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Increased helper T cell proportion

MedGen UID:
1708381
•Concept ID:
C5398014
•
Finding
Synonyms: Elevated helper T cell proportion; Increased proportion T-helper cells
 
HPO: HP:0500264

Definition

Increased proportion of helper T cells relative to the total number of T cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased helper T cell proportion

Professional guidelines

PubMed

High-dimensional analysis of T-cell profiling variations following belimumab treatment in systemic lupus erythematosus.
Maeda S, Hashimoto H, Maeda T, Tamechika SY, Isogai S, Naniwa T, Niimi A
Lupus Sci Med 2023 Oct;10(2) doi: 10.1136/lupus-2023-000976. PMID: 37802602Free PMC Article
Immunogenicity risk assessment for biotherapeutics through in vitro detection of CD134 and CD137 on T helper cells.
Cohen S, Myneni S, Batt A, Guerrero J, Brumm J, Chung S
MAbs 2021 Jan-Dec;13(1):1898831. doi: 10.1080/19420862.2021.1898831. PMID: 33729092Free PMC Article
Definition of B cell helper T cells in rheumatoid arthritis and their behavior during treatment.
Lucas C, Perdriger A, Amé P
Semin Arthritis Rheum 2020 Oct;50(5):867-872. Epub 2020 Jul 13 doi: 10.1016/j.semarthrit.2020.06.021. PMID: 32896702

Recent clinical studies

Etiology

Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4(+) T Cells in COVID-19.
Meckiff BJ, Ramírez-Suástegui C, Fajardo V, Chee SJ, Kusnadi A, Simon H, Eschweiler S, Grifoni A, Pelosi E, Weiskopf D, Sette A, Ay F, Seumois G, Ottensmeier CH, Vijayanand P
Cell 2020 Nov 25;183(5):1340-1353.e16. Epub 2020 Oct 5 doi: 10.1016/j.cell.2020.10.001. PMID: 33096020Free PMC Article
T-cell defects and postpartum depression.
Osborne LM, Gilden J, Kamperman AM, Hoogendijk WJG, Spicer J, Drexhage HA, Bergink V
Brain Behav Immun 2020 Jul;87:397-403. Epub 2020 Jan 8 doi: 10.1016/j.bbi.2020.01.007. PMID: 31926288Free PMC Article
Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt(+) Regulatory T Cells and Exacerbate Colitis in Mice.
Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ
Immunity 2019 Jan 15;50(1):212-224.e4. doi: 10.1016/j.immuni.2018.12.015. PMID: 30650377Free PMC Article
Gestational Diabetes and T-cell (Th1/Th2/Th17/Treg) Immune Profile.
Sifnaios E, Mastorakos G, Psarra K, Panagopoulos ND, Panoulis K, Vitoratos N, Rizos D, Creatsas G
In Vivo 2019 Jan-Feb;33(1):31-40. doi: 10.21873/invivo.11435. PMID: 30587599Free PMC Article
T Follicular Regulatory Cells and Antibody Responses in Transplantation.
Wallin EF
Transplantation 2018 Oct;102(10):1614-1623. doi: 10.1097/TP.0000000000002224. PMID: 29757907Free PMC Article

Diagnosis

Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus.
Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Imbalance in B cell and T Follicular Helper Cell Subsets in Pulmonary Sarcoidosis.
Kudryavtsev I, Serebriakova M, Starshinova A, Zinchenko Y, Basantsova N, Malkova A, Soprun L, Churilov LP, Toubi E, Yablonskiy P, Shoenfeld Y
Sci Rep 2020 Jan 23;10(1):1059. doi: 10.1038/s41598-020-57741-0. PMID: 31974463Free PMC Article
Gestational Diabetes and T-cell (Th1/Th2/Th17/Treg) Immune Profile.
Sifnaios E, Mastorakos G, Psarra K, Panagopoulos ND, Panoulis K, Vitoratos N, Rizos D, Creatsas G
In Vivo 2019 Jan-Feb;33(1):31-40. doi: 10.21873/invivo.11435. PMID: 30587599Free PMC Article
T Follicular Regulatory Cells and Antibody Responses in Transplantation.
Wallin EF
Transplantation 2018 Oct;102(10):1614-1623. doi: 10.1097/TP.0000000000002224. PMID: 29757907Free PMC Article
Increased T-helper 17.1 cells in sarcoidosis mediastinal lymph nodes.
Broos CE, Koth LL, van Nimwegen M, In 't Veen JCCM, Paulissen SMJ, van Hamburg JP, Annema JT, Heller-Baan R, Kleinjan A, Hoogsteden HC, Wijsenbeek MS, Hendriks RW, van den Blink B, Kool M
Eur Respir J 2018 Mar;51(3) Epub 2018 Mar 1 doi: 10.1183/13993003.01124-2017. PMID: 29449421

Therapy

SIRT3 Activator Honokiol Inhibits Th17 Cell Differentiation and Alleviates Colitis.
Chen X, Zhang M, Zhou F, Gu Z, Li Y, Yu T, Peng C, Zhou L, Li X, Zhu D, Zhang X, Yu C
Inflamm Bowel Dis 2023 Dec 5;29(12):1929-1940. doi: 10.1093/ibd/izad099. PMID: 37335900Free PMC Article
Levels of Peripheral Th17 Cells and Th17-Related Cytokines in Patients with Ankylosing Spondylitis: A Meta-analysis.
Su QY, Zheng JW, Yang JY, Zhang TY, Song S, Zhao R, Di JK, Zhang SX, Wang CH, Gao HY
Adv Ther 2022 Oct;39(10):4423-4439. Epub 2022 Aug 12 doi: 10.1007/s12325-022-02240-z. PMID: 35960483
UHRF1 downregulation promotes T follicular helper cell differentiation by increasing BCL6 expression in SLE.
Liu L, Hu L, Yang L, Jia S, Du P, Min X, Wu J, Wu H, Long H, Lu Q, Zhao M
Clin Epigenetics 2021 Feb 10;13(1):31. doi: 10.1186/s13148-021-01007-7. PMID: 33568199Free PMC Article
T Follicular Regulatory Cells and Antibody Responses in Transplantation.
Wallin EF
Transplantation 2018 Oct;102(10):1614-1623. doi: 10.1097/TP.0000000000002224. PMID: 29757907Free PMC Article
Mechanism of action of allergen immunotherapy.
Şahin E, Bafaqeeh SA, Güven SG, Çetinkaya EA, Muluk NB, Coşkun ZO, Lopatin A, Kar M, Pinarbasli MO, Cingi C
Am J Rhinol Allergy 2016 Sep 1;30(5):1-3. doi: 10.2500/ajra.2016.30.4367. PMID: 27658024

Prognosis

Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus.
Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Definition of B cell helper T cells in rheumatoid arthritis and their behavior during treatment.
Lucas C, Perdriger A, Amé P
Semin Arthritis Rheum 2020 Oct;50(5):867-872. Epub 2020 Jul 13 doi: 10.1016/j.semarthrit.2020.06.021. PMID: 32896702
Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt(+) Regulatory T Cells and Exacerbate Colitis in Mice.
Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ
Immunity 2019 Jan 15;50(1):212-224.e4. doi: 10.1016/j.immuni.2018.12.015. PMID: 30650377Free PMC Article
Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice.
Wong SH, Zhao L, Zhang X, Nakatsu G, Han J, Xu W, Xiao X, Kwong TNY, Tsoi H, Wu WKK, Zeng B, Chan FKL, Sung JJY, Wei H, Yu J
Gastroenterology 2017 Dec;153(6):1621-1633.e6. Epub 2017 Aug 18 doi: 10.1053/j.gastro.2017.08.022. PMID: 28823860
The role of interleukin-17A in psoriatic disease.
Adami S, Cavani A, Rossi F, Girolomoni G
BioDrugs 2014 Dec;28(6):487-97. doi: 10.1007/s40259-014-0098-x. PMID: 24890029

Clinical prediction guides

Alteration in endometrial helper T-cell subgroups in chronic endometritis.
Kitazawa J, Kimura F, Nakamura A, Morimune A, Hanada T, Amano T, Tsuji S, Kasahara K, Satooka H, Hirata T, Kushima R, Murakami T
Am J Reprod Immunol 2021 Mar;85(3):e13372. Epub 2020 Nov 25 doi: 10.1111/aji.13372. PMID: 33155317
Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4(+) T Cells in COVID-19.
Meckiff BJ, Ramírez-Suástegui C, Fajardo V, Chee SJ, Kusnadi A, Simon H, Eschweiler S, Grifoni A, Pelosi E, Weiskopf D, Sette A, Ay F, Seumois G, Ottensmeier CH, Vijayanand P
Cell 2020 Nov 25;183(5):1340-1353.e16. Epub 2020 Oct 5 doi: 10.1016/j.cell.2020.10.001. PMID: 33096020Free PMC Article
Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt(+) Regulatory T Cells and Exacerbate Colitis in Mice.
Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ
Immunity 2019 Jan 15;50(1):212-224.e4. doi: 10.1016/j.immuni.2018.12.015. PMID: 30650377Free PMC Article
Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice.
Wong SH, Zhao L, Zhang X, Nakatsu G, Han J, Xu W, Xiao X, Kwong TNY, Tsoi H, Wu WKK, Zeng B, Chan FKL, Sung JJY, Wei H, Yu J
Gastroenterology 2017 Dec;153(6):1621-1633.e6. Epub 2017 Aug 18 doi: 10.1053/j.gastro.2017.08.022. PMID: 28823860
The regulation of the Treg/Th17 balance by mesenchymal stem cells in human systemic lupus erythematosus.
Wang D, Huang S, Yuan X, Liang J, Xu R, Yao G, Feng X, Sun L
Cell Mol Immunol 2017 May;14(5):423-431. Epub 2015 Oct 5 doi: 10.1038/cmi.2015.89. PMID: 26435067Free PMC Article

Recent systematic reviews

Increased expression of T helper 17 cells and interleukin-17 in atopic dermatitis: a systematic review and meta-analysis.
Mao Y, Yang C, Tang L, Liu G, Cheng L, Chen M
Ann Palliat Med 2021 Dec;10(12):12801-12809. doi: 10.21037/apm-21-3590. PMID: 35016438
Evidence for Local and Systemic Immune Activation in Functional Dyspepsia and the Irritable Bowel Syndrome: A Systematic Review.
Burns G, Carroll G, Mathe A, Horvat J, Foster P, Walker MM, Talley NJ, Keely S
Am J Gastroenterol 2019 Mar;114(3):429-436. doi: 10.1038/s41395-018-0377-0. PMID: 30839392

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