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Recurrent Ovarian Germ Cell Tumor

MedGen UID:
79058
•Concept ID:
C0279975
•
Neoplastic Process
Synonyms: Recurrent Germ Cell Neoplasm of Ovary; Recurrent Germ Cell Neoplasm of the Ovary; Recurrent Germ Cell Tumor of Ovary; Recurrent Germ Cell Tumor of the Ovary; Recurrent Ovarian Germ Cell Neoplasm; Relapsed Germ Cell Neoplasm of Ovary; Relapsed Germ Cell Neoplasm of the Ovary; Relapsed Germ Cell Tumor of Ovary; Relapsed Germ Cell Tumor of the Ovary; Relapsed Ovarian Germ Cell Neoplasm; Relapsed Ovarian Germ Cell Tumor

Definition

The reemergence of ovarian germ cell tumor after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Ovarian Germ Cell Tumor

Professional guidelines

PubMed

Contemporary management of ovarian germ cell tumors and remaining controversies.
Veneris JT, Mahajan P, Frazier AL
Gynecol Oncol 2020 Aug;158(2):467-475. Epub 2020 Jun 5 doi: 10.1016/j.ygyno.2020.05.007. PMID: 32507650
Updates in the management of ovarian germ cell tumors.
Matei D, Brown J, Frazier L
Am Soc Clin Oncol Educ Book 2013 doi: 10.14694/EdBook_AM.2013.33.e210. PMID: 23714505
Management of ovarian germ cell tumors.
Gershenson DM
J Clin Oncol 2007 Jul 10;25(20):2938-43. doi: 10.1200/JCO.2007.10.8738. PMID: 17617525

Recent clinical studies

Etiology

Utility of polygenic risk scores in UK cancer screening: a modelling analysis.
Huntley C, Torr B, Sud A, Rowlands CF, Way R, Snape K, Hanson H, Swanton C, Broggio J, Lucassen A, McCartney M, Houlston RS, Hingorani AD, Jones ME, Turnbull C
Lancet Oncol 2023 Jun;24(6):658-668. Epub 2023 May 10 doi: 10.1016/S1470-2045(23)00156-0. PMID: 37178708
Contemporary management of ovarian germ cell tumors and remaining controversies.
Veneris JT, Mahajan P, Frazier AL
Gynecol Oncol 2020 Aug;158(2):467-475. Epub 2020 Jun 5 doi: 10.1016/j.ygyno.2020.05.007. PMID: 32507650
Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline.
Konstantinopoulos PA, Norquist B, Lacchetti C, Armstrong D, Grisham RN, Goodfellow PJ, Kohn EC, Levine DA, Liu JF, Lu KH, Sparacio D, Annunziata CM
J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article
Chemotherapy in ovarian germ cell tumors: A systematic review.
Simone CG, Markham MJ, Dizon DS
Gynecol Oncol 2016 Jun;141(3):602-607. Epub 2016 Feb 9 doi: 10.1016/j.ygyno.2016.02.007. PMID: 26873864
Neonatal teratomas.
Lakhoo K
Early Hum Dev 2010 Oct;86(10):643-7. Epub 2010 Sep 29 doi: 10.1016/j.earlhumdev.2010.08.016. PMID: 20884137

Diagnosis

Ovarian dysgerminoma.
Mohamed A, Ali A, Younis FM
Int J Gynecol Cancer 2022 Nov 7;32(11):1490-1491. doi: 10.1136/ijgc-2022-003978. PMID: 36343973
Contemporary management of ovarian germ cell tumors and remaining controversies.
Veneris JT, Mahajan P, Frazier AL
Gynecol Oncol 2020 Aug;158(2):467-475. Epub 2020 Jun 5 doi: 10.1016/j.ygyno.2020.05.007. PMID: 32507650
Pediatric Gynecologic Cancers.
Pommert L, Bradley W
Curr Oncol Rep 2017 Jul;19(7):44. doi: 10.1007/s11912-017-0604-7. PMID: 28501984
Chemotherapy in ovarian germ cell tumors: A systematic review.
Simone CG, Markham MJ, Dizon DS
Gynecol Oncol 2016 Jun;141(3):602-607. Epub 2016 Feb 9 doi: 10.1016/j.ygyno.2016.02.007. PMID: 26873864
Neonatal teratomas.
Lakhoo K
Early Hum Dev 2010 Oct;86(10):643-7. Epub 2010 Sep 29 doi: 10.1016/j.earlhumdev.2010.08.016. PMID: 20884137

Therapy

Utility of polygenic risk scores in UK cancer screening: a modelling analysis.
Huntley C, Torr B, Sud A, Rowlands CF, Way R, Snape K, Hanson H, Swanton C, Broggio J, Lucassen A, McCartney M, Houlston RS, Hingorani AD, Jones ME, Turnbull C
Lancet Oncol 2023 Jun;24(6):658-668. Epub 2023 May 10 doi: 10.1016/S1470-2045(23)00156-0. PMID: 37178708
Contemporary management of ovarian germ cell tumors and remaining controversies.
Veneris JT, Mahajan P, Frazier AL
Gynecol Oncol 2020 Aug;158(2):467-475. Epub 2020 Jun 5 doi: 10.1016/j.ygyno.2020.05.007. PMID: 32507650
Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline.
Konstantinopoulos PA, Norquist B, Lacchetti C, Armstrong D, Grisham RN, Goodfellow PJ, Kohn EC, Levine DA, Liu JF, Lu KH, Sparacio D, Annunziata CM
J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article
Chemotherapy in ovarian germ cell tumors: A systematic review.
Simone CG, Markham MJ, Dizon DS
Gynecol Oncol 2016 Jun;141(3):602-607. Epub 2016 Feb 9 doi: 10.1016/j.ygyno.2016.02.007. PMID: 26873864
Pathophysiology of cisplatin-induced acute kidney injury.
Ozkok A, Edelstein CL
Biomed Res Int 2014;2014:967826. Epub 2014 Aug 6 doi: 10.1155/2014/967826. PMID: 25165721Free PMC Article

Prognosis

Dysregulated FOXM1 signaling in the regulation of cancer stem cells.
Sher G, Masoodi T, Patil K, Akhtar S, Kuttikrishnan S, Ahmad A, Uddin S
Semin Cancer Biol 2022 Nov;86(Pt 3):107-121. Epub 2022 Aug 2 doi: 10.1016/j.semcancer.2022.07.009. PMID: 35931301
Clinical Characteristics and Mutation Analyses of Ovarian Sertoli-Leydig Cell Tumors.
Yuan Z, Huo X, Jiang D, Yu M, Cao D, Wu H, Shen K, Yang J, Zhang Y, Zhou H, Wang Y
Oncologist 2020 Sep;25(9):e1396-e1405. Epub 2020 Aug 11 doi: 10.1634/theoncologist.2020-0110. PMID: 32557933Free PMC Article
Gynecologic cancer in pregnancy.
Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951Free PMC Article
Chemotherapy in ovarian germ cell tumors: A systematic review.
Simone CG, Markham MJ, Dizon DS
Gynecol Oncol 2016 Jun;141(3):602-607. Epub 2016 Feb 9 doi: 10.1016/j.ygyno.2016.02.007. PMID: 26873864
Management of Ovarian Cancer In Younger Women.
Uma Devi K, Purushotham N, Jayashree N
Rev Recent Clin Trials 2015;10(4):263-9. doi: 10.2174/1574887110666150923112047. PMID: 26411956

Clinical prediction guides

Utility of polygenic risk scores in UK cancer screening: a modelling analysis.
Huntley C, Torr B, Sud A, Rowlands CF, Way R, Snape K, Hanson H, Swanton C, Broggio J, Lucassen A, McCartney M, Houlston RS, Hingorani AD, Jones ME, Turnbull C
Lancet Oncol 2023 Jun;24(6):658-668. Epub 2023 May 10 doi: 10.1016/S1470-2045(23)00156-0. PMID: 37178708
Contemporary management of ovarian germ cell tumors and remaining controversies.
Veneris JT, Mahajan P, Frazier AL
Gynecol Oncol 2020 Aug;158(2):467-475. Epub 2020 Jun 5 doi: 10.1016/j.ygyno.2020.05.007. PMID: 32507650
Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline.
Konstantinopoulos PA, Norquist B, Lacchetti C, Armstrong D, Grisham RN, Goodfellow PJ, Kohn EC, Levine DA, Liu JF, Lu KH, Sparacio D, Annunziata CM
J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article
Laboratory markers and germ cell tumors.
von Eyben FE
Crit Rev Clin Lab Sci 2003 Aug;40(4):377-427. doi: 10.1080/10408360390247814. PMID: 14582602
Germ cell tumors.
Rescorla FJ
Semin Pediatr Surg 1997 Feb;6(1):29-37. PMID: 9117272

Recent systematic reviews

Clinical Utility of Anti-Mullerian Hormone in Pediatrics.
Kanakatti Shankar R, Dowlut-McElroy T, Dauber A, Gomez-Lobo V
J Clin Endocrinol Metab 2022 Jan 18;107(2):309-323. doi: 10.1210/clinem/dgab687. PMID: 34537849Free PMC Article
Prevalence of metachronous contralateral mature ovarian teratoma: A systematic review.
Kiely D, Lewis C, Gray J, Hall N
Pediatr Blood Cancer 2021 Nov;68(11):e29237. Epub 2021 Jul 31 doi: 10.1002/pbc.29237. PMID: 34331503
Short- and Long-Term Complications of Intraoperative Benign Ovarian Cyst Spillage: A Systematic Review and Meta-analysis.
Eisenberg N, Volodarsky-Perel A, Brochu I, Tremblay C, Gorak E, Hudon E, Fortin S, Kogan L, Rivard C
J Minim Invasive Gynecol 2021 May;28(5):957-970. Epub 2020 Dec 3 doi: 10.1016/j.jmig.2020.11.025. PMID: 33279627
Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline.
Konstantinopoulos PA, Norquist B, Lacchetti C, Armstrong D, Grisham RN, Goodfellow PJ, Kohn EC, Levine DA, Liu JF, Lu KH, Sparacio D, Annunziata CM
J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article
Chemotherapy in ovarian germ cell tumors: A systematic review.
Simone CG, Markham MJ, Dizon DS
Gynecol Oncol 2016 Jun;141(3):602-607. Epub 2016 Feb 9 doi: 10.1016/j.ygyno.2016.02.007. PMID: 26873864

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