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Locally Advanced Cervical Carcinoma

MedGen UID:
1654850
•Concept ID:
C4744723
•
Neoplastic Process

Definition

A cervical carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

Why brachytherapy boost is the treatment of choice for most women with locally advanced cervical carcinoma?
Al Feghali KA, Elshaikh MA
Brachytherapy 2016 Mar-Apr;15(2):191-9. Epub 2016 Feb 1 doi: 10.1016/j.brachy.2015.12.003. PMID: 26810408
Management of early and locally advanced cervical cancer.
Barbera L, Thomas G
Semin Oncol 2009 Apr;36(2):155-69. doi: 10.1053/j.seminoncol.2008.12.007. PMID: 19332250
Modern management of locally advanced cervical carcinoma.
Dueñas-Gonzalez A, Cetina L, Mariscal I, de la Garza J
Cancer Treat Rev 2003 Oct;29(5):389-99. doi: 10.1016/s0305-7372(03)00068-9. PMID: 12972357

Recent clinical studies

Etiology

Optimal cisplatin cycles in locally advanced cervical carcinoma patients treated with concurrent chemoradiotherapy.
Zeng Z, Wang W, Liu X, Wang G, Ren K, Zhang F, Hu K
Clin Transl Oncol 2023 Oct;25(10):2892-2900. Epub 2023 Apr 7 doi: 10.1007/s12094-023-03151-3. PMID: 37027060
Locally advanced cervical carcinoma patients treated with chemoradiation followed by radical surgery: clinical response and oncological outcomes according to histotype after propensity score analysis.
Legge F, Bizzarri N, Gallotta V, Pedone Anchora L, Cosentino F, Turco LC, Certelli C, Macchia G, Valentini V, Scambia G, Ferrandina G
Eur J Surg Oncol 2022 Sep;48(9):2045-2052. Epub 2022 Apr 12 doi: 10.1016/j.ejso.2022.04.004. PMID: 35450757
Neoadjuvant Chemotherapy in Locally Advanced Cervical Carcinoma - a Role in Patients with Para-aortic Lymph Node Involvement? A 10-year Institutional Experience.
Green HM, Counsell N, Ward A, McCormack M
Clin Oncol (R Coll Radiol) 2022 Jul;34(7):e281-e290. Epub 2022 Jan 6 doi: 10.1016/j.clon.2021.12.005. PMID: 35000828
Multimodality therapy for locally advanced cervical carcinoma: state of the art and future directions.
Monk BJ, Tewari KS, Koh WJ
J Clin Oncol 2007 Jul 10;25(20):2952-65. doi: 10.1200/JCO.2007.10.8324. PMID: 17617527
Modern management of locally advanced cervical carcinoma.
Dueñas-Gonzalez A, Cetina L, Mariscal I, de la Garza J
Cancer Treat Rev 2003 Oct;29(5):389-99. doi: 10.1016/s0305-7372(03)00068-9. PMID: 12972357

Diagnosis

Optimal cisplatin cycles in locally advanced cervical carcinoma patients treated with concurrent chemoradiotherapy.
Zeng Z, Wang W, Liu X, Wang G, Ren K, Zhang F, Hu K
Clin Transl Oncol 2023 Oct;25(10):2892-2900. Epub 2023 Apr 7 doi: 10.1007/s12094-023-03151-3. PMID: 37027060
Tumor histology is an independent prognostic factor in locally advanced cervical carcinoma: A retrospective study.
Gallardo-Alvarado L, Cantú-de León D, Ramirez-Morales R, Santiago-Concha G, Barquet-Muñoz S, Salcedo-Hernandez R, Reyes C, Perez-Alvarez S, Perez-Montiel D, Perez-Plasencia C, Trejo-Duran E, Galicia JP
BMC Cancer 2022 Apr 13;22(1):401. doi: 10.1186/s12885-022-09506-3. PMID: 35418030Free PMC Article
Mind the Gap Between Scientific Literature Recommendations and Effective Implementation. Is There Still a Role for Surgery in the Treatment of Locally Advanced Cervical Carcinoma?
Blidaru A, Bordea C, Burcoş T, Duduş L, Eniu D, Ioanid N, Kacso G, Minciuna C, Savu M, Scripcariu V, Tudor Ș, Vasilescu C, Voinea S
Chirurgia (Bucur) 2019 Jan-Feb;114(1):18-28. doi: 10.21614/chirurgia.114.1.18. PMID: 30830841
Laparoscopic paraaortic surgical staging in locally advanced cervical cancer: a single-center experience.
Vázquez-Vicente D, Fernández Del Bas B, García Villayzán J, Di Fiore HA, Luna Tirado J, Casado Echarren V, García-Foncillas J, Plaza Arranz J, Chiva L
Clin Transl Oncol 2018 Nov;20(11):1455-1459. Epub 2018 Apr 18 doi: 10.1007/s12094-018-1878-4. PMID: 29671223
Functional imaging to predict tumor response in locally advanced cervical cancer.
Barwick TD, Taylor A, Rockall A
Curr Oncol Rep 2013 Dec;15(6):549-58. doi: 10.1007/s11912-013-0344-2. PMID: 24114187

Therapy

Optimal cisplatin cycles in locally advanced cervical carcinoma patients treated with concurrent chemoradiotherapy.
Zeng Z, Wang W, Liu X, Wang G, Ren K, Zhang F, Hu K
Clin Transl Oncol 2023 Oct;25(10):2892-2900. Epub 2023 Apr 7 doi: 10.1007/s12094-023-03151-3. PMID: 37027060
Neoadjuvant chemotherapy in locally advanced cervical cancer in pregnancy-Review of the literature.
Mandic A, Maricic S, Malenkovic G, Stojic I, Gutic B
J BUON 2020 Mar-Apr;25(2):597-604. PMID: 32521840
Multimodality therapy for locally advanced cervical carcinoma: state of the art and future directions.
Monk BJ, Tewari KS, Koh WJ
J Clin Oncol 2007 Jul 10;25(20):2952-65. doi: 10.1200/JCO.2007.10.8324. PMID: 17617527
Combined chemotherapy and radiation therapy for cervical cancer.
Moore DH
J Natl Compr Canc Netw 2004 Nov;2(6):631-5. doi: 10.6004/jnccn.2004.0052. PMID: 19780305
Modern management of locally advanced cervical carcinoma.
Dueñas-Gonzalez A, Cetina L, Mariscal I, de la Garza J
Cancer Treat Rev 2003 Oct;29(5):389-99. doi: 10.1016/s0305-7372(03)00068-9. PMID: 12972357

Prognosis

Optimal cisplatin cycles in locally advanced cervical carcinoma patients treated with concurrent chemoradiotherapy.
Zeng Z, Wang W, Liu X, Wang G, Ren K, Zhang F, Hu K
Clin Transl Oncol 2023 Oct;25(10):2892-2900. Epub 2023 Apr 7 doi: 10.1007/s12094-023-03151-3. PMID: 37027060
Neoadjuvant chemotherapy does not improve the prognosis and lymph node metastasis rate of locally advanced cervical squamous cell carcinoma: A retrospective cohort study in China.
Yan W, Si L, Ding Y, Qiu S, Zhang Q, Liu L
Medicine (Baltimore) 2019 Sep;98(39):e17234. doi: 10.1097/MD.0000000000017234. PMID: 31574835Free PMC Article
Management of early and locally advanced cervical cancer.
Barbera L, Thomas G
Semin Oncol 2009 Apr;36(2):155-69. doi: 10.1053/j.seminoncol.2008.12.007. PMID: 19332250
Multimodality therapy for locally advanced cervical carcinoma: state of the art and future directions.
Monk BJ, Tewari KS, Koh WJ
J Clin Oncol 2007 Jul 10;25(20):2952-65. doi: 10.1200/JCO.2007.10.8324. PMID: 17617527
Modern management of locally advanced cervical carcinoma.
Dueñas-Gonzalez A, Cetina L, Mariscal I, de la Garza J
Cancer Treat Rev 2003 Oct;29(5):389-99. doi: 10.1016/s0305-7372(03)00068-9. PMID: 12972357

Clinical prediction guides

Optimal cisplatin cycles in locally advanced cervical carcinoma patients treated with concurrent chemoradiotherapy.
Zeng Z, Wang W, Liu X, Wang G, Ren K, Zhang F, Hu K
Clin Transl Oncol 2023 Oct;25(10):2892-2900. Epub 2023 Apr 7 doi: 10.1007/s12094-023-03151-3. PMID: 37027060
Locally advanced cervical carcinoma patients treated with chemoradiation followed by radical surgery: clinical response and oncological outcomes according to histotype after propensity score analysis.
Legge F, Bizzarri N, Gallotta V, Pedone Anchora L, Cosentino F, Turco LC, Certelli C, Macchia G, Valentini V, Scambia G, Ferrandina G
Eur J Surg Oncol 2022 Sep;48(9):2045-2052. Epub 2022 Apr 12 doi: 10.1016/j.ejso.2022.04.004. PMID: 35450757
Neoadjuvant Chemotherapy in Locally Advanced Cervical Carcinoma - a Role in Patients with Para-aortic Lymph Node Involvement? A 10-year Institutional Experience.
Green HM, Counsell N, Ward A, McCormack M
Clin Oncol (R Coll Radiol) 2022 Jul;34(7):e281-e290. Epub 2022 Jan 6 doi: 10.1016/j.clon.2021.12.005. PMID: 35000828
Laparoscopic paraaortic surgical staging in locally advanced cervical cancer: a single-center experience.
Vázquez-Vicente D, Fernández Del Bas B, García Villayzán J, Di Fiore HA, Luna Tirado J, Casado Echarren V, García-Foncillas J, Plaza Arranz J, Chiva L
Clin Transl Oncol 2018 Nov;20(11):1455-1459. Epub 2018 Apr 18 doi: 10.1007/s12094-018-1878-4. PMID: 29671223
Functional imaging to predict tumor response in locally advanced cervical cancer.
Barwick TD, Taylor A, Rockall A
Curr Oncol Rep 2013 Dec;15(6):549-58. doi: 10.1007/s11912-013-0344-2. PMID: 24114187

Recent systematic reviews

Efficacy and safety of endostar combined with chemoradiotherapy versus chemoradiotherapy alone in locally advanced cervical cancer: A PRISMA-compliant systematic review and meta-analysis.
Maimaitiming N, Ma X, Wei Y, Cao L, Gao Y, Zhang L
Medicine (Baltimore) 2022 Sep 9;101(36):e30170. doi: 10.1097/MD.0000000000030170. PMID: 36086700Free PMC Article
Combined use of hyperthermia and radiation therapy for treating locally advanced cervical carcinoma.
Lutgens L, van der Zee J, Pijls-Johannesma M, De Haas-Kock DF, Buijsen J, Mastrigt GA, Lammering G, De Ruysscher DK, Lambin P
Cochrane Database Syst Rev 2010 Jan 20;(1):CD006377. doi: 10.1002/14651858.CD006377.pub2. PMID: 20091593

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