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Unresectable Salivary Gland Carcinoma

MedGen UID:
1777899
•Concept ID:
C5420538
•
Neoplastic Process

Definition

Salivary gland carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Salivary Gland Carcinoma

Professional guidelines

PubMed

Radiotherapy in the management of rare gastrointestinal cancers: A systematic review.
Bellefkih FZ, Benchakroun N, Lalya I, Amaoui B, El Kacemi H, Acharki A, El Hfid M, El Mazghi A, Chekrine T, Bouchbika Z, Jouhadi H, Sahraoui S, Tawfiq N, Michalet M
Cancer Radiother 2023 Sep;27(6-7):622-637. Epub 2023 Jul 25 doi: 10.1016/j.canrad.2023.06.010. PMID: 37500390
Management of Adenoid Cystic Carcinoma of the Head and Neck: Experience of the National Cancer Institute, Egypt.
Ayoub N, Nozhy A, Shawki A, Hassouna A, Ibraheem D, Elmahdy M, Amin A
Gulf J Oncolog 2022 May;1(39):63-69. PMID: 35695348
Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article

Recent clinical studies

Etiology

Targeting human EGFR 2 (HER2) in salivary gland carcinoma.
Wotman M, El-Naggar A, Ferrarotto R
Expert Rev Anticancer Ther 2023 Jun;23(6):573-582. Epub 2023 May 16 doi: 10.1080/14737140.2023.2208350. PMID: 37114470
Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article
Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma.
Ha H, Keam B, Ock CY, Kim TM, Kim JH, Chung EJ, Kwon SK, Ahn SH, Wu HG, Sung MW, Heo DS
Korean J Intern Med 2021 Jan;36(1):175-181. Epub 2020 Mar 30 doi: 10.3904/kjim.2019.104. PMID: 32218101Free PMC Article
Major and minor salivary gland tumours.
Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ
Crit Rev Oncol Hematol 2020 Aug;152:102959. Epub 2020 May 18 doi: 10.1016/j.critrevonc.2020.102959. PMID: 32485526
Minor salivary gland carcinoma: a review of 35 cases.
Haymerle G, Schneider S, Harris L, Häupl T, Schopper C, Pammer J, Grasl MCh, Erovic BM
Eur Arch Otorhinolaryngol 2016 Sep;273(9):2717-26. Epub 2015 Oct 23 doi: 10.1007/s00405-015-3805-4. PMID: 26498950

Diagnosis

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article
Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma.
Ha H, Keam B, Ock CY, Kim TM, Kim JH, Chung EJ, Kwon SK, Ahn SH, Wu HG, Sung MW, Heo DS
Korean J Intern Med 2021 Jan;36(1):175-181. Epub 2020 Mar 30 doi: 10.3904/kjim.2019.104. PMID: 32218101Free PMC Article
Adenoid Cystic Carcinoma.
Castelnuovo P, Turri-Zanoni M
Adv Otorhinolaryngol 2020;84:197-209. Epub 2020 Jul 30 doi: 10.1159/000457939. PMID: 32731238
Major and minor salivary gland tumours.
Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ
Crit Rev Oncol Hematol 2020 Aug;152:102959. Epub 2020 May 18 doi: 10.1016/j.critrevonc.2020.102959. PMID: 32485526
Tracheobronchial gland tumors.
Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566

Therapy

Targeting human EGFR 2 (HER2) in salivary gland carcinoma.
Wotman M, El-Naggar A, Ferrarotto R
Expert Rev Anticancer Ther 2023 Jun;23(6):573-582. Epub 2023 May 16 doi: 10.1080/14737140.2023.2208350. PMID: 37114470
Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma.
Ha H, Keam B, Ock CY, Kim TM, Kim JH, Chung EJ, Kwon SK, Ahn SH, Wu HG, Sung MW, Heo DS
Korean J Intern Med 2021 Jan;36(1):175-181. Epub 2020 Mar 30 doi: 10.3904/kjim.2019.104. PMID: 32218101Free PMC Article
Efficacy and toxicity of sorafenib in patients with adenoid cystic carcinoma of the head and neck: a case series of five patients.
Couvreur K, Celine J, Marlies B, Randal D, Philippe D, Frederic D, Sylvie R
Acta Clin Belg 2020 Oct;75(5):362-369. Epub 2019 Jun 23 doi: 10.1080/17843286.2019.1633490. PMID: 31232197
A rationale for chemoradiation (vs radiotherapy) in salivary gland cancers? On behalf of the REFCOR (French rare head and neck cancer network).
Cerda T, Sun XS, Vignot S, Marcy PY, Baujat B, Baglin AC, Ali AM, Testelin S, Reyt E, Janot F, Thariat J
Crit Rev Oncol Hematol 2014 Aug;91(2):142-58. Epub 2014 Feb 16 doi: 10.1016/j.critrevonc.2014.02.002. PMID: 24636481
Tracheobronchial gland tumors.
Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566

Prognosis

Targeting human EGFR 2 (HER2) in salivary gland carcinoma.
Wotman M, El-Naggar A, Ferrarotto R
Expert Rev Anticancer Ther 2023 Jun;23(6):573-582. Epub 2023 May 16 doi: 10.1080/14737140.2023.2208350. PMID: 37114470
Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article
Major and minor salivary gland tumours.
Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ
Crit Rev Oncol Hematol 2020 Aug;152:102959. Epub 2020 May 18 doi: 10.1016/j.critrevonc.2020.102959. PMID: 32485526
Minor salivary gland carcinoma: a review of 35 cases.
Haymerle G, Schneider S, Harris L, Häupl T, Schopper C, Pammer J, Grasl MCh, Erovic BM
Eur Arch Otorhinolaryngol 2016 Sep;273(9):2717-26. Epub 2015 Oct 23 doi: 10.1007/s00405-015-3805-4. PMID: 26498950
A rationale for chemoradiation (vs radiotherapy) in salivary gland cancers? On behalf of the REFCOR (French rare head and neck cancer network).
Cerda T, Sun XS, Vignot S, Marcy PY, Baujat B, Baglin AC, Ali AM, Testelin S, Reyt E, Janot F, Thariat J
Crit Rev Oncol Hematol 2014 Aug;91(2):142-58. Epub 2014 Feb 16 doi: 10.1016/j.critrevonc.2014.02.002. PMID: 24636481

Clinical prediction guides

Near-infrared photoimmunotherapy for salivary duct carcinoma.
Makino T, Sato Y, Uraguchi K, Naoi Y, Fukuda Y, Ando M
Auris Nasus Larynx 2024 Apr;51(2):323-327. Epub 2023 Sep 27 doi: 10.1016/j.anl.2023.09.006. PMID: 37775468
Targeting human EGFR 2 (HER2) in salivary gland carcinoma.
Wotman M, El-Naggar A, Ferrarotto R
Expert Rev Anticancer Ther 2023 Jun;23(6):573-582. Epub 2023 May 16 doi: 10.1080/14737140.2023.2208350. PMID: 37114470
Trophoblast Cell Surface Antigen 2 (Trop-2) Protein is Highly Expressed in Salivary Gland Carcinomas and Represents a Potential Therapeutic Target.
Wolber P, Nachtsheim L, Hoffmann F, Klußmann JP, Meyer M, von Eggeling F, Guntinas-Lichius O, Quaas A, Arolt C
Head Neck Pathol 2021 Dec;15(4):1147-1155. Epub 2021 Apr 22 doi: 10.1007/s12105-021-01325-5. PMID: 33886073Free PMC Article
Phosphorylated epidermal growth factor receptor expression and KRAS mutation status in salivary gland carcinomas.
Schneider T, Strehl A, Linz C, Brands R, Hartmann S, Beckford F, Rosenwald A, Kübler AC, Müller-Richter UD
Clin Oral Investig 2016 Apr;20(3):541-51. Epub 2015 Aug 6 doi: 10.1007/s00784-015-1541-1. PMID: 26245271
Salivary gland carcinoma treated with concomitant chemoradiation with intraarterial cisplatin and docetaxel.
Maruya S, Namba A, Matsubara A, Kakehata S, Takeda I, Shirasaki T, Hatayama Y, Nagahata M, Yokoyama J, Shinkawa H
Int J Clin Oncol 2006 Oct;11(5):403-6. doi: 10.1007/s10147-006-0587-0. PMID: 17058139

Recent systematic reviews

Radiotherapy in the management of rare gastrointestinal cancers: A systematic review.
Bellefkih FZ, Benchakroun N, Lalya I, Amaoui B, El Kacemi H, Acharki A, El Hfid M, El Mazghi A, Chekrine T, Bouchbika Z, Jouhadi H, Sahraoui S, Tawfiq N, Michalet M
Cancer Radiother 2023 Sep;27(6-7):622-637. Epub 2023 Jul 25 doi: 10.1016/j.canrad.2023.06.010. PMID: 37500390

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