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Sarcomatoid mesothelioma

MedGen UID:
137774
•Concept ID:
C0334513
•
Neoplastic Process
Synonyms: Fibrous mesothelioma; Fibrous mesothelioma, malignant; malignant fibrous mesothelioma; malignant fibrous mesothelioma (morphologic abnormality); Sarcomatoid Mesothelioma; sarcomatoid mesothelioma; sarcomatoid mesothelioma (morphologic abnormality); Spindled mesothelioma; spindled mesothelioma
SNOMED CT: Sarcomatoid mesothelioma (399477001); Spindled mesothelioma (399477001); Fibrous mesothelioma, malignant (54443001); Fibrous mesothelioma (54443001)
 
Monarch Initiative: MONDO:0006407

Definition

A malignant neoplasm arising from mesothelial cells. It is characterized by the presence of spindle cells. Anaplastic morphologic features and multinucleated malignant cells may also be seen. [from NCI]

Professional guidelines

PubMed

Pathohistological diagnosis and differential diagnosis.
Tischoff I, Neid M, Neumann V, Tannapfel A
Recent Results Cancer Res 2011;189:57-78. doi: 10.1007/978-3-642-10862-4_5. PMID: 21479896
Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group.
Husain AN, Colby TV, Ordóñez NG, Krausz T, Borczuk A, Cagle PT, Chirieac LR, Churg A, Galateau-Salle F, Gibbs AR, Gown AM, Hammar SP, Litzky LA, Roggli VL, Travis WD, Wick MR
Arch Pathol Lab Med 2009 Aug;133(8):1317-31. doi: 10.5858/133.8.1317. PMID: 19653732
Differential diagnosis of sarcomatoid mesothelioma from true sarcoma and sarcomatoid carcinoma using immunohistochemistry.
Kushitani K, Takeshima Y, Amatya VJ, Furonaka O, Sakatani A, Inai K
Pathol Int 2008 Feb;58(2):75-83. doi: 10.1111/j.1440-1827.2007.02193.x. PMID: 18199156

Recent clinical studies

Etiology

Asbestos-induced mesothelial injury and carcinogenesis: Involvement of iron and reactive oxygen species.
Okazaki Y
Pathol Int 2022 Feb;72(2):83-95. Epub 2021 Dec 29 doi: 10.1111/pin.13196. PMID: 34965001
Spindle cell tumors of the pleura and the peritoneum: pathologic diagnosis and updates.
Boyraz B, Hung YP
APMIS 2022 Mar;130(3):140-154. Epub 2022 Jan 11 doi: 10.1111/apm.13203. PMID: 34942046
B7-H1 expression in malignant pleural mesothelioma is associated with sarcomatoid histology and poor prognosis.
Mansfield AS, Roden AC, Peikert T, Sheinin YM, Harrington SM, Krco CJ, Dong H, Kwon ED
J Thorac Oncol 2014 Jul;9(7):1036-1040. doi: 10.1097/JTO.0000000000000177. PMID: 24926549Free PMC Article
Pathohistological diagnosis and differential diagnosis.
Tischoff I, Neid M, Neumann V, Tannapfel A
Recent Results Cancer Res 2011;189:57-78. doi: 10.1007/978-3-642-10862-4_5. PMID: 21479896
Biomarkers for mesothelioma.
Scherpereel A, Lee YC
Curr Opin Pulm Med 2007 Jul;13(4):339-443. doi: 10.1097/MCP.0b013e32812144bb. PMID: 17534183

Diagnosis

Sarcoma of the Lung and Mediastinum.
Yoshida KI, Yoshida A
Surg Pathol Clin 2024 Jun;17(2):243-255. Epub 2023 Dec 15 doi: 10.1016/j.path.2023.11.008. PMID: 38692808
Sarcomatoid Mesothelioma: A Clinicopathological and Immunohistochemical Study of 64 Cases.
Oramas DM, Zaleski M, Moran CA
Int J Surg Pathol 2021 Dec;29(8):820-825. Epub 2021 May 3 doi: 10.1177/10668969211014256. PMID: 33939493
Revisiting localized malignant mesothelioma.
Mann S, Khawar S, Moran C, Kalhor N
Ann Diagn Pathol 2019 Apr;39:74-77. Epub 2019 Feb 19 doi: 10.1016/j.anndiagpath.2019.02.014. PMID: 30798074
Pathohistological diagnosis and differential diagnosis.
Tischoff I, Neid M, Neumann V, Tannapfel A
Recent Results Cancer Res 2011;189:57-78. doi: 10.1007/978-3-642-10862-4_5. PMID: 21479896
Biomarkers for mesothelioma.
Scherpereel A, Lee YC
Curr Opin Pulm Med 2007 Jul;13(4):339-443. doi: 10.1097/MCP.0b013e32812144bb. PMID: 17534183

Therapy

Tumor suppressor effect of an antibody on xenotransplanted sarcomatoid mesothelioma cells.
Hasegawa M, Hanamatsu Y, Saigo C, Kito Y, Takeuchi T
Thorac Cancer 2022 Sep;13(18):2566-2573. Epub 2022 Aug 2 doi: 10.1111/1759-7714.14591. PMID: 35916358Free PMC Article
Asbestos-induced mesothelial injury and carcinogenesis: Involvement of iron and reactive oxygen species.
Okazaki Y
Pathol Int 2022 Feb;72(2):83-95. Epub 2021 Dec 29 doi: 10.1111/pin.13196. PMID: 34965001
Heterologous sarcomatoid pleural mesothelioma with osteosarcomatous differentiation: a report of autopsy case that accomplished trimodality therapy and review of the literature.
Itano H, Takeda T, Yamada T, Koide M, Kobayashi T
Gen Thorac Cardiovasc Surg 2020 Aug;68(8):871-879. Epub 2019 Aug 1 doi: 10.1007/s11748-019-01182-8. PMID: 31372931
Revisiting localized malignant mesothelioma.
Mann S, Khawar S, Moran C, Kalhor N
Ann Diagn Pathol 2019 Apr;39:74-77. Epub 2019 Feb 19 doi: 10.1016/j.anndiagpath.2019.02.014. PMID: 30798074
Systematic review of response rates of sarcomatoid malignant pleural mesotheliomas in clinical trials.
Mansfield AS, Symanowski JT, Peikert T
Lung Cancer 2014 Nov;86(2):133-6. Epub 2014 Sep 1 doi: 10.1016/j.lungcan.2014.08.017. PMID: 25217189Free PMC Article

Prognosis

Spindle cell tumors of the pleura and the peritoneum: pathologic diagnosis and updates.
Boyraz B, Hung YP
APMIS 2022 Mar;130(3):140-154. Epub 2022 Jan 11 doi: 10.1111/apm.13203. PMID: 34942046
Revisiting localized malignant mesothelioma.
Mann S, Khawar S, Moran C, Kalhor N
Ann Diagn Pathol 2019 Apr;39:74-77. Epub 2019 Feb 19 doi: 10.1016/j.anndiagpath.2019.02.014. PMID: 30798074
B7-H1 expression in malignant pleural mesothelioma is associated with sarcomatoid histology and poor prognosis.
Mansfield AS, Roden AC, Peikert T, Sheinin YM, Harrington SM, Krco CJ, Dong H, Kwon ED
J Thorac Oncol 2014 Jul;9(7):1036-1040. doi: 10.1097/JTO.0000000000000177. PMID: 24926549Free PMC Article
Pathohistological diagnosis and differential diagnosis.
Tischoff I, Neid M, Neumann V, Tannapfel A
Recent Results Cancer Res 2011;189:57-78. doi: 10.1007/978-3-642-10862-4_5. PMID: 21479896
Biomarkers for mesothelioma.
Scherpereel A, Lee YC
Curr Opin Pulm Med 2007 Jul;13(4):339-443. doi: 10.1097/MCP.0b013e32812144bb. PMID: 17534183

Clinical prediction guides

Loss of Methylthioadenosine Phosphorylase by Immunohistochemistry Is Common in Pulmonary Sarcomatoid Carcinoma and Sarcomatoid Mesothelioma.
Terra S, Roden AC, Yi ES, Aubry MC, Boland JM
Am J Clin Pathol 2022 Jan 6;157(1):33-39. doi: 10.1093/ajcp/aqab091. PMID: 34463336
The 2015 World Health Organization Classification of Tumors of the Pleura: Advances since the 2004 Classification.
Galateau-Salle F, Churg A, Roggli V, Travis WD; World Health Organization Committee for Tumors of the Pleura
J Thorac Oncol 2016 Feb;11(2):142-54. doi: 10.1016/j.jtho.2015.11.005. PMID: 26811225
Sarcomatoid mesothelioma: future advances in diagnosis, biomolecular assessment, and therapeutic options in a poor-outcome disease.
Galetta D, Catino A, Misino A, Logroscino A, Fico M
Tumori 2016 Mar-Apr;102(2):127-30. Epub 2015 Jun 5 doi: 10.5301/tj.5000364. PMID: 26108245
Systematic review of response rates of sarcomatoid malignant pleural mesotheliomas in clinical trials.
Mansfield AS, Symanowski JT, Peikert T
Lung Cancer 2014 Nov;86(2):133-6. Epub 2014 Sep 1 doi: 10.1016/j.lungcan.2014.08.017. PMID: 25217189Free PMC Article
Biomarkers for mesothelioma.
Scherpereel A, Lee YC
Curr Opin Pulm Med 2007 Jul;13(4):339-443. doi: 10.1097/MCP.0b013e32812144bb. PMID: 17534183

Recent systematic reviews

Diagnostic performance of immunohistochemistry markers for malignant pleural mesothelioma diagnosis and subtypes. A systematic review and meta-analysis.
Parra-Medina R, Castañeda-González JP, Chaves-Cabezas V, Alzate JP, Chaves JJ
Pathol Res Pract 2024 May;257:155276. Epub 2024 Mar 30 doi: 10.1016/j.prp.2024.155276. PMID: 38603842
The differential diagnosis between pleural sarcomatoid mesothelioma and spindle cell/pleomorphic (sarcomatoid) carcinomas of the lung: evidence-based guidelines from the International Mesothelioma Panel and the MESOPATH National Reference Center.
Marchevsky AM, LeStang N, Hiroshima K, Pelosi G, Attanoos R, Churg A, Chirieac L, Dacic S, Husain A, Khoor A, Klebe S, Lantuejoul S, Roggli V, Vignaud JM, Weynard B, Sauter J, Henderson D, Nabeshima K, Galateau-Salle F
Hum Pathol 2017 Sep;67:160-168. Epub 2017 Aug 4 doi: 10.1016/j.humpath.2017.07.015. PMID: 28782639
Systematic review of response rates of sarcomatoid malignant pleural mesotheliomas in clinical trials.
Mansfield AS, Symanowski JT, Peikert T
Lung Cancer 2014 Nov;86(2):133-6. Epub 2014 Sep 1 doi: 10.1016/j.lungcan.2014.08.017. PMID: 25217189Free PMC Article

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