CDC20 cell division cycle 20 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CDC20provided by HGNC
Official Full Name: cell division cycle 20provided by HGNC
Primary source: HGNC:HGNC:1723
See related: Ensembl:ENSG00000117399 MIM:603618; AllianceGenome:HGNC:1723
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CDC20A; OOMD14; p55CDC; OZEMA14; bA276H19.3
Summary: CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]
Expression: Biased expression in testis (RPKM 26.5), bone marrow (RPKM 19.7) and 12 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p34.2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (43358981..43363203)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (43229529..43233751)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (43824652..43828874)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional analysis of Cdc20 reveals a critical role of CRY box in mitotic checkpoint signaling.
Title: Functional analysis of Cdc20 reveals a critical role of CRY box in mitotic checkpoint signaling.
Functional analysis of recurrent CDC20 promoter variants in human melanoma.
Title: Functional analysis of recurrent CDC20 promoter variants in human melanoma.
The potential role of CDC20 in tumorigenesis, cancer progression and therapy: A narrative review.
Title: The potential role of CDC20 in tumorigenesis, cancer progression and therapy: A narrative review.
Alternative CDC20 translational isoforms tune mitotic arrest duration.
Title: Alternative CDC20 translational isoforms tune mitotic arrest duration.
PRMT6-CDC20 facilitates glioblastoma progression via the degradation of CDKN1B.
Title: PRMT6-CDC20 facilitates glioblastoma progression via the degradation of CDKN1B.
CDC20 inhibition alleviates fibrotic response of renal tubular epithelial cells and fibroblasts by regulating nuclear translocation of beta-catenin.
Title: CDC20 inhibition alleviates fibrotic response of renal tubular epithelial cells and fibroblasts by regulating nuclear translocation of β-catenin.
Current Progress and Perspectives of CDC20 in Female Reproductive Cancers.
Title: Current Progress and Perspectives of CDC20 in Female Reproductive Cancers.
Impaired Cdc20 signaling promotes senescence in normal cells and apoptosis in non-small cell lung cancer cells.
Title: Impaired Cdc20 signaling promotes senescence in normal cells and apoptosis in non-small cell lung cancer cells.
Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer.
Title: Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer.
Knockdown of CDC20 promotes adipogenesis of bone marrow-derived stem cells by modulating beta-catenin.
Title: Knockdown of CDC20 promotes adipogenesis of bone marrow-derived stem cells by modulating β-catenin.

Submit: New GeneRIF Correction See all GeneRIFs (145)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Oocyte maturation defect 14 MedGen: C5830326 OMIM: 620276 GeneReviews: Not available	not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 and the viral protein Tat modulate the expression of cell division cycle 20 (CDC20) in immature dendritic cells and monocyte-derived macrophages	PubMed
	tat	The DNA repair gene DNA-PKcs and cell cycle-related genes Cdc20, Cdc25C, KIF2C and CTS1 are downregulated in HIV-1 Tat-expressing human rhabdomyosarcoma cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A004O43 (e-PCR)
- UniSTS:6416

STS-U05340 (e-PCR)
- UniSTS:47941

RH98782 (e-PCR)
- UniSTS:88429

RH67938 (e-PCR)
- UniSTS:27530

RH12828 (e-PCR)
- UniSTS:40954

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables anaphase-promoting complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables anaphase-promoting complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin ligase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like ligase-substrate adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in anaphase-promoting complex-dependent catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in anaphase-promoting complex-dependent catabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in metaphase/anaphase transition of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in metaphase/anaphase transition of meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid cohesion	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly checkpoint signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mitotic metaphase/anaphase transition	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synapse maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of meiotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of meiotic nuclear division	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IBA Inferred from Biological aspect of Ancestor more info
part_of anaphase-promoting complex	IDA Inferred from Direct Assay more info	PubMed
part_of anaphase-promoting complex	NAS Non-traceable Author Statement more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
part_of mitotic checkpoint complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in spindle	TAS Traceable Author Statement more info	PubMed
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cell division cycle protein 20 homolog

Names: CDC20 cell division cycle 20 homolog; cell division cycle 20 homolog; fizzy homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001255.3 → NP_001246.2 cell division cycle protein 20 homolog

See identical proteins and their annotated locations for NP_001246.2

Status: REVIEWED

Source sequence(s)

BC001088

Consensus CDS

CCDS484.1

UniProtKB/Swiss-Prot

B2R6Z6, D3DPJ1, Q12834, Q5JUY4, Q9BW56, Q9UQI9

UniProtKB/TrEMBL

B4E1H5

Related

ENSP00000308450.5, ENST00000310955.11

Conserved Domains (2) summary

cd00200
Location:190 → 471

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:229 → 266

7WD40; WD40 repeat [structural motif]