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P2RY2 purinergic receptor P2Y2 [ Homo sapiens (human) ]

Gene ID: 5029, updated on 4-Jan-2025

Summary

Official Symbol
P2RY2provided by HGNC
Official Full Name
purinergic receptor P2Y2provided by HGNC
Primary source
HGNC:HGNC:8541
See related
Ensembl:ENSG00000175591 MIM:600041; AllianceGenome:HGNC:8541
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P2U; HP2U; P2U1; P2UR; P2Y2; P2RU1; P2Y2R
Summary
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]
Expression
Broad expression in esophagus (RPKM 5.5), thyroid (RPKM 2.6) and 14 other tissues See more
Orthologs
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Genomic context

See P2RY2 in Genome Data Viewer
Location:
11q13.4
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (73218281..73242427)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (73146472..73170656)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (72929326..72953472)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5224 Neighboring gene imatinib upregulated ABL suppressing lncRNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5225 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5226 Neighboring gene Sharpr-MPRA regulatory region 14106 Neighboring gene uncharacterized LOC124902709 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72929160-72929878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72929879-72930597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5227 Neighboring gene Sharpr-MPRA regulatory region 2548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:72951367-72952117 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:72953516-72954262 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:72959838-72961037 Neighboring gene uncharacterized LOC105369382 Neighboring gene olfactory receptor family 8 subfamily R member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor.
EBI GWAS Catalog
Genome-wide association study of body mass index in 23 000 individuals with and without asthma.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ37408, MGC20088, MGC40010, DKFZp686H09192

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables A1 adenosine receptor binding  
enables G protein-coupled UTP receptor activity  
enables G protein-coupled purinergic nucleotide receptor activity  
enables protein binding PubMed 
enables signaling receptor activity PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
P2Y purinoceptor 2
Names
ATP receptor
P2U nucleotide receptor
P2U purinoceptor 1
P2U receptor 1
purinergic receptor P2Y, G-protein coupled, 2
purinoceptor P2Y2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002564.4NP_002555.4  P2Y purinoceptor 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Transcript variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AP002761
    Consensus CDS
    CCDS8219.1
    UniProtKB/Swiss-Prot
    B2R9W3, P41231, Q96EM8
    Related
    ENSP00000377222.2, ENST00000393597.7
    Conserved Domains (1) summary
    cd15373
    Location:34317
    7tmA_P2Y2; P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_176071.3NP_788085.3  P2Y purinoceptor 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Transcript variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AP002761
    Consensus CDS
    CCDS8219.1
    UniProtKB/Swiss-Prot
    B2R9W3, P41231, Q96EM8
    Related
    ENSP00000377221.2, ENST00000393596.2
    Conserved Domains (1) summary
    cd15373
    Location:34317
    7tmA_P2Y2; P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_176072.3NP_788086.3  P2Y purinoceptor 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Transcript variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AP002761
    Consensus CDS
    CCDS8219.1
    UniProtKB/Swiss-Prot
    B2R9W3, P41231, Q96EM8
    Related
    ENSP00000310305.2, ENST00000311131.6
    Conserved Domains (1) summary
    cd15373
    Location:34317
    7tmA_P2Y2; P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    73218281..73242427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    73146472..73170656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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