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Increased CD4:CD8 ratio

MedGen UID:: 1614673
•Concept ID:: C0920173
•: Finding

Synonyms:	Increased CD4+/CD8+ ratio; Increased CD4+:CD8+ ratio

HPO:	HP:0033221

Definition

An abnormal elevation of the relative proportion of CD4+ to CD8+ T cells. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVIncreased CD4:CD8 ratio

Abnormal leukocyte morphology
- Abnormal leukocyte count
  - Abnormal lymphocyte count
    - Abnormal T cell count
      - Abnormal T cell subset distribution
        Abnormal CD4:CD8 ratio
        Increased CD4:CD8 ratio

Conditions with this feature

Autoimmune disease, multisystem, infantile-onset, 2

MedGen UID:: 934735
•Concept ID:: C4310768
•: Disease or Syndrome

Any autoimmune disease, multisystem, infantile-onset in which the cause of the disease is a mutation in the ZAP70 gene.

See: Condition Record

Proteasome-associated autoinflammatory syndrome 2

MedGen UID:: 1648482
•Concept ID:: C4747989
•: Disease or Syndrome

Proteasome-associated autoinflammatory syndrome-2 (PRAAS2) is an autosomal dominant disorder with onset in early infancy. Affected individuals develop severe inflammatory neutrophilic dermatitis, autoimmunity, and variable immunodeficiency (summary by Poli et al., 2018). For a discussion of genetic heterogeneity of PRAAS, see PRAAS1 (256040).

See: Condition Record

Autoimmune disease, multisystem, infantile-onset, 2

Proteasome-associated autoinflammatory syndrome 2

Professional guidelines

PubMed

A retrospective clinical study of dolutegravir- versus efavirenz-based regimen in treatment-naïve patients with advanced HIV infection in Nanjing, China.

Zhong M, Li M, Qi M, Su Y, Yu N, Lv R, Ye Z, Zhang X, Xu X, Cheng C, Chen C, Wei H
Front Immunol 2022;13:1033098. Epub 2023 Jan 9 doi: 10.3389/fimmu.2022.1033098. PMID: 36700216 Free PMC Article

CD4/CD8 ratio improvement in HIV-1-infected patients receiving dual antiretroviral treatment.

Monsalvo M, Vallejo A, Fontecha M, Vivancos MJ, Vizcarra P, Casado JL
Int J STD AIDS 2019 Jun;30(7):656-662. Epub 2019 Apr 8 doi: 10.1177/0956462419834129. PMID: 30961467

Treatment response to dimethyl fumarate is characterized by disproportionate CD8+ T cell reduction in MS.

Fleischer V, Friedrich M, Rezk A, Bühler U, Witsch E, Uphaus T, Bittner S, Groppa S, Tackenberg B, Bar-Or A, Zipp F, Luessi F
Mult Scler 2018 Apr;24(5):632-641. Epub 2017 Apr 24 doi: 10.1177/1352458517703799. PMID: 28436295

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Recent clinical studies

Etiology

Probiotics to HIV-Infected Immunological Nonresponders: Altered Mucosal Immunity and Microbial Diversity Restricted to Ileum.

Meyer-Myklestad MH, Medhus AW, Stiksrud B, Lorvik KB, Seljeflot I, Hansen SH, Holm K, Hov JR, Kvale D, Dyrhol-Riise AM, Kummen M, Trøseid M, Reikvam DH
J Acquir Immune Defic Syndr 2022 Jan 1;89(1):77-86. doi: 10.1097/QAI.0000000000002817. PMID: 34878437

Increased CD4 : CD8 ratio normalization with implementation of current ART management guidelines.

Zhabokritsky A, Szadkowski L, Cooper C, Loutfy M, Wong A, McClean A, Hogg RS, Walmsley SL; Canadian Observational Cohort (CANOC) Collaboration
J Antimicrob Chemother 2021 Feb 11;76(3):729-737. doi: 10.1093/jac/dkaa484. PMID: 33249444 Free PMC Article

Immune Abnormalities in Patients With Single Ventricle Circulation Precede the Fontan Procedure.

Kovacikova L, Krasnanova V, Skrak P, Zahorec M, Kantorova A, Semberova J, Bacharova L
World J Pediatr Congenit Heart Surg 2017 Nov;8(6):672-682. doi: 10.1177/2150135117732529. PMID: 29187105

Effects of cyanocobalamin on immunity in patients with pernicious anemia.

Erkurt MA, Aydogdu I, Dikilitaş M, Kuku I, Kaya E, Bayraktar N, Ozhan O, Ozkan I, Sonmez A
Med Princ Pract 2008;17(2):131-5. Epub 2008 Feb 19 doi: 10.1159/000112967. PMID: 18287797

Pregranulomatous phase of sarcoidosis: immunohistochemical diagnosis.

Jaskiewicz K, Rzepko R, Dubaniewicz A, Jassem E, Raczynska K
Acta Histochem 2006;107(6):473-7. Epub 2005 Oct 26 doi: 10.1016/j.acthis.2005.09.003. PMID: 16256177

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Diagnosis

Relationships between T-lymphocytes and physical function in adults with chronic lymphocytic leukemia: Results from the HEALTH4CLL pilot study.

Crane JC, Gordon MJ, Basen-Engquist K, Ferrajoli A, Markofski MM, Lee CY, Fares S, Simpson RJ, LaVoy EC
Eur J Haematol 2023 Jun;110(6):732-742. Epub 2023 Mar 31 doi: 10.1111/ejh.13958. PMID: 36946440 Free PMC Article

Intravesical Pseudomonas aeruginosa mannose-sensitive Hemagglutinin vaccine triggers a tumor-preventing immune environment in an orthotopic mouse bladder cancer model.

Wang B, He Z, Yu H, Ou Z, Chen J, Yang M, Fan X, Lin T, Huang J
Cancer Immunol Immunother 2022 Jun;71(6):1507-1517. Epub 2021 Oct 31 doi: 10.1007/s00262-021-03063-7. PMID: 34718847 Free PMC Article

BAL fluid cells in newly diagnosed pulmonary sarcoidosis with different clinical activity.

Danila E, Jurgauskiene L, Norkuniene J, Malickaite R
Ups J Med Sci 2009;114(1):26-31. doi: 10.1080/03009730802579729. PMID: 19242869 Free PMC Article

Pregranulomatous phase of sarcoidosis: immunohistochemical diagnosis.

Jaskiewicz K, Rzepko R, Dubaniewicz A, Jassem E, Raczynska K
Acta Histochem 2006;107(6):473-7. Epub 2005 Oct 26 doi: 10.1016/j.acthis.2005.09.003. PMID: 16256177

Bronchoalveolar lavage in rheumatoid arthritis.

Kolarz G, Scherak O, Popp W, Ritschka L, Thumb N, Wottawa A, Zwick H
Br J Rheumatol 1993 Jul;32(7):556-61. doi: 10.1093/rheumatology/32.7.556. PMID: 8339125

See all (29)

Therapy

Probiotics to HIV-Infected Immunological Nonresponders: Altered Mucosal Immunity and Microbial Diversity Restricted to Ileum.

Intravesical Pseudomonas aeruginosa mannose-sensitive Hemagglutinin vaccine triggers a tumor-preventing immune environment in an orthotopic mouse bladder cancer model.

Wang B, He Z, Yu H, Ou Z, Chen J, Yang M, Fan X, Lin T, Huang J
Cancer Immunol Immunother 2022 Jun;71(6):1507-1517. Epub 2021 Oct 31 doi: 10.1007/s00262-021-03063-7. PMID: 34718847 Free PMC Article

Increased CD4 : CD8 ratio normalization with implementation of current ART management guidelines.

Effects of cyanocobalamin on immunity in patients with pernicious anemia.

Erkurt MA, Aydogdu I, Dikilitaş M, Kuku I, Kaya E, Bayraktar N, Ozhan O, Ozkan I, Sonmez A
Med Princ Pract 2008;17(2):131-5. Epub 2008 Feb 19 doi: 10.1159/000112967. PMID: 18287797

Can the CD4+/CD8+ ratio predict the outcome of interferon-alpha therapy for renal cell carcinoma?

Hernberg M, Muhonen T, Pyrhönen S
Ann Oncol 1997 Jan;8(1):71-7. doi: 10.1023/a:1008293117223. PMID: 9093710

See all (27)

Prognosis

Pulmonary sarcoid-like granulomatosis induced by nivolumab.

Montaudié H, Pradelli J, Passeron T, Lacour JP, Leroy S
Br J Dermatol 2017 Apr;176(4):1060-1063. Epub 2016 Dec 19 doi: 10.1111/bjd.14808. PMID: 27291635

Immune cells and prognosis in HPV-associated oropharyngeal squamous cell carcinomas: Review of the literature.

Saber CN, Grønhøj Larsen C, Dalianis T, von Buchwald C
Oral Oncol 2016 Jul;58:8-13. Epub 2016 May 7 doi: 10.1016/j.oraloncology.2016.04.004. PMID: 27311396

Changes in peripheral T-lymphocyte subsets in acute-on-chronic liver failure patients with artificial liver support system.

Lou YF, Dong W, Ye B, Lin S, Mao WL
Hepatogastroenterology 2012 May;59(115):814-7. doi: 10.5754/hge10064. PMID: 22469725

Unfavorable clinical implications of circulating CD44+ lymphocytes in patients with nasopharyngeal carcinoma undergoing radiochemotherapy.

Hu FJ, Ge MH, Li P, Wang CC, Ling YT, Mao WM, Ling ZQ
Clin Chim Acta 2012 Jan 18;413(1-2):213-8. Epub 2011 Sep 29 doi: 10.1016/j.cca.2011.09.026. PMID: 21983162

Can the CD4+/CD8+ ratio predict the outcome of interferon-alpha therapy for renal cell carcinoma?

Hernberg M, Muhonen T, Pyrhönen S
Ann Oncol 1997 Jan;8(1):71-7. doi: 10.1023/a:1008293117223. PMID: 9093710

See all (19)

Clinical prediction guides

Probiotics to HIV-Infected Immunological Nonresponders: Altered Mucosal Immunity and Microbial Diversity Restricted to Ileum.

Impact of switching to raltegravir and/or adding losartan in lymphoid tissue fibrosis and inflammation in people living with HIV. A randomized clinical trial.

Torres B, Guardo AC, Squarcia M, Diaz A, Fabra A, Caballero M, Ugarte A, Leal L, Gatell JM, Plana M, Garcia F
HIV Med 2021 Sep;22(8):674-681. Epub 2021 Jul 20 doi: 10.1111/hiv.13114. PMID: 34288357

Increased CD4 : CD8 ratio normalization with implementation of current ART management guidelines.

Immune Abnormalities in Patients With Single Ventricle Circulation Precede the Fontan Procedure.

Kovacikova L, Krasnanova V, Skrak P, Zahorec M, Kantorova A, Semberova J, Bacharova L
World J Pediatr Congenit Heart Surg 2017 Nov;8(6):672-682. doi: 10.1177/2150135117732529. PMID: 29187105

Common variants of T-cells contribute differently to phenotypic variation in sarcoidosis.

Rivera NV, Hagemann-Jensen M, Ferreira MAR, Kullberg S, Eklund A, Martin NG, Padyukov L, Grunewald J
Sci Rep 2017 Jul 17;7(1):5623. doi: 10.1038/s41598-017-05754-7. PMID: 28717140 Free PMC Article

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Recent systematic reviews

Aidi injection, a traditional Chinese biomedical preparation for gynecologic tumors: a systematic review and PRISMA-compliant meta-analysis.

Li X, Xiao C, Qu K
Biosci Rep 2021 Mar 26;41(3) doi: 10.1042/BSR20204457. PMID: 33624761 Free PMC Article

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MedGen

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Increased CD4:CD8 ratio

Definition

Term Hierarchy

Conditions with this feature

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

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