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Increased proportion of naive T cells

MedGen UID:
1618068
•Concept ID:
C4531151
•
Finding
Synonyms: Elevated proportion of naive T cells; Increased proportion of naive thymus-derived, alpha-beta T cells
 
HPO: HP:0031398

Definition

An abnormally increased proportion of naive T cells relative to the total number of T cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased proportion of naive T cells

Professional guidelines

PubMed

High-dimensional analysis of T-cell profiling variations following belimumab treatment in systemic lupus erythematosus.
Maeda S, Hashimoto H, Maeda T, Tamechika SY, Isogai S, Naniwa T, Niimi A
Lupus Sci Med 2023 Oct;10(2) doi: 10.1136/lupus-2023-000976. PMID: 37802602Free PMC Article
Vitiligo after alemtuzumab treatment: Secondary autoimmunity is not all about B cells.
Ruck T, Pfeuffer S, Schulte-Mecklenbeck A, Gross CC, Lindner M, Metze D, Ehrchen J, Sondermann W, Pul R, Kleinschnitz C, Wiendl H, Meuth SG, Klotz L
Neurology 2018 Dec 11;91(24):e2233-e2237. Epub 2018 Nov 7 doi: 10.1212/WNL.0000000000006648. PMID: 30404783Free PMC Article
Alemtuzumab for the treatment of relapsing-remitting multiple sclerosis.
Hersh CM, Cohen JA
Immunotherapy 2014;6(3):249-59. doi: 10.2217/imt.14.7. PMID: 24762071

Recent clinical studies

Etiology

Characteristics of premanufacture CD8(+)T cells determine CAR-T efficacy in patients with diffuse large B-cell lymphoma.
Wang Y, Tong C, Lu Y, Wu Z, Guo Y, Liu Y, Wei J, Wang C, Yang Q, Han W
Signal Transduct Target Ther 2023 Oct 25;8(1):409. doi: 10.1038/s41392-023-01659-2. PMID: 37875502Free PMC Article
Role of thymus in health and disease.
Gulla S, Reddy MC, Reddy VC, Chitta S, Bhanoori M, Lomada D
Int Rev Immunol 2023;42(5):347-363. Epub 2022 May 20 doi: 10.1080/08830185.2022.2064461. PMID: 35593192
Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations.
Rae W, Sowerby JM, Verhoeven D, Youssef M, Kotagiri P, Savinykh N, Coomber EL, Boneparth A, Chan A, Gong C, Jansen MH, du Long R, Santilli G, Simeoni I, Stephens J, Wu K, Zinicola M, Allen HL, Baxendale H, Kumararatne D, Gkrania-Klotsas E, Scheffler Mendoza SC, Yamazaki-Nakashimada MA, Ruiz LB, Rojas-Maruri CM, Lugo Reyes SO, Lyons PA, Williams AP, Hodson DJ, Bishop GA, Thrasher AJ, Thomas DC, Murphy MP, Vyse TJ, Milner JD, Kuijpers TW, Smith KGC
Sci Immunol 2022 Aug 12;7(74):eabn3800. doi: 10.1126/sciimmunol.abn3800. PMID: 35960817
Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma.
Verkleij CPM, Broekmans MEC, van Duin M, Frerichs KA, Kuiper R, de Jonge AV, Kaiser M, Morgan G, Axel A, Boominathan R, Sendecki J, Wong A, Verona RI, Sonneveld P, Zweegman S, Adams HC, Mutis T, van de Donk NWCJ
Blood Adv 2021 Apr 27;5(8):2196-2215. doi: 10.1182/bloodadvances.2020003805. PMID: 33890981Free PMC Article
Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt(+) Regulatory T Cells and Exacerbate Colitis in Mice.
Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ
Immunity 2019 Jan 15;50(1):212-224.e4. doi: 10.1016/j.immuni.2018.12.015. PMID: 30650377Free PMC Article

Diagnosis

Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus.
Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Identification of genes related to glucose metabolism and analysis of the immune characteristics in Alzheimer's disease.
Wang Y, Shen Z, Wu H, Yu Z, Wu X, Zhou L, Guo F
Brain Res 2023 Nov 15;1819:148545. Epub 2023 Aug 22 doi: 10.1016/j.brainres.2023.148545. PMID: 37619853
Role of thymus in health and disease.
Gulla S, Reddy MC, Reddy VC, Chitta S, Bhanoori M, Lomada D
Int Rev Immunol 2023;42(5):347-363. Epub 2022 May 20 doi: 10.1080/08830185.2022.2064461. PMID: 35593192
Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma.
Verkleij CPM, Broekmans MEC, van Duin M, Frerichs KA, Kuiper R, de Jonge AV, Kaiser M, Morgan G, Axel A, Boominathan R, Sendecki J, Wong A, Verona RI, Sonneveld P, Zweegman S, Adams HC, Mutis T, van de Donk NWCJ
Blood Adv 2021 Apr 27;5(8):2196-2215. doi: 10.1182/bloodadvances.2020003805. PMID: 33890981Free PMC Article
Immune Cell Landscape in Gastric Cancer.
Yang Y, He W, Wang ZR, Wang YJ, Li LL, Lu JZ, Tao Y, Zhang J, Fu SJ, Wang ZP, Liu SH
Biomed Res Int 2021;2021:1930706. Epub 2021 Jan 9 doi: 10.1155/2021/1930706. PMID: 33575321Free PMC Article

Therapy

Efficacy and Safety of Tofacitinib in Patients with Polymyalgia Rheumatica (EAST PMR): An open-label randomized controlled trial.
Ma X, Yang F, Wu J, Xu B, Jiang M, Sun Y, Sun C, Yu Y, Xu D, Xiao L, Ren C, Chen C, Ye Z, Liang J, Lin J, Chen W
PLoS Med 2023 Jun;20(6):e1004249. Epub 2023 Jun 29 doi: 10.1371/journal.pmed.1004249. PMID: 37384596Free PMC Article
SIRT3 Activator Honokiol Inhibits Th17 Cell Differentiation and Alleviates Colitis.
Chen X, Zhang M, Zhou F, Gu Z, Li Y, Yu T, Peng C, Zhou L, Li X, Zhu D, Zhang X, Yu C
Inflamm Bowel Dis 2023 Dec 5;29(12):1929-1940. doi: 10.1093/ibd/izad099. PMID: 37335900Free PMC Article
Systemic inflammation and cortical neurochemistry in never-medicated first episode-psychosis individuals.
León-Ortiz P, Rivera-Chávez LF, Torres-Ruíz J, Reyes-Madrigal F, Carrillo-Vázquez D, Moncada-Habib T, Cassiano-Quezada F, Cadenhead KS, Gómez-Martín D, de la Fuente-Sandoval C
Brain Behav Immun 2023 Jul;111:270-276. Epub 2023 May 5 doi: 10.1016/j.bbi.2023.05.001. PMID: 37149107Free PMC Article
Increased Percentage of CD8(+)CD28(-) Regulatory T Cells With Fingolimod Therapy in Multiple Sclerosis.
Houston TW, Howlett-Prieto Q, Regenauer C, Testai FD, Yao F, Feng X, Reder AT
Neurol Neuroimmunol Neuroinflamm 2023 Mar;10(2) Epub 2022 Dec 19 doi: 10.1212/NXI.0000000000200075. PMID: 36535763Free PMC Article
Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma.
Verkleij CPM, Broekmans MEC, van Duin M, Frerichs KA, Kuiper R, de Jonge AV, Kaiser M, Morgan G, Axel A, Boominathan R, Sendecki J, Wong A, Verona RI, Sonneveld P, Zweegman S, Adams HC, Mutis T, van de Donk NWCJ
Blood Adv 2021 Apr 27;5(8):2196-2215. doi: 10.1182/bloodadvances.2020003805. PMID: 33890981Free PMC Article

Prognosis

Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus.
Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Human immune phenotyping reveals accelerated aging in type 1 diabetes.
Shapiro MR, Dong X, Perry DJ, McNichols JM, Thirawatananond P, Posgai AL, Peters LD, Motwani K, Musca RS, Muir A, Concannon P, Jacobsen LM, Mathews CE, Wasserfall CH, Haller MJ, Schatz DA, Atkinson MA, Brusko MA, Bacher R, Brusko TM
JCI Insight 2023 Sep 8;8(17) doi: 10.1172/jci.insight.170767. PMID: 37498686Free PMC Article
Identification of evolutionary mechanisms of myelomatous effusion by single-cell RNA sequencing.
Sun Z, Ji J, Li Y, Cui Y, Fan L, Li J, Qu X
Blood Adv 2023 Aug 8;7(15):4148-4159. doi: 10.1182/bloodadvances.2022009477. PMID: 37276129Free PMC Article
T cell-intrinsic STING signaling promotes regulatory T cell induction and immunosuppression by upregulating FOXP3 transcription in cervical cancer.
Ni H, Zhang H, Li L, Huang H, Guo H, Zhang L, Li C, Xu JX, Nie CP, Li K, Zhang X, Xia X, Li J
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005151. PMID: 36126994Free PMC Article
Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt(+) Regulatory T Cells and Exacerbate Colitis in Mice.
Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ
Immunity 2019 Jan 15;50(1):212-224.e4. doi: 10.1016/j.immuni.2018.12.015. PMID: 30650377Free PMC Article

Clinical prediction guides

Identification of genes related to glucose metabolism and analysis of the immune characteristics in Alzheimer's disease.
Wang Y, Shen Z, Wu H, Yu Z, Wu X, Zhou L, Guo F
Brain Res 2023 Nov 15;1819:148545. Epub 2023 Aug 22 doi: 10.1016/j.brainres.2023.148545. PMID: 37619853
Human immune phenotyping reveals accelerated aging in type 1 diabetes.
Shapiro MR, Dong X, Perry DJ, McNichols JM, Thirawatananond P, Posgai AL, Peters LD, Motwani K, Musca RS, Muir A, Concannon P, Jacobsen LM, Mathews CE, Wasserfall CH, Haller MJ, Schatz DA, Atkinson MA, Brusko MA, Bacher R, Brusko TM
JCI Insight 2023 Sep 8;8(17) doi: 10.1172/jci.insight.170767. PMID: 37498686Free PMC Article
T cell-intrinsic STING signaling promotes regulatory T cell induction and immunosuppression by upregulating FOXP3 transcription in cervical cancer.
Ni H, Zhang H, Li L, Huang H, Guo H, Zhang L, Li C, Xu JX, Nie CP, Li K, Zhang X, Xia X, Li J
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005151. PMID: 36126994Free PMC Article
Age-associated B cells indicate disease activity in rheumatoid arthritis.
Bao W, Xie M, Ye Y
Cell Immunol 2022 Jul;377:104533. Epub 2022 May 6 doi: 10.1016/j.cellimm.2022.104533. PMID: 35594728
Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt(+) Regulatory T Cells and Exacerbate Colitis in Mice.
Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ
Immunity 2019 Jan 15;50(1):212-224.e4. doi: 10.1016/j.immuni.2018.12.015. PMID: 30650377Free PMC Article

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