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Abnormal proportion of naive CD4 T cells

MedGen UID:
1698894
•Concept ID:
C5139534
•
Finding
Synonyms: Abnormal proportion of CD4+CD45RA+ cells; Abnormal proportion of naive thymus-derived CD4-positive, alpha-beta T cells
 
HPO: HP:0410373

Definition

Any abnormality in the proportion of naive CD4 T cells relative to the total number of T cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal proportion of naive CD4 T cells

Professional guidelines

PubMed

Protein-losing Enteropathy as a Complication and/or Differential Diagnosis of Common Variable Immunodeficiency.
Sanges S, Germain N, Vignes S, Séguy D, Stabler S, Etienne N, Terriou L, Launay D, Hachulla É, Huglo D, Dubucquoi S, Labalette M, Lefèvre G
J Clin Immunol 2022 Oct;42(7):1461-1472. Epub 2022 Jun 23 doi: 10.1007/s10875-022-01299-1. PMID: 35737255
Long-lasting decrease of CD4+/CD45RA+ T cells in HCL patients after 2-chlorodeoxyadenosine (2-CdA) treatment.
Raspadori D, Rondelli D, Birtolo S, Lenoci M, Nardi G, Scalia G, Sestigiani C, Tozzi M, Marotta G, Lauria F
Leukemia 1999 Aug;13(8):1254-7. doi: 10.1038/sj.leu.2401476. PMID: 10450754

Recent clinical studies

Etiology

Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE.
Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
Abnormal Shift in B Memory Cell Profile Is Associated With the Expansion of Circulating T Follicular Helper Cells via ICOS Signaling During Acute HIV-1 Infection.
Lu X, Zhang X, Cheung AKL, Moog C, Xia H, Li Z, Wang R, Ji Y, Xia W, Liu Z, Yuan L, Wang X, Wu H, Zhang T, Su B
Front Immunol 2022;13:837921. Epub 2022 Feb 10 doi: 10.3389/fimmu.2022.837921. PMID: 35222430Free PMC Article
Accelerated Maturation, Exhaustion, and Senescence of T cells in 22q11.2 Deletion Syndrome.
Smetanova J, Milota T, Rataj M, Bloomfield M, Sediva A, Klocperk A
J Clin Immunol 2022 Feb;42(2):274-285. Epub 2021 Oct 29 doi: 10.1007/s10875-021-01154-9. PMID: 34716533
T-cell abnormalities in common variable immunodeficiency: the hidden defect.
Wong GK, Huissoon AP
J Clin Pathol 2016 Aug;69(8):672-6. Epub 2016 May 6 doi: 10.1136/jclinpath-2015-203351. PMID: 27153873Free PMC Article
Impaired Ca²⁺ regulation of CD4⁺CD25⁺ regulatory T cells from pediatric asthma.
Yamamoto Y, Negoro T, Hoshi A, Wakagi A, Shimizu S, Banham AH, Ishii M, Akiyama H, Kiuchi Y, Sunaga S, Tobe T, Roncador G, Itabashi K, Nakano Y
Int Arch Allergy Immunol 2011;156(2):148-58. Epub 2011 May 17 doi: 10.1159/000322845. PMID: 21576985

Diagnosis

Protein-losing Enteropathy as a Complication and/or Differential Diagnosis of Common Variable Immunodeficiency.
Sanges S, Germain N, Vignes S, Séguy D, Stabler S, Etienne N, Terriou L, Launay D, Hachulla É, Huglo D, Dubucquoi S, Labalette M, Lefèvre G
J Clin Immunol 2022 Oct;42(7):1461-1472. Epub 2022 Jun 23 doi: 10.1007/s10875-022-01299-1. PMID: 35737255
Immune memory limits human longevity: the role of memory СD4+ T cells in age-related immune abnormalities.
Seledtsov VI, von Delwig AA
Expert Rev Vaccines 2020 Mar;19(3):209-215. Epub 2020 Apr 6 doi: 10.1080/14760584.2020.1745638. PMID: 32191535
Expanded CD4(+) Effector/Memory T Cell Subset in APECED Produces Predominantly Interferon Gamma.
Heikkilä N, Laakso SM, Mannerström H, Kekäläinen E, Saavalainen P, Jarva H, Arstila TP
J Clin Immunol 2016 Aug;36(6):555-63. Epub 2016 Jun 4 doi: 10.1007/s10875-016-0302-5. PMID: 27262317
Selective deficiency of naïve CD4+ T-lymphocytes in a child with congenital lymphoedema.
Chiappini E, Galli L, Giudizi MG, Azzari C, Niccoli AA, Romagnani S, de Martino M
Eur J Pediatr 2003 Nov;162(11):752-4. Epub 2003 Aug 22 doi: 10.1007/s00431-003-1295-7. PMID: 12937974
Long-lasting decrease of CD4+/CD45RA+ T cells in HCL patients after 2-chlorodeoxyadenosine (2-CdA) treatment.
Raspadori D, Rondelli D, Birtolo S, Lenoci M, Nardi G, Scalia G, Sestigiani C, Tozzi M, Marotta G, Lauria F
Leukemia 1999 Aug;13(8):1254-7. doi: 10.1038/sj.leu.2401476. PMID: 10450754

Therapy

Abnormal Shift in B Memory Cell Profile Is Associated With the Expansion of Circulating T Follicular Helper Cells via ICOS Signaling During Acute HIV-1 Infection.
Lu X, Zhang X, Cheung AKL, Moog C, Xia H, Li Z, Wang R, Ji Y, Xia W, Liu Z, Yuan L, Wang X, Wu H, Zhang T, Su B
Front Immunol 2022;13:837921. Epub 2022 Feb 10 doi: 10.3389/fimmu.2022.837921. PMID: 35222430Free PMC Article
Efficacy of tocilizumab therapy in a patient with severe pancytopenia associated with a STAT3 gain-of-function mutation.
Wang W, Liu L, Hui X, Wang Y, Ying W, Zhou Q, Hou J, Yang M, Sun B, Sun J, Wang X
BMC Immunol 2021 Mar 17;22(1):19. doi: 10.1186/s12865-021-00411-1. PMID: 33731004Free PMC Article
Skewed T cell responses to Epstein-Barr virus in long-term asymptomatic kidney transplant recipients.
Nakid-Cordero C, Arzouk N, Gauthier N, Tarantino N, Larsen M, Choquet S, Burrel S, Autran B, Vieillard V, Guihot A
PLoS One 2019;14(10):e0224211. Epub 2019 Oct 22 doi: 10.1371/journal.pone.0224211. PMID: 31639143Free PMC Article
CD28-negative CD4+ and CD8+ T cells in antiretroviral therapy-naive HIV-infected adults enrolled in adult clinical trials group studies.
Tassiopoulos K, Landay A, Collier AC, Connick E, Deeks SG, Hunt P, Lewis DE, Wilson C, Bosch R
J Infect Dis 2012 Jun;205(11):1730-8. Epub 2012 Mar 23 doi: 10.1093/infdis/jis260. PMID: 22448010Free PMC Article
Long-lasting decrease of CD4+/CD45RA+ T cells in HCL patients after 2-chlorodeoxyadenosine (2-CdA) treatment.
Raspadori D, Rondelli D, Birtolo S, Lenoci M, Nardi G, Scalia G, Sestigiani C, Tozzi M, Marotta G, Lauria F
Leukemia 1999 Aug;13(8):1254-7. doi: 10.1038/sj.leu.2401476. PMID: 10450754

Prognosis

Establishing a human bone marrow single cell reference atlas to study ageing and diseases.
Lee NYS, Li M, Ang KS, Chen J
Front Immunol 2023;14:1127879. Epub 2023 Mar 15 doi: 10.3389/fimmu.2023.1127879. PMID: 37006302Free PMC Article
Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE.
Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
Regulatory T and B cells in transient hypogammaglobulinemia of infancy.
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
CD28-negative CD4+ and CD8+ T cells in antiretroviral therapy-naive HIV-infected adults enrolled in adult clinical trials group studies.
Tassiopoulos K, Landay A, Collier AC, Connick E, Deeks SG, Hunt P, Lewis DE, Wilson C, Bosch R
J Infect Dis 2012 Jun;205(11):1730-8. Epub 2012 Mar 23 doi: 10.1093/infdis/jis260. PMID: 22448010Free PMC Article
Selective deficiency of naïve CD4+ T-lymphocytes in a child with congenital lymphoedema.
Chiappini E, Galli L, Giudizi MG, Azzari C, Niccoli AA, Romagnani S, de Martino M
Eur J Pediatr 2003 Nov;162(11):752-4. Epub 2003 Aug 22 doi: 10.1007/s00431-003-1295-7. PMID: 12937974

Clinical prediction guides

Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE.
Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
Regulatory T and B cells in transient hypogammaglobulinemia of infancy.
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
CD4(+) T Cell Profile and Activation Response in Sickle Cell Disease Patients with Osteonecrosis.
Daltro PB, Ribeiro TO, Daltro GC, Meyer RJ, Fortuna V
Mediators Inflamm 2020;2020:1747894. Epub 2020 Oct 9 doi: 10.1155/2020/1747894. PMID: 33132753Free PMC Article
Impaired Ca²⁺ regulation of CD4⁺CD25⁺ regulatory T cells from pediatric asthma.
Yamamoto Y, Negoro T, Hoshi A, Wakagi A, Shimizu S, Banham AH, Ishii M, Akiyama H, Kiuchi Y, Sunaga S, Tobe T, Roncador G, Itabashi K, Nakano Y
Int Arch Allergy Immunol 2011;156(2):148-58. Epub 2011 May 17 doi: 10.1159/000322845. PMID: 21576985
Immunological abnormalities in the natural history of HIV infection: mechanisms and clinical relevance.
Miedema F
Immunodefic Rev 1992;3(3):173-93. PMID: 1354968

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