Ncoa1 nuclear receptor coactivator 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ncoa1provided by RGD
Official Full Name: nuclear receptor coactivator 1provided by RGD
Primary source: RGD:1309046
See related: Ensembl:ENSRNOG00000004068 AllianceGenome:RGD:1309046
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SRC-1
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and nuclear receptor binding activity. Involved in several processes, including animal organ development; estrous cycle; and mating behavior. Located in cytoplasm; neuron projection; and nucleus. Biomarker of hypothyroidism. Orthologous to human NCOA1 (nuclear receptor coactivator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 119.9), Brain (RPKM 115.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q14

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (32952090..33229829, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (27232609..27507992, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (28677563..28931844, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reduced levels of endogenous SRC-1 and apoA-IV expression are responsible for the impaired E2's anorectic action in obese females.
Title: Silencing steroid receptor coactivator-1 in the nucleus of the solitary tract reduces estrogenic effects on feeding and apolipoprotein A-IV expression.
In post-traumatic avoiders, predator-odor exposure led to lower SRC-1 expression in paraventricular nucleus and central amygdala, and higher expression in the ventral hippocampus.
Title: Post-traumatic stress avoidance is attenuated by corticosterone and associated with brain levels of steroid receptor co-activator-1 in rats.
results provided the first evidence that SRC-1 mediated endogenous estrogen regulation of hippocampal synaptic plasticity by targeting the expression of synaptic protein PSD-95
Title: Steroid receptor coactivator-1 mediates letrozole induced downregulation of postsynaptic protein PSD-95 in the hippocampus of adult female rats.
Age-related decrease of SRC-1 in specific motor, learning, and memory nuclei suggests its potential roles in neurodegenerative disorders, which may be one of the underlying mechanisms of the vulnerability of the aged brain.
Title: Alterations of steroid receptor coactivator-1 (SRC-1) immunoreactivities in specific brain regions of young and middle-aged female Sprague-Dawley rats.
Results showed that hippocampal SRC-1 is regulated by postnatal development but not ovariectomy.
Title: Expression of steroid receptor coactivator-1 was regulated by postnatal development but not ovariectomy in the hippocampus of rats.
Age-induced loss of PPARgamma/steroid receptor coactivator-1 interactions increased the binding of PPARgamma to the promoter of the adipogenic gene aP2.
Title: Aging alters PPARgamma in rodent and human adipose tissue by modulating the balance in steroid receptor coactivator-1.
interactions of SRC-1 from brain with progestin and estrogen receptors are dependent on ligand, receptor subtype, and brain region to manifest the pleiotropic functional consequences that underlie steroid-regulated behaviors
Title: Steroid receptor coactivator-1 from brain physically interacts differentially with steroid receptor subtypes.
the effects of colchicine (COL) and/or all-trans retinoic acid (ATRA) on expression of rexinoid receptors (RXRs) (alpha, beta, gamma), thyroid hormone receptor alpha and coregulators N-CoR, SMRT and SRC-1 mRNA in primary rat hepatocytes was investigated.
Title: The effect of all-trans retinoic acid and/or colchicine on expression of rexinoid and thyroid hormone nuclear receptors and their coregulators in primary rat hepatocytes.
These results support a model where VDR preferentially recruits SRC-1 to enhance bone-specific OC gene transcription.
Title: 1alpha,25-dihydroxy vitamin D3-enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1alpha,25-dihydroxy vitamin D3 receptor-SRC-1 coactivator complex.
Infusion of antisense oligodeoxynucleotides to SRC-1 mRNA into the VMN decreased estrogen receptor-dependent lordosis intensity and reduced progesterone receptor-dependent ear wiggling and hopping and darting.
Title: Nuclear receptor coactivators function in estrogen receptor- and progestin receptor-dependent aspects of sexual behavior in female rats.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6Got21 (e-PCR)
- UniSTS:115491

RH80592 (e-PCR)
- UniSTS:84302

AU046409 (e-PCR)
- UniSTS:111468

RH137721 (e-PCR)
- UniSTS:219808

D6Rat171 (e-PCR), detects polymorphism
- UniSTS:228009

D6Got18 (e-PCR)
- UniSTS:113840

D6Got22 (e-PCR)
- UniSTS:113596

D6Rat89 (e-PCR), detects polymorphism
- UniSTS:228080

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables nuclear retinoic acid receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear retinoid X receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to Thyroglobulin triiodothyronine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to hormone stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in estrous cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in hypothalamus development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within labyrinthine layer morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in lactation	IEP Inferred from Expression Pattern more info	PubMed
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in male mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of female receptivity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription from RNA polymerase II promoter by galactose	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of thyroid hormone mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to retinoic acid	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear receptor coactivator 1

Names: steroid receptor coactivator 1

NP_001382498.1

EC 2.3.1.48

XP_017449617.1

EC 2.3.1.48

XP_038968105.1

EC 2.3.1.48

XP_038968106.1

EC 2.3.1.48

XP_038968107.1

EC 2.3.1.48

XP_038968108.1

EC 2.3.1.48

XP_038968110.1

EC 2.3.1.48

XP_038968112.1

EC 2.3.1.48

XP_063117945.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395569.2 → NP_001382498.1 nuclear receptor coactivator 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6APA0, A6HAH8

Conserved Domains (9) summary

cd00130
Location:120 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam09606
Location:995 → 1362

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18948
Location:27 → 87

bHLH-PAS_NCoA1_SRC1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins

pfam07469
Location:1152 → 1208

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:927 → 972

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:633 → 709

SRC-1; Steroid receptor coactivator

pfam14598
Location:260 → 370

PAS_11; PAS domain

pfam16279
Location:744 → 821

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:469 → 591

NCOA_u2; Unstructured region on nuclear receptor coactivator protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

32952090..33229829 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112177.2 → XP_038968105.1 nuclear receptor coactivator 1 isoform X1

UniProtKB/TrEMBL

A0A8I6APA0, A0A8I6GLM3

Conserved Domains (9) summary

cd00130
Location:120 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam09606
Location:995 → 1362

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18948
Location:27 → 87

bHLH-PAS_NCoA1_SRC1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins

pfam07469
Location:1152 → 1208

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:927 → 972

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:633 → 709

SRC-1; Steroid receptor coactivator

pfam14598
Location:260 → 370

PAS_11; PAS domain

pfam16279
Location:744 → 821

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:469 → 591

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
XM_039112179.2 → XP_038968107.1 nuclear receptor coactivator 1 isoform X1

UniProtKB/TrEMBL

A0A8I6APA0, A0A8I6GLM3

Conserved Domains (9) summary

cd00130
Location:120 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam09606
Location:995 → 1362

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18948
Location:27 → 87

bHLH-PAS_NCoA1_SRC1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins

pfam07469
Location:1152 → 1208

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:927 → 972

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:633 → 709

SRC-1; Steroid receptor coactivator

pfam14598
Location:260 → 370

PAS_11; PAS domain

pfam16279
Location:744 → 821

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:469 → 591

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
XM_039112182.2 → XP_038968110.1 nuclear receptor coactivator 1 isoform X2

UniProtKB/TrEMBL

A0A8I6APA0

Conserved Domains (9) summary

cd00130
Location:120 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam09606
Location:995 → 1362

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18948
Location:27 → 87

bHLH-PAS_NCoA1_SRC1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins

pfam07469
Location:1152 → 1208

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:927 → 972

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:633 → 709

SRC-1; Steroid receptor coactivator

pfam14598
Location:260 → 370

PAS_11; PAS domain

pfam16279
Location:744 → 821

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:469 → 591

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
XM_039112180.2 → XP_038968108.1 nuclear receptor coactivator 1 isoform X1

UniProtKB/TrEMBL

A0A8I6APA0, A0A8I6GLM3

Conserved Domains (9) summary

cd00130
Location:120 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam09606
Location:995 → 1362

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18948
Location:27 → 87

bHLH-PAS_NCoA1_SRC1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins

pfam07469
Location:1152 → 1208

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:927 → 972

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:633 → 709

SRC-1; Steroid receptor coactivator

pfam14598
Location:260 → 370

PAS_11; PAS domain

pfam16279
Location:744 → 821

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:469 → 591

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
XM_063261875.1 → XP_063117945.1 nuclear receptor coactivator 1 isoform X1

UniProtKB/TrEMBL

A0A8I6GLM3
XM_017594128.3 → XP_017449617.1 nuclear receptor coactivator 1 isoform X1

UniProtKB/TrEMBL

A0A8I6APA0, A0A8I6GLM3

Related

ENSRNOP00000095436.1

Conserved Domains (9) summary

cd00130
Location:120 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam09606
Location:995 → 1362

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18948
Location:27 → 87

bHLH-PAS_NCoA1_SRC1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins

pfam07469
Location:1152 → 1208

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:927 → 972

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:633 → 709

SRC-1; Steroid receptor coactivator

pfam14598
Location:260 → 370

PAS_11; PAS domain

pfam16279
Location:744 → 821

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:469 → 591

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
XM_039112178.2 → XP_038968106.1 nuclear receptor coactivator 1 isoform X1

UniProtKB/TrEMBL

A0A8I6APA0, A0A8I6GLM3

Conserved Domains (9) summary

cd00130
Location:120 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam09606
Location:995 → 1362

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18948
Location:27 → 87

bHLH-PAS_NCoA1_SRC1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins

pfam07469
Location:1152 → 1208

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:927 → 972

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:633 → 709

SRC-1; Steroid receptor coactivator

pfam14598
Location:260 → 370

PAS_11; PAS domain

pfam16279
Location:744 → 821

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:469 → 591

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
XM_039112184.2 → XP_038968112.1 nuclear receptor coactivator 1 isoform X3

UniProtKB/TrEMBL

A0A8I6APA0, A6HAH8

Conserved Domains (9) summary

cd00130
Location:120 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam09606
Location:995 → 1362

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18948
Location:27 → 87

bHLH-PAS_NCoA1_SRC1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins

pfam07469
Location:1152 → 1208

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:927 → 972

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:633 → 709

SRC-1; Steroid receptor coactivator

pfam14598
Location:260 → 370

PAS_11; PAS domain

pfam16279
Location:744 → 821

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:469 → 591

NCOA_u2; Unstructured region on nuclear receptor coactivator protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001108012.1: Suppressed sequence

Description

NM_001108012.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.