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pstS1 phosphate ABC transporter substrate-binding lipoprotein PstS [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885724, updated on 6-Oct-2023

Summary

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Gene symbol
pstS1
Gene description
phosphate ABC transporter substrate-binding lipoprotein PstS
Locus tag
Rv0934
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
phoS; phoS1
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Genomic context

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Sequence:
NC_000962.3 (1042115..1043239)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene phosphate ABC transporter substrate-binding lipoprotein PstS Neighboring gene phosphate ABC transporter ATP-binding protein PstB Neighboring gene phosphate ABC transporter permease PstC Neighboring gene phosphate ABC transporter permease PstA Neighboring gene non-homologous end joining protein Ku

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. pstS1 polymorphisms of Mycobacterium tuberculosis strains may reflect ongoing immune evasion. Liu H, et al. Tuberculosis (Edinb), 2013 Sep. PMID 23849889
  2. Monocytes and the 38kDa-antigen of mycobacterium tuberculosis modulate natural killer cell activity and their cytolysis directed against ovarian cancer cell lines. Gottschalk N, et al. BMC Cancer, 2012 Oct 4. PMID 23036052, Free PMC Article
  3. Mycobacterium tuberculosis with disruption in genes encoding the phosphate binding proteins PstS1 and PstS2 is deficient in phosphate uptake and demonstrates reduced in vivo virulence. Peirs P, et al. Infect Immun, 2005 Mar. PMID 15731097, Free PMC Article
  4. PstS-1, the 38-kDa Mycobacterium tuberculosis glycoprotein, is an adhesin, which binds the macrophage mannose receptor and promotes phagocytosis. Esparza M, et al. Scand J Immunol, 2015 Jan. PMID 25359607
  5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The interaction of PstS-1 coated beads with the mannose receptor was confirmed by confocal colocalization studies that showed high Pearson and Manders's colocalization coefficients.
    Title: PstS-1, the 38-kDa Mycobacterium tuberculosis glycoprotein, is an adhesin, which binds the macrophage mannose receptor and promotes phagocytosis.
  2. pstS1 polymorphisms of Mycobacterium tuberculosis strains may reflect ongoing immune evasion.
    Title: pstS1 polymorphisms of Mycobacterium tuberculosis strains may reflect ongoing immune evasion.
  3. Data indicate that the modulation of Natural killer (NK) cells by PstS-1 is mediated via monocytes.
    Title: Monocytes and the 38kDa-antigen of mycobacterium tuberculosis modulate natural killer cell activity and their cytolysis directed against ovarian cancer cell lines.
  4. required for phosphate uptake and virulence
    Title: Mycobacterium tuberculosis with disruption in genes encoding the phosphate binding proteins PstS1 and PstS2 is deficient in phosphate uptake and demonstrates reduced in vivo virulence.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
phosphate ABC transporter substrate-binding lipoprotein PstS
YP_177770.1
  • previously known as phoS1 or phoS

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1042115..1043239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_177770.1 phosphate ABC transporter substrate-binding lipoprotein PstS [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for YP_177770.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7W519
    Conserved Domains (1) summary
    TIGR00975
    Location:53 → 373
    3a0107s03; phosphate ABC transporter, phosphate-binding protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WGU1.1

Gene LinkOut

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