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Unresectable Sarcoma

MedGen UID:
1669987
•Concept ID:
C4724976
•
Neoplastic Process

Definition

A sarcoma which is not amenable to surgical resection. [from NCI]

Professional guidelines

PubMed

Current status of and future prospects for the treatment of unresectable or metastatic gastrointestinal stromal tumours.
Naito Y, Nishida T, Doi T
Gastric Cancer 2023 May;26(3):339-351. Epub 2023 Mar 13 doi: 10.1007/s10120-023-01381-6. PMID: 36913072Free PMC Article
Management of In-Transit Metastases.
Queiroz MM, Bertolli E, Belfort FA, Munhoz RR
Curr Oncol Rep 2022 May;24(5):573-583. Epub 2022 Feb 22 doi: 10.1007/s11912-022-01216-0. PMID: 35192119
A risk-based treatment strategy for non-rhabdomyosarcoma soft-tissue sarcomas in patients younger than 30 years (ARST0332): a Children's Oncology Group prospective study.
Spunt SL, Million L, Chi YY, Anderson J, Tian J, Hibbitts E, Coffin C, McCarville MB, Randall RL, Parham DM, Black JO, Kao SC, Hayes-Jordan A, Wolden S, Laurie F, Speights R, Kawashima E, Skapek SX, Meyer W, Pappo AS, Hawkins DS
Lancet Oncol 2020 Jan;21(1):145-161. Epub 2019 Nov 27 doi: 10.1016/S1470-2045(19)30672-2. PMID: 31786124Free PMC Article

Recent clinical studies

Etiology

Evaluation of the efficacy and safety of immunotherapy in sarcoma: a two-center study.
Liao Z, Teng J, Li T, Liu H, Li T, Zhang C, Xing R, Teng S, Yang Y, Zhao J, Xiao W, Zhang G, Li MJ, Yao W, Yang J
Front Immunol 2024;15:1292325. Epub 2024 Mar 22 doi: 10.3389/fimmu.2024.1292325. PMID: 38585276Free PMC Article
Efficacy of tyrosine kinase inhibitors in patients with advanced or metastatic sarcomas after prior chemotherapy: A meta-analysis.
Li W, Liu L, Liang Z, Lai H, Wu J, Zhang H, Fang C
Medicine (Baltimore) 2024 Mar 15;103(11):e37423. doi: 10.1097/MD.0000000000037423. PMID: 38489731Free PMC Article
High-dose ifosfamide as second- or third-line chemotherapy in refractory bone and soft tissue sarcoma patients.
Lee SH, Chang MH, Baek KK, Han B, Lim T, Lee J, Park JO
Oncology 2011;80(3-4):257-61. Epub 2011 Jul 6 doi: 10.1159/000328795. PMID: 21734417
An intergroup phase III randomized study of doxorubicin and dacarbazine with or without ifosfamide and mesna in advanced soft tissue and bone sarcomas.
Antman K, Crowley J, Balcerzak SP, Rivkin SE, Weiss GR, Elias A, Natale RB, Cooper RM, Barlogie B, Trump DL
J Clin Oncol 1993 Jul;11(7):1276-85. doi: 10.1200/JCO.1993.11.7.1276. PMID: 8315425
Conformal radiotherapy for unresectable retroperitoneal soft tissue sarcoma.
Greiner RH, Munkel G, Blattmann H, Coray A, Kann R, Pedroni E, Thum P
Int J Radiat Oncol Biol Phys 1992;22(2):333-41. doi: 10.1016/0360-3016(92)90051-i. PMID: 1740394

Diagnosis

Concomitant trimodality therapy of re-irradiation, chemotherapy and regional hyperthermia for a pretreated inoperable sarcoma recurrence.
LI M, Andrä C, Niyazi M, Issels RD, Abdel-Rahman S, Oskan F, Manapov F
Tumori 2015 Mar-Apr;101(2):e54-6. doi: 10.5301/tj.5000250. PMID: 25838253
Feasibility of ablation as an alternative to surgical metastasectomy in patients with unresectable sarcoma pulmonary metastases.
Ding JH, Chua TC, Glenn D, Morris DL
Interact Cardiovasc Thorac Surg 2009 Dec;9(6):1051-3. Epub 2009 Sep 18 doi: 10.1510/icvts.2009.218743. PMID: 19767303
Response to mesna, doxorubicin, ifosfamide, and dacarbazine in 108 patients with metastatic or unresectable sarcoma and no prior chemotherapy.
Elias A, Ryan L, Sulkes A, Collins J, Aisner J, Antman KH
J Clin Oncol 1989 Sep;7(9):1208-16. doi: 10.1200/JCO.1989.7.9.1208. PMID: 2504890

Therapy

Evaluation of the efficacy and safety of immunotherapy in sarcoma: a two-center study.
Liao Z, Teng J, Li T, Liu H, Li T, Zhang C, Xing R, Teng S, Yang Y, Zhao J, Xiao W, Zhang G, Li MJ, Yao W, Yang J
Front Immunol 2024;15:1292325. Epub 2024 Mar 22 doi: 10.3389/fimmu.2024.1292325. PMID: 38585276Free PMC Article
Undifferentiated and Unresectable Sarcoma With NTRK3-Fusion in a Pediatric Patient Treated With Larotrectinib and Proton Beam Radiotherapy.
Olsen MR, Denu RA, Lyon JB, Gulliver JM, Capitini CM, DeSantes KB
J Pediatr Hematol Oncol 2022 Apr 1;44(3):e770-e774. doi: 10.1097/MPH.0000000000002358. PMID: 34862354Free PMC Article
An intergroup phase III randomized study of doxorubicin and dacarbazine with or without ifosfamide and mesna in advanced soft tissue and bone sarcomas.
Antman K, Crowley J, Balcerzak SP, Rivkin SE, Weiss GR, Elias A, Natale RB, Cooper RM, Barlogie B, Trump DL
J Clin Oncol 1993 Jul;11(7):1276-85. doi: 10.1200/JCO.1993.11.7.1276. PMID: 8315425
Response to mesna, doxorubicin, ifosfamide, and dacarbazine in 108 patients with metastatic or unresectable sarcoma and no prior chemotherapy.
Elias A, Ryan L, Sulkes A, Collins J, Aisner J, Antman KH
J Clin Oncol 1989 Sep;7(9):1208-16. doi: 10.1200/JCO.1989.7.9.1208. PMID: 2504890
Response to ifosfamide and mesna: 124 previously treated patients with metastatic or unresectable sarcoma.
Antman KH, Ryan L, Elias A, Sherman D, Grier HE
J Clin Oncol 1989 Jan;7(1):126-31. doi: 10.1200/JCO.1989.7.1.126. PMID: 2491883

Prognosis

Evaluation of the efficacy and safety of immunotherapy in sarcoma: a two-center study.
Liao Z, Teng J, Li T, Liu H, Li T, Zhang C, Xing R, Teng S, Yang Y, Zhao J, Xiao W, Zhang G, Li MJ, Yao W, Yang J
Front Immunol 2024;15:1292325. Epub 2024 Mar 22 doi: 10.3389/fimmu.2024.1292325. PMID: 38585276Free PMC Article
High-dose ifosfamide as second- or third-line chemotherapy in refractory bone and soft tissue sarcoma patients.
Lee SH, Chang MH, Baek KK, Han B, Lim T, Lee J, Park JO
Oncology 2011;80(3-4):257-61. Epub 2011 Jul 6 doi: 10.1159/000328795. PMID: 21734417
Isolated perfusion of the kidney with tumor necrosis factor for localized renal-cell carcinoma.
Walther MM, Jennings SB, Choyke PL, Andrich M, Hurley K, Linehan WM, Rosenberg SA, Alexander RB
World J Urol 1996;14 Suppl 1:S2-7. doi: 10.1007/BF00182056. PMID: 8738402
Conformal radiotherapy for unresectable retroperitoneal soft tissue sarcoma.
Greiner RH, Munkel G, Blattmann H, Coray A, Kann R, Pedroni E, Thum P
Int J Radiat Oncol Biol Phys 1992;22(2):333-41. doi: 10.1016/0360-3016(92)90051-i. PMID: 1740394

Clinical prediction guides

Evaluation of the efficacy and safety of immunotherapy in sarcoma: a two-center study.
Liao Z, Teng J, Li T, Liu H, Li T, Zhang C, Xing R, Teng S, Yang Y, Zhao J, Xiao W, Zhang G, Li MJ, Yao W, Yang J
Front Immunol 2024;15:1292325. Epub 2024 Mar 22 doi: 10.3389/fimmu.2024.1292325. PMID: 38585276Free PMC Article
Efficacy of tyrosine kinase inhibitors in patients with advanced or metastatic sarcomas after prior chemotherapy: A meta-analysis.
Li W, Liu L, Liang Z, Lai H, Wu J, Zhang H, Fang C
Medicine (Baltimore) 2024 Mar 15;103(11):e37423. doi: 10.1097/MD.0000000000037423. PMID: 38489731Free PMC Article
An intergroup phase III randomized study of doxorubicin and dacarbazine with or without ifosfamide and mesna in advanced soft tissue and bone sarcomas.
Antman K, Crowley J, Balcerzak SP, Rivkin SE, Weiss GR, Elias A, Natale RB, Cooper RM, Barlogie B, Trump DL
J Clin Oncol 1993 Jul;11(7):1276-85. doi: 10.1200/JCO.1993.11.7.1276. PMID: 8315425
Response to mesna, doxorubicin, ifosfamide, and dacarbazine in 108 patients with metastatic or unresectable sarcoma and no prior chemotherapy.
Elias A, Ryan L, Sulkes A, Collins J, Aisner J, Antman KH
J Clin Oncol 1989 Sep;7(9):1208-16. doi: 10.1200/JCO.1989.7.9.1208. PMID: 2504890
Response to ifosfamide and mesna: 124 previously treated patients with metastatic or unresectable sarcoma.
Antman KH, Ryan L, Elias A, Sherman D, Grier HE
J Clin Oncol 1989 Jan;7(1):126-31. doi: 10.1200/JCO.1989.7.1.126. PMID: 2491883

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