PLC1 phosphatidylinositol phospholipase C [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: PLC1
Gene description: phosphatidylinositol phospholipase C
Primary source: SGD:S000006189
Locus tag: YPL268W
See related: AllianceGenome:SGD:S000006189
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phosphatidylinositol phospholipase C activity. Involved in several processes, including inositol phosphate biosynthetic process; protein localization to kinetochore; and signal transduction involved in filamentous growth. Located in kinetochore. Human ortholog(s) of this gene implicated in several diseases, including developmental and epileptic encephalopathy 12; familial cold autoinflammatory syndrome 3; myelodysplastic syndrome; nonsyndromic congenital nail disorder 3; and spermatogenic failure 17. Orthologous to several human genes including PLCD4 (phospholipase C delta 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (35236..37845)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plc1p and InsPs are required for normal acetyl-CoA homeostasis, which, in turn, regulates global histone acetylation.
Title: Yeast phospholipase C is required for normal acetyl-CoA homeostasis and global histone acetylation.
The results show that MHO1 is a novel synthetic lethal interactor with PLC1, and that both gene products are required for proliferation (MHO1).
Title: MHO1, an evolutionarily conserved gene, is synthetic lethal with PLC1; Mho1p has a role in invasive growth.
Plc1p affects transcription of Mcm1p-dependent genes,probably by a mechanism involving regulation of chromatin remodeling complexes.
Title: Role of Plc1p in regulation of Mcm1p-dependent genes.
Mutations in PLC1 and components of the RSC complex exhibit strong genetic interactions and display synthetic growth defect, altered nuclear morphology, and higher frequency of minichromosome loss.
Title: Plc1p is required for proper chromatin structure and activity of the kinetochore in Saccharomyces cerevisiae by facilitating recruitment of the RSC complex.
Genes regulated by Plc1p do not correlate with gene sets regulated by Swi/Snf or RSC chromatin remodeling complexes but show correlation with genes controlled by Msn2p.
Title: Saccharomyces cerevisiae phospholipase C regulates transcription of Msn2p-dependent stress-responsive genes.
The results thus provide evidence that Plc1p and inositol polyphosphates affect derepression of Sko1p-Ssn6p-Tup1p-controlled genes by a mechanism that involves recruitment of the SAGA complex and TATA-binding protein.
Title: Plc1p is required for SAGA recruitment and derepression of Sko1p-regulated genes.
Data suggest that expression of FLR1 can be regulated by phospholipase C, a component of a signal transduction pathway, and by Mediator, a general transcription factor.
Title: Expression of FLR1 transporter requires phospholipase C and is repressed by Mediator.
Plc1p, Arg82p, and Kcs1p are enzymes involved in inositol pyrophosphate synthesis and are essential for phosphate regulation and polyphosphate accumulation
Title: Plc1p, Arg82p, and Kcs1p, enzymes involved in inositol pyrophosphate synthesis, are essential for phosphate regulation and polyphosphate accumulation in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol phospholipase C activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phospholipase C activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in inositol phosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphate-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction involved in filamentous growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction involved in filamentous growth	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol phospholipase C

NP_015055.1

EC 3.1.4.11

Phospholipase C; hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes; Plc1p and inositol polyphosphates are required for acetyl-CoA homeostasis which regulates global histone acetylation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

35236..37845

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184082.1 → NP_015055.1 TPA: phosphatidylinositol phospholipase C [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015055.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3A2, P32383

UniProtKB/TrEMBL

A0A8H4F6L7, B3LKG5

Conserved Domains (4) summary

cd00275
Location:732 → 868

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08598
Location:379 → 688

PI-PLC1c_yeast; Catalytic domain of putative yeast phosphatidylinositide-specific phospholipases C

PLN02952
Location:284 → 856

PLN02952; phosphoinositide phospholipase C

cd13360
Location:124 → 224

PH_PLC_fungal; Fungal Phospholipase C (PLC) pleckstrin homology (PH) domain