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preA dihydropyrimidine dehydrogenase (NAD(+)) subunit PreA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949037, updated on 4-Apr-2024

Summary

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Gene symbol
preA
Gene description
dihydropyrimidine dehydrogenase (NAD(+)) subunit PreA
Primary source
ASAP:ABE-0007098
Locus tag
b2147
See related
ECOCYC:EG11289
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2140; yeiA
Summary
HT_Cmplx37_Cyt: [More information is available at EcoGene: EG11289]. Based on sequence similarity, YeiA is predicted to be a dihydrothymine dehydrogenase . [More information is available at EcoCyc: EG11289].
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Genomic context

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Sequence:
NC_000913.3 (2235265..2236500)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF218 domain-containing protein SanA Neighboring gene DUF2542 domain-containing protein YeiS Neighboring gene dihydropyrimidine dehydrogenase (NAD(+)) subunit PreT Neighboring gene D-galactose/methyl-galactoside ABC transporter membrane subunit Neighboring gene D-galactose/methyl-galactoside ABC transporter ATP binding subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression and characterization of Escherichia coli dihydropyrimidine dehydrogenase: a four iron-sulphur cluster containing flavoprotein. Yoshioka H, et al. J Biochem, 2021 Dec 4. PMID 34097066
  2. Nucleotide sequence and analysis of the mgl operon of Escherichia coli K12. Hogg RW, et al. Mol Gen Genet, 1991 Oct. PMID 1719366
  3. Escherichia coli dihydropyrimidine dehydrogenase is a novel NAD-dependent heterotetramer essential for the production of 5,6-dihydrouracil. Hidese R, et al. J Bacteriol, 2011 Feb. PMID 21169495, Free PMC Article
  4. The iscS gene deficiency affects the expression of pyrimidine metabolism genes. Mihara H, et al. Biochem Biophys Res Commun, 2008 Aug 1. PMID 18482579
  5. An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR). Reed JL, et al. Genome Biol, 2003. PMID 12952533, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
contributes_to 4 iron, 4 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to FMN binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADH dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to dihydropyrimidine dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dihydropyrimidine dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within bacterial-type flagellum-dependent swarming motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyrimidine nucleobase catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in thymine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in uracil catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of dihydropyrimidine dehydrogenase (NAD+) complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of oxidoreductase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dihydropyrimidine dehydrogenase (NAD(+)) subunit PreA
NP_416652.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2235265..2236500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416652.4 dihydropyrimidine dehydrogenase (NAD(+)) subunit PreA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416652.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AA94SF97, C3T417
    Conserved Domains (1) summary
    PRK08318
    Location:4 → 408
    PRK08318; NAD-dependent dihydropyrimidine dehydrogenase subunit PreA
Nucleotide Protein
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