, Q53XP7
    Related
    ENSP00000199764.6, ENST00000199764.7
    Conserved Domains (3) summary
    cd05740
    Location:146234
    IgI_hCEACAM_2_4_6_like; Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains
    cd05774
    Location:36140
    IgV_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cd20948
    Location:243318
    IgC2_CEACAM5-like; Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains; member of the C2-set IgSF domains

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    41755530..41772211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526990.3XP_011525292.1  carcinoembryonic antigen-related cell adhesion molecule 6 isoform X1

    See identical proteins and their annotated locations for XP_011525292.1

    Conserved Domains (4) summary
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:244312
    IG_like; Immunoglobulin like
    pfam13895
    Location:240318
    Ig_2; Immunoglobulin domain
    cl11960
    Location:146234
    Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    44574887..44591561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321068.1XP_054177043.1  carcinoembryonic antigen-related cell adhesion molecule 6 isoform X1

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