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Increased proportion of naive CD4 T cells

MedGen UID:
1687096
•Concept ID:
C5139536
•
Finding
Synonyms: Elevated proportion of naive CD4 T cells; Increased proportion of CD4+CD45RA+ cells; Increased proportion of naive thymus-derived CD4-positive, alpha-beta T cells
 
HPO: HP:0410375

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased proportion of naive CD4 T cells

Professional guidelines

PubMed

Graves' disease as immune reconstitution disease in HIV-positive patients is associated with naive and primary thymic emigrant CD4(+) T-cell recovery.
Sheikh V, Dersimonian R, Richterman AG, Porter BO, Natarajan V, Burbelo PD, Rupert A, Santich BH, Kardava L, Mican JM, Moir S, Sereti I
AIDS 2014 Jan 2;28(1):31-9. doi: 10.1097/QAD.0000000000000006. PMID: 23939238

Recent clinical studies

Etiology

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Systemic inflammation and cortical neurochemistry in never-medicated first episode-psychosis individuals.
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Diagnosis

Identification of genes related to glucose metabolism and analysis of the immune characteristics in Alzheimer's disease.
Wang Y, Shen Z, Wu H, Yu Z, Wu X, Zhou L, Guo F
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PLoS Med 2023 Jun;20(6):e1004249. Epub 2023 Jun 29 doi: 10.1371/journal.pmed.1004249. PMID: 37384596Free PMC Article
Peripheral Blood T Cells of Patients with IPAH Have a Reduced Cytokine-Producing Capacity.
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Therapy

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SIRT3 Activator Honokiol Inhibits Th17 Cell Differentiation and Alleviates Colitis.
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Dynamic comparison of early immune reactions and immune cell reconstitution after umbilical cord blood transplantation and peripheral blood stem cell transplantation.
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Prognosis

Identification of genes related to glucose metabolism and analysis of the immune characteristics in Alzheimer's disease.
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Clinical prediction guides

Identification of genes related to glucose metabolism and analysis of the immune characteristics in Alzheimer's disease.
Wang Y, Shen Z, Wu H, Yu Z, Wu X, Zhou L, Guo F
Brain Res 2023 Nov 15;1819:148545. Epub 2023 Aug 22 doi: 10.1016/j.brainres.2023.148545. PMID: 37619853
T cell-intrinsic STING signaling promotes regulatory T cell induction and immunosuppression by upregulating FOXP3 transcription in cervical cancer.
Ni H, Zhang H, Li L, Huang H, Guo H, Zhang L, Li C, Xu JX, Nie CP, Li K, Zhang X, Xia X, Li J
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005151. PMID: 36126994Free PMC Article
Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE.
Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
Regulatory T and B cells in transient hypogammaglobulinemia of infancy.
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
Age-associated B cells indicate disease activity in rheumatoid arthritis.
Bao W, Xie M, Ye Y
Cell Immunol 2022 Jul;377:104533. Epub 2022 May 6 doi: 10.1016/j.cellimm.2022.104533. PMID: 35594728

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