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Extragonadal germ cell cancer

MedGen UID:
235292
•Concept ID:
C1334581
•
Neoplastic Process
Synonyms: extragonadal germ cell cancer; extragonadal germ cell malignant tumor; extragonadal germ cell malignant tumour; extragonadal germ cell tumor, malignant; Malignant Extragonadal Germ Cell Tumor; malignant extragonadal germ cell tumor; malignant extragonadal germ cell tumour; Malignant Neoplasm of Extragonadal Germ Cell; malignant neoplasm of extragonadal germ cell; Malignant Neoplasm of the Extragonadal Germ Cell; malignant neoplasm of the extragonadal germ cell; Malignant Tumor of Extragonadal Germ Cell; malignant tumor of extragonadal germ cell; Malignant Tumor of the Extragonadal Germ Cell; malignant tumor of the extragonadal germ cell; malignant tumour of extragonadal germ cell; malignant tumour of the extragonadal germ cell; tumor of extragonadal germ cell; tumour of extragonadal germ cell
 
Monarch Initiative: MONDO:0003113

Definition

A malignant germ cell tumor that develops as a primary tumor in an anatomic site other than the testis or ovary. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExtragonadal germ cell cancer

Professional guidelines

PubMed

Treatment options for carcinoma in situ testis.
Mortensen MS, Gundgaard MG, Daugaard G
Int J Androl 2011 Aug;34(4 Pt 2):e32-6. Epub 2011 Jun 9 doi: 10.1111/j.1365-2605.2011.01178.x. PMID: 21651575
Treatment of germ cell cancer with two cycles of high-dose ifosfamide, carboplatin, and etoposide with autologous stem-cell support.
Margolin K, Doroshow JH, Ahn C, Hamasaki V, Leong L, Morgan R, Raschko J, Shibata S, Somlo G, Tetef M
J Clin Oncol 1996 Oct;14(10):2631-7. doi: 10.1200/JCO.1996.14.10.2631. PMID: 8874321
Treatment and surgical staging of testicular and primary extragonadal germ cell cancer.
Garnick MB, Canellos GP, Richie JP
JAMA 1983 Oct 7;250(13):1733-41. PMID: 6684188

Recent clinical studies

Etiology

Probability of metachronous testicular cancer in patients with biopsy-proven intratubular germ cell neoplasia depends on first-time treatment of germ cell cancer.
Brabrand S, Fosså SD, Cvancarova M, Axcrona U, Lehne G
J Clin Oncol 2012 Nov 10;30(32):4004-10. Epub 2012 Oct 15 doi: 10.1200/JCO.2011.40.8914. PMID: 23071246
Burden of testicular, paratesticular and extragonadal germ cell tumours in Europe.
Trama A, Mallone S, Nicolai N, Necchi A, Schaapveld M, Gietema J, Znaor A, Ardanaz E, Berrino F; RARECARE Working Group
Eur J Cancer 2012 Jan;48(2):159-69. Epub 2011 Dec 3 doi: 10.1016/j.ejca.2011.08.020. PMID: 22142457
Treatment options for carcinoma in situ testis.
Mortensen MS, Gundgaard MG, Daugaard G
Int J Androl 2011 Aug;34(4 Pt 2):e32-6. Epub 2011 Jun 9 doi: 10.1111/j.1365-2605.2011.01178.x. PMID: 21651575
Late-effects after treatment for germ-cell cancer with cisplatin, vinblastine, and bleomycin.
Hansen SW
Dan Med Bull 1992 Oct;39(5):391-9. PMID: 1385050
Treatment and surgical staging of testicular and primary extragonadal germ cell cancer.
Garnick MB, Canellos GP, Richie JP
JAMA 1983 Oct 7;250(13):1733-41. PMID: 6684188

Diagnosis

Probability of metachronous testicular cancer in patients with biopsy-proven intratubular germ cell neoplasia depends on first-time treatment of germ cell cancer.
Brabrand S, Fosså SD, Cvancarova M, Axcrona U, Lehne G
J Clin Oncol 2012 Nov 10;30(32):4004-10. Epub 2012 Oct 15 doi: 10.1200/JCO.2011.40.8914. PMID: 23071246
Burden of testicular, paratesticular and extragonadal germ cell tumours in Europe.
Trama A, Mallone S, Nicolai N, Necchi A, Schaapveld M, Gietema J, Znaor A, Ardanaz E, Berrino F; RARECARE Working Group
Eur J Cancer 2012 Jan;48(2):159-69. Epub 2011 Dec 3 doi: 10.1016/j.ejca.2011.08.020. PMID: 22142457
Treatment options for carcinoma in situ testis.
Mortensen MS, Gundgaard MG, Daugaard G
Int J Androl 2011 Aug;34(4 Pt 2):e32-6. Epub 2011 Jun 9 doi: 10.1111/j.1365-2605.2011.01178.x. PMID: 21651575
Successful treatment of disseminated extragonadal germ cell cancer with intensive conventional chemotherapy after first-line high-dose chemotherapy.
Yuasa T, Yoshida T, Wakabayashi Y, Kataoka A, Narita M, Yoshiki T, Okada Y
Int J Clin Oncol 2006 Feb;11(1):60-3. doi: 10.1007/s10147-005-0530-9. PMID: 16508731
The unrecognized extragonadal germ cell cancer syndrome.
Richardson RL, Schoumacher RA, Fer MF, Hande KR, Forbes JT, Oldham RK, Greco FA
Ann Intern Med 1981 Feb;94(2):181-6. doi: 10.7326/0003-4819-94-2-181. PMID: 6162409

Therapy

Probability of metachronous testicular cancer in patients with biopsy-proven intratubular germ cell neoplasia depends on first-time treatment of germ cell cancer.
Brabrand S, Fosså SD, Cvancarova M, Axcrona U, Lehne G
J Clin Oncol 2012 Nov 10;30(32):4004-10. Epub 2012 Oct 15 doi: 10.1200/JCO.2011.40.8914. PMID: 23071246
Successful treatment of disseminated extragonadal germ cell cancer with intensive conventional chemotherapy after first-line high-dose chemotherapy.
Yuasa T, Yoshida T, Wakabayashi Y, Kataoka A, Narita M, Yoshiki T, Okada Y
Int J Clin Oncol 2006 Feb;11(1):60-3. doi: 10.1007/s10147-005-0530-9. PMID: 16508731
Late-effects after treatment for germ-cell cancer with cisplatin, vinblastine, and bleomycin.
Hansen SW
Dan Med Bull 1992 Oct;39(5):391-9. PMID: 1385050
Treatment and surgical staging of testicular and primary extragonadal germ cell cancer.
Garnick MB, Canellos GP, Richie JP
JAMA 1983 Oct 7;250(13):1733-41. PMID: 6684188
Chemotherapy of refractory germ cell cancer with Etoposide.
Lederman GS, Garnick MB, Canellos GP, Richie JP
J Clin Oncol 1983 Nov;1(11):706-9. doi: 10.1200/JCO.1983.1.11.706. PMID: 6321675

Prognosis

Probability of metachronous testicular cancer in patients with biopsy-proven intratubular germ cell neoplasia depends on first-time treatment of germ cell cancer.
Brabrand S, Fosså SD, Cvancarova M, Axcrona U, Lehne G
J Clin Oncol 2012 Nov 10;30(32):4004-10. Epub 2012 Oct 15 doi: 10.1200/JCO.2011.40.8914. PMID: 23071246
Burden of testicular, paratesticular and extragonadal germ cell tumours in Europe.
Trama A, Mallone S, Nicolai N, Necchi A, Schaapveld M, Gietema J, Znaor A, Ardanaz E, Berrino F; RARECARE Working Group
Eur J Cancer 2012 Jan;48(2):159-69. Epub 2011 Dec 3 doi: 10.1016/j.ejca.2011.08.020. PMID: 22142457
Late-effects after treatment for germ-cell cancer with cisplatin, vinblastine, and bleomycin.
Hansen SW
Dan Med Bull 1992 Oct;39(5):391-9. PMID: 1385050
Treatment and surgical staging of testicular and primary extragonadal germ cell cancer.
Garnick MB, Canellos GP, Richie JP
JAMA 1983 Oct 7;250(13):1733-41. PMID: 6684188
Idiopathic thrombocytopenia in association with extragonadal germ cell cancer.
Garnick MB, Griffin JD
Ann Intern Med 1983 Jun;98(6):926-7. doi: 10.7326/0003-4819-98-6-926. PMID: 6305246

Clinical prediction guides

Cancer of unknown primary patients with midline nodal distribution: midway between poor and favourable prognosis?
Pentheroudakis G, Stoyianni A, Pavlidis N
Cancer Treat Rev 2011 Apr;37(2):120-6. Epub 2010 Jul 31 doi: 10.1016/j.ctrv.2010.06.003. PMID: 20673701
Late-effects after treatment for germ-cell cancer with cisplatin, vinblastine, and bleomycin.
Hansen SW
Dan Med Bull 1992 Oct;39(5):391-9. PMID: 1385050

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