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ynaI small conductance mechanosensitive channel YnaI [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945898, updated on 2-May-2024

Summary

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Gene symbol
ynaI
Gene description
small conductance mechanosensitive channel YnaI
Primary source
ECOCYC:G6666
Locus tag
b1330
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1327
Summary
EvgAS regulon. mscS, kefA, yjeP, ybiO, ybdG and ynaI are paralogs. [More information is available at EcoGene: EG13924]. YnaI is a putative member of the small mechanosensitive ion channel MscS family. [More information is available at EcoCyc: G6666].
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Genomic context

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Sequence:
NC_000913.3 (1394891..1395922, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor PgrR Neighboring gene murein tripeptide ABC transporter periplasmic binding protein Neighboring gene IS5 family transposase and trans-activator Neighboring gene DUF2534 domain-containing protein YnaJ

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Structure of YnaI Implies Structural and Mechanistic Conservation in the MscS Family of Mechanosensitive Channels. Böttcher B, et al. Structure, 2015 Sep 1. PMID 26256535, Free PMC Article
  2. The MscS-like channel YnaI has a gating mechanism based on flexible pore helices. Flegler VJ, et al. Proc Natl Acad Sci U S A, 2020 Nov 17. PMID 33148804, Free PMC Article
  3. Identification and mapping of self-assembling protein domains encoded by the Escherichia coli K-12 genome by use of lambda repressor fusions. Mariño-Ramírez L, et al. J Bacteriol, 2004 Mar. PMID 14973045, Free PMC Article
  4. Analysis of the kefA2 mutation suggests that KefA is a cation-specific channel involved in osmotic adaptation in Escherichia coli. McLaggan D, et al. Mol Microbiol, 2002 Jan. PMID 11985727
  5. Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity. Levina N, et al. EMBO J, 1999 Apr 1. PMID 10202137, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The MscS-like channel YnaI has a gating mechanism based on flexible pore helices.
    Title: The MscS-like channel YnaI has a gating mechanism based on flexible pore helices.
  2. High level expression of YnaI proteins from a multicopy plasmid in the Delta7 strain (MJFGH) leads to substantial protection against hypoosmotic shock.
    Title: Characterization of three novel mechanosensitive channel activities in Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mechanosensitive monoatomic ion channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
small conductance mechanosensitive channel YnaI

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1394891..1395922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415846.1 small conductance mechanosensitive channel YnaI [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415846.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A827PX77, A0AA87JZ71
    Conserved Domains (1) summary
    pfam00924
    Location:121 → 323
    MS_channel; Mechanosensitive ion channel
Nucleotide Protein
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