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Locally Advanced Cervical Squamous Cell Carcinoma

MedGen UID:
1775970
•Concept ID:
C5420818
•
Neoplastic Process

Definition

Cervical squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Cervical Squamous Cell Carcinoma

Professional guidelines

PubMed

Clinical Significance of Serum SCC Levels Before Treatment for Locally Advanced Cervical Squamous Cell Carcinoma.
Yamaoka Y, Tamura S, Yamanoi K, Taki M, Murakami R, Yamaguchi K, Hamanishi J, Mandai M
Anticancer Res 2024 May;44(5):2009-2019. doi: 10.21873/anticanres.17004. PMID: 38677756
Comparison of treatment outcomes between squamous cell carcinoma and adenocarcinoma of cervix after definitive radiotherapy or concurrent chemoradiotherapy.
Hu K, Wang W, Liu X, Meng Q, Zhang F
Radiat Oncol 2018 Dec 17;13(1):249. doi: 10.1186/s13014-018-1197-5. PMID: 30558636Free PMC Article
Multimodal treatment including hysterectomy improves survival in patients with locally advanced cervical cancer: A population-based, propensity score-matched analysis.
Wu SG, Zhang WW, Sun JY, Li FY, He ZY, Zhou J
Int J Surg 2017 Dec;48:122-127. Epub 2017 Oct 12 doi: 10.1016/j.ijsu.2017.10.028. PMID: 29032160

Recent clinical studies

Etiology

Neoadjuvant chemotherapy does not improve the prognosis and lymph node metastasis rate of locally advanced cervical squamous cell carcinoma: A retrospective cohort study in China.
Yan W, Si L, Ding Y, Qiu S, Zhang Q, Liu L
Medicine (Baltimore) 2019 Sep;98(39):e17234. doi: 10.1097/MD.0000000000017234. PMID: 31574835Free PMC Article
Effectiveness of Image-guided Brachytherapy in Patients With Locally Advanced Cervical Squamous Cell Carcinoma Receiving Concurrent Chemoradiotherapy.
Chen SW, Liang JA, Hung YC, Yeh LS, Chang WC, Lin WC, Chang YY
Anticancer Res 2019 Jun;39(6):3015-3024. doi: 10.21873/anticanres.13434. PMID: 31177143
Long-term Outcomes of Carbon-ion Radiotherapy for Locally Advanced Squamous Cell Carcinoma of the Uterine Cervix.
Okonogi N, Wakatsuki M, Kato S, Shiba S, Kobayashi D, Kiyohara H, Karasawa K, Ohno T, Nakano T, Kamada T, Shozu M; WORKING GROUP OF GYNECOLOGICAL TUMORS
Anticancer Res 2018 Jan;38(1):457-463. doi: 10.21873/anticanres.12244. PMID: 29277809
The Prognosis and Risk Stratification Based on Pelvic Lymph Node Characteristics in Patients With Locally Advanced Cervical Squamous Cell Carcinoma Treated With Concurrent Chemoradiotherapy.
Li X, Wei LC, Zhang Y, Zhao LN, Li WW, Ping LJ, Dang YZ, Hu J, Shi M
Int J Gynecol Cancer 2016 Oct;26(8):1472-9. doi: 10.1097/IGC.0000000000000778. PMID: 27400321
HK2 is a radiation resistant and independent negative prognostic factor for patients with locally advanced cervical squamous cell carcinoma.
Huang X, Liu M, Sun H, Wang F, Xie X, Chen X, Su J, He Y, Dai Y, Wu H, Shen L
Int J Clin Exp Pathol 2015;8(4):4054-63. Epub 2015 Apr 1 PMID: 26097593Free PMC Article

Diagnosis

Clinical Significance of Serum SCC Levels Before Treatment for Locally Advanced Cervical Squamous Cell Carcinoma.
Yamaoka Y, Tamura S, Yamanoi K, Taki M, Murakami R, Yamaguchi K, Hamanishi J, Mandai M
Anticancer Res 2024 May;44(5):2009-2019. doi: 10.21873/anticanres.17004. PMID: 38677756
The Prognosis and Risk Stratification Based on Pelvic Lymph Node Characteristics in Patients With Locally Advanced Cervical Squamous Cell Carcinoma Treated With Concurrent Chemoradiotherapy.
Li X, Wei LC, Zhang Y, Zhao LN, Li WW, Ping LJ, Dang YZ, Hu J, Shi M
Int J Gynecol Cancer 2016 Oct;26(8):1472-9. doi: 10.1097/IGC.0000000000000778. PMID: 27400321
HK2 is a radiation resistant and independent negative prognostic factor for patients with locally advanced cervical squamous cell carcinoma.
Huang X, Liu M, Sun H, Wang F, Xie X, Chen X, Su J, He Y, Dai Y, Wu H, Shen L
Int J Clin Exp Pathol 2015;8(4):4054-63. Epub 2015 Apr 1 PMID: 26097593Free PMC Article
Aberrant expression of osteopontin and E-cadherin indicates radiation resistance and poor prognosis for patients with cervical carcinoma.
Huang X, Qian Y, Wu H, Xie X, Zhou Q, Wang Y, Kuang W, Shen L, Li K, Su J, Shen L, Chen X
J Histochem Cytochem 2015 Feb;63(2):88-98. Epub 2014 Nov 7 doi: 10.1369/0022155414561329. PMID: 25380749Free PMC Article
High Expression of SOX2 and OCT4 Indicates Radiation Resistance and an Independent Negative Prognosis in Cervical Squamous Cell Carcinoma.
Shen L, Huang X, Xie X, Su J, Yuan J, Chen X
J Histochem Cytochem 2014 Jul;62(7):499-509. Epub 2014 Apr 7 doi: 10.1369/0022155414532654. PMID: 24710660Free PMC Article

Therapy

Neoadjuvant chemotherapy does not improve the prognosis and lymph node metastasis rate of locally advanced cervical squamous cell carcinoma: A retrospective cohort study in China.
Yan W, Si L, Ding Y, Qiu S, Zhang Q, Liu L
Medicine (Baltimore) 2019 Sep;98(39):e17234. doi: 10.1097/MD.0000000000017234. PMID: 31574835Free PMC Article
Effectiveness of Image-guided Brachytherapy in Patients With Locally Advanced Cervical Squamous Cell Carcinoma Receiving Concurrent Chemoradiotherapy.
Chen SW, Liang JA, Hung YC, Yeh LS, Chang WC, Lin WC, Chang YY
Anticancer Res 2019 Jun;39(6):3015-3024. doi: 10.21873/anticanres.13434. PMID: 31177143
Long-term Outcomes of Carbon-ion Radiotherapy for Locally Advanced Squamous Cell Carcinoma of the Uterine Cervix.
Okonogi N, Wakatsuki M, Kato S, Shiba S, Kobayashi D, Kiyohara H, Karasawa K, Ohno T, Nakano T, Kamada T, Shozu M; WORKING GROUP OF GYNECOLOGICAL TUMORS
Anticancer Res 2018 Jan;38(1):457-463. doi: 10.21873/anticanres.12244. PMID: 29277809
HK2 is a radiation resistant and independent negative prognostic factor for patients with locally advanced cervical squamous cell carcinoma.
Huang X, Liu M, Sun H, Wang F, Xie X, Chen X, Su J, He Y, Dai Y, Wu H, Shen L
Int J Clin Exp Pathol 2015;8(4):4054-63. Epub 2015 Apr 1 PMID: 26097593Free PMC Article
Genetic alterations of PIK3CA and tumor response in patients with locally advanced cervical squamous cell carcinoma treated with cisplatin-based concurrent chemoradiotherapy.
Wang J, Chai YL, Wang T, Liu JH, Dai PG, Liu Z
Exp Mol Pathol 2015 Jun;98(3):407-10. Epub 2015 Mar 13 doi: 10.1016/j.yexmp.2015.03.014. PMID: 25773678

Prognosis

Clinical value of serum biomarkers, squamous cell carcinoma antigen and apolipoprotein C-II in follow-up of patients with locally advanced cervical squamous cell carcinoma treated with radiation: A multicenter prospective cohort study.
Harima Y, Ariga T, Kaneyasu Y, Ikushima H, Tokumaru S, Shimamoto S, Takahashi T, Ii N, Tsujino K, Saito AI, Ushijima H, Toita T, Ohno T
PLoS One 2021;16(11):e0259235. Epub 2021 Nov 2 doi: 10.1371/journal.pone.0259235. PMID: 34727105Free PMC Article
Neoadjuvant chemotherapy does not improve the prognosis and lymph node metastasis rate of locally advanced cervical squamous cell carcinoma: A retrospective cohort study in China.
Yan W, Si L, Ding Y, Qiu S, Zhang Q, Liu L
Medicine (Baltimore) 2019 Sep;98(39):e17234. doi: 10.1097/MD.0000000000017234. PMID: 31574835Free PMC Article
The Prognosis and Risk Stratification Based on Pelvic Lymph Node Characteristics in Patients With Locally Advanced Cervical Squamous Cell Carcinoma Treated With Concurrent Chemoradiotherapy.
Li X, Wei LC, Zhang Y, Zhao LN, Li WW, Ping LJ, Dang YZ, Hu J, Shi M
Int J Gynecol Cancer 2016 Oct;26(8):1472-9. doi: 10.1097/IGC.0000000000000778. PMID: 27400321
HK2 is a radiation resistant and independent negative prognostic factor for patients with locally advanced cervical squamous cell carcinoma.
Huang X, Liu M, Sun H, Wang F, Xie X, Chen X, Su J, He Y, Dai Y, Wu H, Shen L
Int J Clin Exp Pathol 2015;8(4):4054-63. Epub 2015 Apr 1 PMID: 26097593Free PMC Article
Genetic alterations of PIK3CA and tumor response in patients with locally advanced cervical squamous cell carcinoma treated with cisplatin-based concurrent chemoradiotherapy.
Wang J, Chai YL, Wang T, Liu JH, Dai PG, Liu Z
Exp Mol Pathol 2015 Jun;98(3):407-10. Epub 2015 Mar 13 doi: 10.1016/j.yexmp.2015.03.014. PMID: 25773678

Clinical prediction guides

Clinical Significance of Serum SCC Levels Before Treatment for Locally Advanced Cervical Squamous Cell Carcinoma.
Yamaoka Y, Tamura S, Yamanoi K, Taki M, Murakami R, Yamaguchi K, Hamanishi J, Mandai M
Anticancer Res 2024 May;44(5):2009-2019. doi: 10.21873/anticanres.17004. PMID: 38677756
Clinical value of serum biomarkers, squamous cell carcinoma antigen and apolipoprotein C-II in follow-up of patients with locally advanced cervical squamous cell carcinoma treated with radiation: A multicenter prospective cohort study.
Harima Y, Ariga T, Kaneyasu Y, Ikushima H, Tokumaru S, Shimamoto S, Takahashi T, Ii N, Tsujino K, Saito AI, Ushijima H, Toita T, Ohno T
PLoS One 2021;16(11):e0259235. Epub 2021 Nov 2 doi: 10.1371/journal.pone.0259235. PMID: 34727105Free PMC Article
Neoadjuvant chemotherapy does not improve the prognosis and lymph node metastasis rate of locally advanced cervical squamous cell carcinoma: A retrospective cohort study in China.
Yan W, Si L, Ding Y, Qiu S, Zhang Q, Liu L
Medicine (Baltimore) 2019 Sep;98(39):e17234. doi: 10.1097/MD.0000000000017234. PMID: 31574835Free PMC Article
Comparison of treatment outcomes between squamous cell carcinoma and adenocarcinoma of cervix after definitive radiotherapy or concurrent chemoradiotherapy.
Hu K, Wang W, Liu X, Meng Q, Zhang F
Radiat Oncol 2018 Dec 17;13(1):249. doi: 10.1186/s13014-018-1197-5. PMID: 30558636Free PMC Article
Prognostic Value of Neutrophil-Related Factors in Locally Advanced Cervical Squamous Cell Carcinoma Patients Treated with Cisplatin-Based Concurrent Chemoradiotherapy.
Wang YY, Bai ZL, He JL, Yang Y, Zhao R, Hai P, Zhe H
Dis Markers 2016;2016:3740794. Epub 2016 Mar 20 doi: 10.1155/2016/3740794. PMID: 27087737Free PMC Article

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