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Recurrent Extragonadal Seminoma

MedGen UID:
857333
•Concept ID:
C3897739
•
Neoplastic Process

Definition

The reemergence of extragonadal seminoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Extragonadal Seminoma

Professional guidelines

PubMed

Management of Germ Cell Tumours of the Testes in Adult Patients: German Clinical Practice Guideline, PART II - Recommendations for the Treatment of Advanced, Recurrent, and Refractory Disease and Extragonadal and Sex Cord/Stromal Tumours and for the Management of Follow-Up, Toxicity, Quality of Life, Palliative Care, and Supportive Therapy.
Kliesch S, Schmidt S, Wilborn D, Aigner C, Albrecht W, Bedke J, Beintker M, Beyersdorff D, Bokemeyer C, Busch J, Classen J, de Wit M, Dieckmann KP, Diemer T, Dieing A, Gockel M, Göckel-Beining B, Hakenberg OW, Heidenreich A, Heinzelbecker J, Herkommer K, Hermanns T, Kaufmann S, Kornmann M, Kotzerke J, Krege S, Kristiansen G, Lorch A, Müller AC, Oechsle K, Ohloff T, Oing C, Otto U, Pfister D, Pichler R, Recken H, Rick O, Rudolph Y, Ruf C, Schirren J, Schmelz H, Schmidberger H, Schrader M, Schweyer S, Seeling S, Souchon R, Winter C, Wittekind C, Zengerling F, Zermann DH, Zillmann R, Albers P
Urol Int 2021;105(3-4):181-191. Epub 2021 Jan 22 doi: 10.1159/000511245. PMID: 33486494Free PMC Article
Extragonadal seminoma: an international multicenter analysis of prognostic factors and long term treatment outcome.
Bokemeyer C, Droz JP, Horwich A, Gerl A, Fossa SD, Beyer J, Pont J, Schmoll HJ, Kanz L, Einhorn L, Nichols CR, Hartmann JT
Cancer 2001 Apr 1;91(7):1394-401. PMID: 11283942
The treatment of extragonadal seminoma.
Jain KK, Bosl GJ, Bains MS, Whitmore WF, Golbey RB
J Clin Oncol 1984 Jul;2(7):820-7. doi: 10.1200/JCO.1984.2.7.820. PMID: 6204019

Recent clinical studies

Etiology

Cisplatin-based chemotherapy for advanced seminoma: report of 52 cases treated in two institutions.
Giannis M, Aristotelis B, Vassiliki K, Ioannis A, Konstantinos S, Nikolaos A, Georgios P, Georgios P, Pantelis P, Meletios-Athanasios D
J Cancer Res Clin Oncol 2009 Nov;135(11):1495-500. Epub 2009 May 13 doi: 10.1007/s00432-009-0596-2. PMID: 19437039
Clinical and biological significance of CXCL12 and CXCR4 expression in adult testes and germ cell tumours of adults and adolescents.
Gilbert DC, Chandler I, McIntyre A, Goddard NC, Gabe R, Huddart RA, Shipley J
J Pathol 2009 Jan;217(1):94-102. doi: 10.1002/path.2436. PMID: 18839394
Extragonadal seminoma: an international multicenter analysis of prognostic factors and long term treatment outcome.
Bokemeyer C, Droz JP, Horwich A, Gerl A, Fossa SD, Beyer J, Pont J, Schmoll HJ, Kanz L, Einhorn L, Nichols CR, Hartmann JT
Cancer 2001 Apr 1;91(7):1394-401. PMID: 11283942
Salvage chemotherapy with vinblastine, ifosfamide, and cisplatin in recurrent seminoma.
Miller KD, Loehrer PJ, Gonin R, Einhorn LH
J Clin Oncol 1997 Apr;15(4):1427-31. doi: 10.1200/JCO.1997.15.4.1427. PMID: 9193335
The treatment of extragonadal seminoma.
Jain KK, Bosl GJ, Bains MS, Whitmore WF, Golbey RB
J Clin Oncol 1984 Jul;2(7):820-7. doi: 10.1200/JCO.1984.2.7.820. PMID: 6204019

Diagnosis

Management of Germ Cell Tumours of the Testes in Adult Patients: German Clinical Practice Guideline, PART II - Recommendations for the Treatment of Advanced, Recurrent, and Refractory Disease and Extragonadal and Sex Cord/Stromal Tumours and for the Management of Follow-Up, Toxicity, Quality of Life, Palliative Care, and Supportive Therapy.
Kliesch S, Schmidt S, Wilborn D, Aigner C, Albrecht W, Bedke J, Beintker M, Beyersdorff D, Bokemeyer C, Busch J, Classen J, de Wit M, Dieckmann KP, Diemer T, Dieing A, Gockel M, Göckel-Beining B, Hakenberg OW, Heidenreich A, Heinzelbecker J, Herkommer K, Hermanns T, Kaufmann S, Kornmann M, Kotzerke J, Krege S, Kristiansen G, Lorch A, Müller AC, Oechsle K, Ohloff T, Oing C, Otto U, Pfister D, Pichler R, Recken H, Rick O, Rudolph Y, Ruf C, Schirren J, Schmelz H, Schmidberger H, Schrader M, Schweyer S, Seeling S, Souchon R, Winter C, Wittekind C, Zengerling F, Zermann DH, Zillmann R, Albers P
Urol Int 2021;105(3-4):181-191. Epub 2021 Jan 22 doi: 10.1159/000511245. PMID: 33486494Free PMC Article
Primary Extramedullary, Extradural Cervical Spine Seminoma.
Long C, Novack TA, Changoor S, Sinha K, Hwang KS, Faloon MJ, Emami A
J Am Acad Orthop Surg Glob Res Rev 2020 Jul;4(7):e1900177. doi: 10.5435/JAAOSGlobal-D-19-00177. PMID: 32672721Free PMC Article
Mixed extragonadal germ cell tumour of the prostate.
Antunes HP, Almeida R, Sousa V, Figueiredo A
BMJ Case Rep 2018 Jul 10;2018 doi: 10.1136/bcr-2017-223603. PMID: 29991542Free PMC Article
Primary retroperitoneal seminoma - embryology, histopathology and treatment particularities.
Gîngu CV, Mihai M, Baston C, Crăsneanu MA, Dick AV, Olaru V, Sinescu I
Rom J Morphol Embryol 2016;57(3):1045-1050. PMID: 28002522
Extragonadal seminoma: an international multicenter analysis of prognostic factors and long term treatment outcome.
Bokemeyer C, Droz JP, Horwich A, Gerl A, Fossa SD, Beyer J, Pont J, Schmoll HJ, Kanz L, Einhorn L, Nichols CR, Hartmann JT
Cancer 2001 Apr 1;91(7):1394-401. PMID: 11283942

Therapy

Late testicular relapse two decades after primary extragonadal germ cell tumor with uncommon metastases: a case report.
Tobiume M, Aoki S, Nishikawa G, Muramatsu H, Ono K, Morinaga S, Hara K, Ando N, Ono K, Nishibata C, Hidano A, Nakagawa M, Takahashi I, Matsubara K, Yamada Y
J Med Case Rep 2021 Feb 5;15(1):59. doi: 10.1186/s13256-021-02667-y. PMID: 33541424Free PMC Article
Cisplatin-based chemotherapy for advanced seminoma: report of 52 cases treated in two institutions.
Giannis M, Aristotelis B, Vassiliki K, Ioannis A, Konstantinos S, Nikolaos A, Georgios P, Georgios P, Pantelis P, Meletios-Athanasios D
J Cancer Res Clin Oncol 2009 Nov;135(11):1495-500. Epub 2009 May 13 doi: 10.1007/s00432-009-0596-2. PMID: 19437039
Extragonadal seminoma: an international multicenter analysis of prognostic factors and long term treatment outcome.
Bokemeyer C, Droz JP, Horwich A, Gerl A, Fossa SD, Beyer J, Pont J, Schmoll HJ, Kanz L, Einhorn L, Nichols CR, Hartmann JT
Cancer 2001 Apr 1;91(7):1394-401. PMID: 11283942
Salvage chemotherapy with vinblastine, ifosfamide, and cisplatin in recurrent seminoma.
Miller KD, Loehrer PJ, Gonin R, Einhorn LH
J Clin Oncol 1997 Apr;15(4):1427-31. doi: 10.1200/JCO.1997.15.4.1427. PMID: 9193335
The treatment of extragonadal seminoma.
Jain KK, Bosl GJ, Bains MS, Whitmore WF, Golbey RB
J Clin Oncol 1984 Jul;2(7):820-7. doi: 10.1200/JCO.1984.2.7.820. PMID: 6204019

Prognosis

Primary retroperitoneal seminoma - embryology, histopathology and treatment particularities.
Gîngu CV, Mihai M, Baston C, Crăsneanu MA, Dick AV, Olaru V, Sinescu I
Rom J Morphol Embryol 2016;57(3):1045-1050. PMID: 28002522
Laboratory markers and germ cell tumors.
von Eyben FE
Crit Rev Clin Lab Sci 2003 Aug;40(4):377-427. doi: 10.1080/10408360390247814. PMID: 14582602
Extragonadal seminoma: an international multicenter analysis of prognostic factors and long term treatment outcome.
Bokemeyer C, Droz JP, Horwich A, Gerl A, Fossa SD, Beyer J, Pont J, Schmoll HJ, Kanz L, Einhorn L, Nichols CR, Hartmann JT
Cancer 2001 Apr 1;91(7):1394-401. PMID: 11283942
Salvage chemotherapy with vinblastine, ifosfamide, and cisplatin in recurrent seminoma.
Miller KD, Loehrer PJ, Gonin R, Einhorn LH
J Clin Oncol 1997 Apr;15(4):1427-31. doi: 10.1200/JCO.1997.15.4.1427. PMID: 9193335
Extragonadal germ cell tumors. A 14-year Toronto experience.
Goss PE, Schwertfeger L, Blackstein ME, Iscoe NA, Ginsberg RJ, Simpson WJ, Jones DP, Shepherd FA
Cancer 1994 Apr 1;73(7):1971-9. doi: 10.1002/1097-0142(19940401)73:7<1971::aid-cncr2820730731>3.0.co;2-a. PMID: 8137224

Clinical prediction guides

Primary mediastinal and retroperitoneal malignant germ cell tumors in children and adolescents: Results of the TGM95 trial, a study of the French Society of Pediatric Oncology (Société Française des Cancers de l'Enfant).
Sudour-Bonnange H, Faure-Conter C, Martelli H, Hameury F, Fresneau B, Orbach D, Vérité C
Pediatr Blood Cancer 2017 Sep;64(9) Epub 2017 Mar 17 doi: 10.1002/pbc.26494. PMID: 28306215
Primary retroperitoneal seminoma - embryology, histopathology and treatment particularities.
Gîngu CV, Mihai M, Baston C, Crăsneanu MA, Dick AV, Olaru V, Sinescu I
Rom J Morphol Embryol 2016;57(3):1045-1050. PMID: 28002522
Clinical and biological significance of CXCL12 and CXCR4 expression in adult testes and germ cell tumours of adults and adolescents.
Gilbert DC, Chandler I, McIntyre A, Goddard NC, Gabe R, Huddart RA, Shipley J
J Pathol 2009 Jan;217(1):94-102. doi: 10.1002/path.2436. PMID: 18839394
Laboratory markers and germ cell tumors.
von Eyben FE
Crit Rev Clin Lab Sci 2003 Aug;40(4):377-427. doi: 10.1080/10408360390247814. PMID: 14582602
Extragonadal seminoma: an international multicenter analysis of prognostic factors and long term treatment outcome.
Bokemeyer C, Droz JP, Horwich A, Gerl A, Fossa SD, Beyer J, Pont J, Schmoll HJ, Kanz L, Einhorn L, Nichols CR, Hartmann JT
Cancer 2001 Apr 1;91(7):1394-401. PMID: 11283942

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