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Verrucous Lesion

MedGen UID:
12134
•Concept ID:
C0043037
•
Neoplastic Process
Synonym: Verrucous lesions

Definition

A papillomavirus related epithelial overgrowth. It can be located anywhere on the body though when it involves the perineal region it is generally referred to as condyloma acuminatum. [from NCI]

Professional guidelines

PubMed

Guideline for the diagnosis, treatment and long-term management of cutaneous lupus erythematosus.
Lu Q, Long H, Chow S, Hidayat S, Danarti R, Listiawan Y, Deng D, Guo Q, Fang H, Tao J, Zhao M, Xiang L, Che N, Li F, Zhao H, Lau CS, Ip FC, Ho KM, Paliza AC, Vicheth C, Godse K, Cho S, Seow CS, Miyachi Y, Khang TH, Ungpakorn R, Galadari H, Shah R, Yang K, Zhou Y, Selmi C, Sawalha AH, Zhang X, Chen Y, Lin CS
J Autoimmun 2021 Sep;123:102707. Epub 2021 Aug 5 doi: 10.1016/j.jaut.2021.102707. PMID: 34364171
Management of oral potentially malignant disorders.
Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Proliferative verrucous leukoplakia: diagnosis, management and current advances.
Capella DL, Gonçalves JM, Abrantes AAA, Grando LJ, Daniel FI
Braz J Otorhinolaryngol 2017 Sep-Oct;83(5):585-593. Epub 2017 Jan 24 doi: 10.1016/j.bjorl.2016.12.005. PMID: 28209441Free PMC Article

Recent clinical studies

Etiology

Vulvar and perineal verrucous changes complicating hidradenitis suppurativa after wide excision: a case and literature review.
Ward RA, Udechukwu NS, Selim MA, Jaleel T
Dermatol Online J 2020 Jun 15;26(7) PMID: 32898403
Proliferating Onychomatricoma. Clinical, Dermoscopical, and Pathologic Features of Onychomatricoma New Variant Resembling Onycholemmal/Squamous Cell Carcinoma.
Perrin C, Ambrosetti D, Balme B, Thomas L
Am J Dermatopathol 2020 Nov;42(11):827-834. doi: 10.1097/DAD.0000000000001648. PMID: 32271204
Clinico-morphological features of BRAF inhibition-induced proliferative skin lesions in cancer patients.
Belum VR, Rosen AC, Jaimes N, Dranitsaris G, Pulitzer MP, Busam KJ, Marghoob AA, Carvajal RD, Chapman PB, Lacouture ME
Cancer 2015 Jan 1;121(1):60-8. Epub 2014 Sep 3 doi: 10.1002/cncr.28980. PMID: 25186461
Verrucous carcinoma of the tongue.
Vilela FA, Trope BM, Gurfinkel PC, Piñeiro-Maceira JM, Ramos-e-Silva M
Skinmed 2012 May-Jun;10(3):188-90. PMID: 22779105
A clinicopathological study on verrucous hyperplasia and verrucous carcinoma of the oral mucosa.
Zhu LK, Ding YW, Liu W, Zhou YM, Shi LJ, Zhou ZT
J Oral Pathol Med 2012 Feb;41(2):131-5. Epub 2011 Sep 13 doi: 10.1111/j.1600-0714.2011.01078.x. PMID: 21913992

Diagnosis

Vulvar and perineal verrucous changes complicating hidradenitis suppurativa after wide excision: a case and literature review.
Ward RA, Udechukwu NS, Selim MA, Jaleel T
Dermatol Online J 2020 Jun 15;26(7) PMID: 32898403
Oral Acyclovir in the Treatment of Verruca.
Bagwell A, Loy A, McFarland MS, Tessmer-Neubauer A
J Drugs Dermatol 2016 Feb;15(2):237-8. PMID: 26885794
Clinico-morphological features of BRAF inhibition-induced proliferative skin lesions in cancer patients.
Belum VR, Rosen AC, Jaimes N, Dranitsaris G, Pulitzer MP, Busam KJ, Marghoob AA, Carvajal RD, Chapman PB, Lacouture ME
Cancer 2015 Jan 1;121(1):60-8. Epub 2014 Sep 3 doi: 10.1002/cncr.28980. PMID: 25186461
Recalcitrant verrucous lesion: verrucous hyperplasia or epithelioma cuniculatum (verrucous carcinoma).
Kelishadi SS, Wirth GA, Evans GR
J Am Podiatr Med Assoc 2006 Mar-Apr;96(2):148-53. doi: 10.7547/0960148. PMID: 16546953
Chromoblastomycosis.
Vijaya D, Kumar BH
Mycoses 2005 Jan;48(1):82-4. doi: 10.1111/j.1439-0507.2004.01060.x. PMID: 15679674

Therapy

Vulvar and perineal verrucous changes complicating hidradenitis suppurativa after wide excision: a case and literature review.
Ward RA, Udechukwu NS, Selim MA, Jaleel T
Dermatol Online J 2020 Jun 15;26(7) PMID: 32898403
Oral Acyclovir in the Treatment of Verruca.
Bagwell A, Loy A, McFarland MS, Tessmer-Neubauer A
J Drugs Dermatol 2016 Feb;15(2):237-8. PMID: 26885794
Clinico-morphological features of BRAF inhibition-induced proliferative skin lesions in cancer patients.
Belum VR, Rosen AC, Jaimes N, Dranitsaris G, Pulitzer MP, Busam KJ, Marghoob AA, Carvajal RD, Chapman PB, Lacouture ME
Cancer 2015 Jan 1;121(1):60-8. Epub 2014 Sep 3 doi: 10.1002/cncr.28980. PMID: 25186461
Aquarium-borne Mycobacterium marinum skin infection. Report of 15 cases and review of the literature.
Bonamonte D, De Vito D, Vestita M, Delvecchio S, Ranieri LD, Santantonio M, Angelini G
Eur J Dermatol 2013 Jul-Aug;23(4):510-6. doi: 10.1684/ejd.2013.2103. PMID: 24002023
Recalcitrant verrucous lesion: verrucous hyperplasia or epithelioma cuniculatum (verrucous carcinoma).
Kelishadi SS, Wirth GA, Evans GR
J Am Podiatr Med Assoc 2006 Mar-Apr;96(2):148-53. doi: 10.7547/0960148. PMID: 16546953

Prognosis

Oral Acyclovir in the Treatment of Verruca.
Bagwell A, Loy A, McFarland MS, Tessmer-Neubauer A
J Drugs Dermatol 2016 Feb;15(2):237-8. PMID: 26885794
Cutaneous Chromoblastomycosis Mimicking Tuberculosis Verrucosa Cutis: Look for Copper Pennies!
Bandyopadhyay A, Majumdar K, Gangopadhyay M, Banerjee S
Turk Patoloji Derg 2015;31(3):223-5. doi: 10.5146/tjpath.2013.01197. PMID: 24272932
Buschke-Löwenstein tumor in childhood: a case report.
Ambriz-González G, Escobedo-Zavala LC, Carrillo de la Mora F, Ortiz-Arriaga A, Cordero-Zamora A, Corona-Nakamura A, López Ramírez MK, Velázquez Ramírez GA
J Pediatr Surg 2005 Sep;40(9):e25-7. doi: 10.1016/j.jpedsurg.2005.05.070. PMID: 16150329
A case of cutaneous ganglioneuroma developing within a lesion of seborrheic keratosis.
Ohno S, Horiguchi Y, Shintaku M
J Dermatol 2002 May;29(5):300-4. doi: 10.1111/j.1346-8138.2002.tb00267.x. PMID: 12081162
Verrucous lesion in patients with discoid lupus erythematosus. Clinical, histopathological and immunofluorescence studies.
Uitto J, Santa-Cruz DJ, Eisen AZ, Leone P
Br J Dermatol 1978 May;98(5):507-20. doi: 10.1111/j.1365-2133.1978.tb01936.x. PMID: 350258

Clinical prediction guides

Vulvar and perineal verrucous changes complicating hidradenitis suppurativa after wide excision: a case and literature review.
Ward RA, Udechukwu NS, Selim MA, Jaleel T
Dermatol Online J 2020 Jun 15;26(7) PMID: 32898403
Correlation of serum lactate dehydrogenase and alkaline phosphatase in different histological grades of head and neck squamous cell carcinoma and premalignant lesions.
Bhattacharjee A, Giri S, Roy M, Chakraborty A
J Cancer Res Ther 2018 Jul-Sep;14(5):934-940. doi: 10.4103/0973-1482.172718. PMID: 30197328
Verruciform Genital-Associated (Vegas) Xanthoma: report of a patient with verruciform xanthoma of the scrotum and literature review.
Beutler BD, Cohen PR
Dermatol Online J 2015 Aug 15;21(8) PMID: 26437158
Cutaneous Chromoblastomycosis Mimicking Tuberculosis Verrucosa Cutis: Look for Copper Pennies!
Bandyopadhyay A, Majumdar K, Gangopadhyay M, Banerjee S
Turk Patoloji Derg 2015;31(3):223-5. doi: 10.5146/tjpath.2013.01197. PMID: 24272932
Positive association of glucose-regulated protein 78 during oral cancer progression and the prognostic value in oral precancerous lesions.
Lin CY, Chen WH, Liao CT, Chen IH, Chiu CC, Wang HM, Yen TC, Lee LY, Chang JT, Cheng AJ
Head Neck 2010 Aug;32(8):1028-39. doi: 10.1002/hed.21287. PMID: 19953611

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